4282-40-0

Basic information

• Product Name: 1-Iodoheptane
• Synonyms: I-Iodoheptane;1-Iodoheptane99%;1-Iodoheptane,98%;1-Jodheptan;1-Iodoheptane (stabilized with Copper chip);1-Iodoheptane, 98%, stab. with copper;Iodoheptane;1-Iodohptane
• CAS NO: 4282-40-0
• Molecular Formula: C₇H₁₅I
• Molecular Weight: 226.1
• EINECS: 224-285-8
• Product Categories: Iodine Compounds
• Mol File: 4282-40-0.mol
• Article Data: 23

Chemical Properties

• Melting Point: −48 °C(lit.)
• Boiling Point: 204 °C(lit.)
• Flash Point: 174 °F
• Appearance: clear colorless to pale yellow-orange liquid
• Density: 1.379 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.386mmHg at 25°C
• Refractive Index: n20/D 1.490(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: benzene: miscible(lit.)
• Water Solubility: immiscible
• Sensitive: Light Sensitive
• BRN: 1697161
• CAS DataBase Reference: 1-Iodoheptane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Iodoheptane(4282-40-0)
• EPA Substance Registry System: 1-Iodoheptane(4282-40-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• RTECS: MJ1050000
• F: 8
• TSCA: Yes
• Hazardous Substances Data: 4282-40-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to pale yellow-orange liquid. It is insoluble in water but soluble in ethanol, ether, acetone and chloroform. Exposure to light or long-term discoloration.

Uses

1-Iodoheptane is used in the functionalization of symmetrical star-shaped molecules with carborane clusters.

Synthesis

The Synthesis of 1-iodoheptane is as follows:Firstly, catechol reacts with phosphorus trichloride to produce o-phenylene phosphorous acid chloride, and then the produced compound reacts with heptanol to obtain colorless oily phosphite. Second, take 50.9g (0.20mol) of the above phosphite and 50.8g (0.20mol) of iodine into 500ml of dichloromethane. After that, stir at room temperature for 1h. Finally, use 10% sodium thiosulfate solution to wash away the unreacted iodine that may exist, then wash with 5% NaOH solution, 5% NaHCO3 solution, and saturated NaCl solution in turn, separate the organic phase, evaporate the solvent, and depressurize Distill and collect fractions at 96-104°C (5.33-6.4kPa) to obtain 39g 1-Iodoheptane with a yield of 86%.

InChI:InChI=1/C7H15I/c1-2-3-4-5-6-7-8/h2-7H2,1H3

Upstream product

• 629-06-1 1-Chloroheptane 
• 111-71-7 heptanal 
• 111-70-6 n-heptan1ol 
• 1058649-58-3 ethoxymethyl heptyl ether 
• 71739-40-7 methoxymethyl heptyl ether 
• 111-14-8 oenanthic acid 
• 54573-13-6 1-iodo-hept-1-yne 
• 628-71-7 1-Heptyne 
• 1639-09-4 heptanethiol 
• 142-82-5 n-heptane 
• 661-11-0 1-fluoroheptane 
• 629-04-9 1-Bromoheptane 
• 16133-35-0 2-heptyloxy-benzo[1,3,2]dioxaphosphole 
• 74-85-1 ethene 

Downstream Products

• 57792-41-3 heptyl-p-tolyl ether 
• 102175-69-9 ethyl-heptyl-(1-methyl-2-phenyl-ethyl)-amine 
• 124-12-9 caprylnitrile 
• 98330-03-1 heptyl-(2-nitro-phenyl)-ether 
• 876498-09-8 2-heptyl-1-phenylbutane-1,3-dione 
• 15326-96-2 diethyl 2-benzyl-2-heptylmalonate 
• 111-71-7 heptanal 
• 693-39-0 1-nitroheptane 
• 629-43-6 1-heptyl nitrite 
• 19780-10-0 dodecan-5-one 
• 22026-12-6 6-tridecanone 
• 14476-38-1 heptadecan-8-one 
• 142-82-5 n-heptane 
• 1969-43-3 1-ethoxy-heptane 

Relevant articles and documents

Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides

Herein, we disclose a Ni-catalyzed formal aminocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, which proceeds via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent β-hydride elimination, and hydrolysis process. The reaction features wide functional group tolerance under mild conditions. Additionally, the selective, one-pot hydrolysis of reaction mixture under acid conditions allows for expedient synthesis of the corresponding alkyl carboxylic acid.

Homogeneous catalysis, heterogeneous recycling: A new family of branched molecules with hydrocarbon or fluorocarbon chains for the Friedl?nder synthesis of quinoline under solvent-free conditions

A new family of branched catalysts with hydrocarbon or fluorocarbon chains was used to catalyze Friedl?nder reaction between 2-aminoarylketones and α-methylene ketones under solvent-free conditions in good to excellent yields. The catalysts exhibit temperature-dependent solubility and such a thermomorphic character allows them to be recovered by filtration conveniently at room temperature and reused at least five times. To some extent, the branched catalysts with hydrocarbon chains are superior to those with fluorocarbon chains, as they are cheaper and more biodegradable.

Impact of fluorine substituents on the rates of nucleophilic aliphatic substitution and β-elimination

A measure of the quantitative effect of proximate fluorine substituents on the rates of SN2 and E2 reactions has been obtained through a study mainly of reactions of fluorinated n-alkyl bromides with weak base, strong nucleophile azide ion and strong base/nucleophile methoxide ion in the protic solvent methanol and the aprotic solvent, DMSO. The order of reactivity for SN2 reactions of azide in methanol at 50 °C was found to be: n-alkyl-Br > n-alkyl-CHFBr > n-perfluoroalkyl-CH2CH 2Br n-perfluoroalkyl-CH2Br > n-alkyl-CF2Br. Approximate relative rates of reaction were: 1, 0.20, 0.12, 1 × 10 -4, -5. The order of reactivity for E2 reactions was found to be: n-perfluoroalkyl-CH2CH2Br n-alkyl-CF2Br > n-alkyl-CHFBr > n-alkyl-Br. The approximate relative rates for reaction of methoxide in methanol at 50 °C were: 1100, 4.4, 1.9, 1.