443-81-2

Basic information

• Product Name: 2-Bromo-3-fluorophenol
• Synonyms: 2-BROMO-3-FLUOROPHENOL;3-Fluoro-2-bromophenol;Bromo-3-fluorophenol
• CAS NO: 443-81-2
• Molecular Formula: C₆H₄BrFO
• Molecular Weight: 191
• Product Categories: Aromatic Phenols;pharmacetical;Phenol&Thiophenol&Mercaptan;Aromatics, Miscellaneous Reagents
• Mol File: 443-81-2.mol

Chemical Properties

• Boiling Point: 196.141 °C at 760 mmHg
• Flash Point: 72.424 °C
• Appearance: light yellow liquid
• Density: 1.764 g/cm³
• Vapor Pressure: 0.288mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.43±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-fluorophenol(443-81-2)
• EPA Substance Registry System: 2-Bromo-3-fluorophenol(443-81-2)

Safety Data

• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 443-81-2(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

Uses

2-Bromo-3-fluorophenol has been used as a reactant in the preparation of diaryl ethers.

InChI:InChI=1/C6H4BrFO/c7-6-4(8)2-1-3-5(6)9/h1-3,9H

Upstream product

• 372-20-3 3-fluorophenol 
• 7664-93-9 sulfuric acid 
• 64248-56-2 1-bromo-2,6-difluorobenzene 
• 126940-10-1 1-fluoro-3-(methoxy-methoxy)benzene 
• 446-59-3 2‐bromo‐1‐fluoro‐3‐methoxybenzene 
• 863870-75-1 O-2-bromo-3-fluorophenyl N,N-diethylcarbamate 
• 205187-05-9 3-fluorophenyl N,N-diethyl-O-carbamate 

Downstream Products

• 7657-28-5 3-bromo-2-fluoro-4-hydroxy-benzaldehyde 
• 856076-73-8 3-bromo-4-fluoro-2-hydroxy-benzaldehyde 
• 861885-67-8 C₁₉H₁₂Br₂FNO₅ 
• 286836-06-4 2-(2-bromo-3-fluorophenoxy)-acetaldehyde diethyl acetal 
• 128868-60-0 4-bromo-1-benzofuran 
• 324769-12-2 O-(3-fluoro-2-bromophenyl)-N,N-diethylthiocarbamate 
• 773853-99-9 4-(2-fluoro-6-hydroxy-phenyl)-1,2,3,6-tetrahydro-pyridine-1-carboxylic acid tert-butyl ester 
• 1372147-54-0 4-[3-(benzyloxy)-2-bromophenoxymethyl]pyridine 
• 1372147-62-0 1-benzyl-4-[3-(benzyloxy)-2-bromophenoxymethyl]pyridinium bromide 
• 1372147-66-4 1-benzyl-4-[3-(benzyloxy)-2-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine 
• 1372147-75-5 benzyl 4-[3-(benzyloxy)-2-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine-1-carboxylate 
• 1206776-16-0 1-(benzyloxy)-2-bromo-3-fluorobenzene 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Preparation of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate

An efficient synthesis of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate in moderate to excellent yields is described. High regioselectivity was observed in some cases. Georg Thieme Verlag Stuttgart.

An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions

1-Butyl-3-methylpyridinium tribromide, [BMPy]Br3 proves to be a highly efficient, regioselective reagent/solvent for nuclear bromination of various anilines and phenols. The synthesis and characterization of the room temperature ionic liquid [BMPy]Br3 (2) is described. The bromination was carried out in the absence of organic solvents and in most cases the only extraction solvent needed was water. The spent 1-butyl-3-methylpyridinium bromide (1) was easily recycled.

A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols

Tandem Sonogashira coupling/5-endo-dig cyclization reactions on 2,3-dihalophenols suppose a straightforward entry to 4-halobenzo[b]furans, which can be easily transformed into 4-functionalized benzo[b]furans, that are difficult to synthesize by other proc

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