4209-04-5

Basic information

• Product Name: 2-CHLORO-1-(4-IODOPHENYL)ETHANONE
• Synonyms: 2-Chloro-1-(4-iodophenyl)ethanone; ethanone, 2-chloro-1-(4-iodophenyl)-
• CAS NO: 4209-04-5
• Molecular Formula: C₈H₆ClIO
• Molecular Weight: 280.4901
• Mol File: 4209-04-5.mol

Chemical Properties

• Melting Point: 148-150 °C
• Boiling Point: 325.2°Cat760mmHg
• Flash Point: 150.5°C
• Appearance: /
• Density: 1.816g/cm³
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-CHLORO-1-(4-IODOPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1-(4-IODOPHENYL)ETHANONE(4209-04-5)
• EPA Substance Registry System: 2-CHLORO-1-(4-IODOPHENYL)ETHANONE(4209-04-5)

Safety Data

• Hazardous Substances Data: 4209-04-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6ClIO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

Upstream product

• 92527-07-6 1-(4-(dichloro-λ³-iodanyl)phenyl)ethan-1-one 
• 591-50-4 iodobenzene 
• 79-04-9 chloroacetyl chloride 
• 68120-56-9 1-(4-iodophenyl)ethanol 
• 52470-94-7 2-diazo-1-(4-iodophenyl)ethanone 

Downstream Products

• 66121-86-6 4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-benzenesulfonamide 
• 66122-16-5 4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-3-methyl-benzenesulfonamide 
• 66122-06-3 4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-2-methyl-benzenesulfonamide 
• 66121-96-8 2-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-5-methyl-benzenesulfonamide 
• 113813-55-1 [2-Chloro-1-hydroxy-1-(4-iodo-phenyl)-ethyl]-phosphonic acid diethyl ester 
• 13329-40-3 4-Iodoacetophenone 
• 113813-47-1 [2-Chloro-1-hydroxy-1-(4-iodo-phenyl)-ethyl]-phosphonic acid dimethyl ester 
• 113813-44-8 Phosphoric acid 1-(4-iodo-phenyl)-vinyl ester dimethyl ester 
• 18276-79-4 diethyl (1-(4-iodophenyl)vinyl)phosphate 
• 619-58-9 4-iodobenzoic acid 
• 90842-69-6 (2-(4-iodophenyl)-2-oxoethyl) acetate 
• 832096-07-8 2,2-dichloro-1-(4-iodophenyl)ethan-1-one 

Relevant articles and documents

Facile and efficient preparation of α-halomethyl ketones from α-diazo ketones catalyzed by iron(III) halides and silica gel

An efficient and mild method for the synthesis of α-halomethyl ketones from α-diazo ketones was developed using ferric chloride or bromide as the halogen source and silica gel as the hydrogen source, with good to excellent yields.

Direct conversion of alcohols to α-chloro aldehydes and α-chloro ketones

Direct conversion of primary and secondary alcohols into the corresponding α-chloro aldehydes and α-chloro ketones using trichloroisocyanuric acid, serving both as stoichiometric oxidant and α-halogenating reagent, is reported. For primary alcohols, TEMPO has to be added as an oxidation catalyst, and for the transformation of secondary alcohols (TEMPO-free protocol), MeOH as an additive is essential to promote chlorination of the intermediary ketones.

Chemoenzymatic synthesis of enantiomerically pure terminal 1,2-diols

A new practical method for the enzymatic synthesis of 1,2-diols has been developed by employing a lipase catalyzed one-pot transesterification protocol. A series of substituted α-acetoxyphenylethanones 3a-g have been reduced to the corresponding alcohols under mild conditions employing sodium borohydride and moist neutral alumina, and further subjected for lipase catalyzed irreversible transesterification in the same pot to give mono- and diacetate diols (R)-4 and (S)-5, which on hydrolysis afforded terminal 1,2-diols, (R)- and (S)-6 in high enantiomeric excess.