4471-41-4

Basic information

• Product Name: 1,4-bis[(2-hydroxyethyl)amino]anthraquinone
• Synonyms: 1,4-bis[(2-hydroxyethyl)amino]anthraquinone;1,4-bis(2-hydroxyethylamino)anthracene-9,10-dione;1,4-Bis[(2-hydroxyethyl)amino]-9,10-anthracenedione;1,4-Bis[(2-hydroxyethyl)amino]-9,10-anthraquinone;C.I.61545;C.I.Disperse Blue 23;1,4-Bis[(2-hydroxyethyl)amino]anthra-9,10-quinone;Acetoquinone Blue BF
• CAS NO: 4471-41-4
• Molecular Formula: C₁₈H₁₈N₂O₄
• Molecular Weight: 326.34652
• EINECS: 224-743-7
• Mol File: 4471-41-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 248°C
• Boiling Point: 464.4°C (rough estimate)
• Flash Point: 350.4°C
• Appearance: /
• Density: 1.2825 (rough estimate)
• Vapor Pressure: 4.28E-18mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• Water Solubility: 783.3ug/L(25 oC)
• CAS DataBase Reference: 1,4-bis[(2-hydroxyethyl)amino]anthraquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis[(2-hydroxyethyl)amino]anthraquinone(4471-41-4)
• EPA Substance Registry System: 1,4-bis[(2-hydroxyethyl)amino]anthraquinone(4471-41-4)

Safety Data

• Hazardous Substances Data: 4471-41-4(Hazardous Substances Data)

Usage

Preparation

1,4-Dihydroxyanthracene-9,10-dione or anthracene-1,4,9,10-tetraol?and 2-Aminoethanol condensation.

Properties and Applications

bright blue. For the strong sulfuric acid in purplish red, for purple diluted. Standard(Polyamide) Ironing Fastness Light Fastness Persperation Fastness Washing Fastness Fading Stain Fading Stain Fading Stain ISO 4-5 4-5 5 4-5 3 4-5 4-5

Standard(Polyamide)

Ironing Fastness

Fading

Stain

ISO

4-5

InChI:InChI=1/C18H18N2O4/c21-9-7-19-13-5-6-14(20-8-10-22)16-15(13)17(23)11-3-1-2-4-12(11)18(16)24/h1-6,19-22H,7-10H2

Upstream product

• 81-64-1 1,4-dihydroxy-9,10-anthracenedione 
• 141-43-5 ethanolamine 
• 17648-03-2 9,10-Dihydroxy-2,3-dihydro-anthracene-1,4-dione 
• 128-95-0 1,4-diamino-9,10-anthraquinone 
• 5327-72-0 1,4-diamino-anthracene-9,10-diol 
• 28736-42-7 1,4-difluoroanthracene-9,10-dione 
• 40498-13-3 2,3-dihydro-1,4-dihydroxyanthraquinone 
• 27343-67-5 1,4-bis-<2-Hydroxy-aethylamino>-anthrahydrochinon 
• 111271-34-2 N,N'-(9,10-dioxo-9,10-dihydro-anthracene-1,4-diyl)-bis-carbamic acid bis-(2-chloro-ethyl ester) 
• 75-21-8 oxirane 
• 64-19-7 acetic acid 
• 98-95-3 nitrobenzene 

Downstream Products

• 70477-04-2 1,4-bis<<2-(diethylamino)ethyl>amino>anthracene-9,10-dione 
• 64862-96-0 ametantrone 
• 3008-82-0 1,4-bis-(2-morpholin-4-yl-ethylamino)-anthraquinone 

Relevant articles and documents

Dyestuff, ink and electric wetting display device

The invention provides an organic dyestuff, ink and an electric wetting display device. Being different from extremely low solubility of a common dyestuff with a diamino substituted anthraquinone structure in a non-polar organic solvent, the dyestuff provided by the invention has very high solubility in the non-polar organic solvent, so that the dyestuff can be put into large-scale production. After the organic dyestuff is dissolved into the organic solvent, the ink applicable to electric wetting display, and the electric wetting display device applying the ink can be prepared.

Synthesis and Antitumor Evaluations of Symmetrically and Unsymmetrically Substituted 1,4-Bisanthracene-9,10-diones and 1,4-Bis-5,8-dihydroxyanthracene-9,10-diones

The ipso bis displacements of fluoride from 1,4-difluoroanthracene-9,10-dione (3) and 1,4-difluoro-5,8-dihydroxyanthracene-9,10-dione (4) by excess of a diamine (or a monoamine) in pyridine at room temperature lead to the symmetrically substituted 1,4-bis-substituted analogues 5 and 6, respectively.The ipso monodisplacements of fluoride from 3 and 4 can be accomplished by treatment with less than 1 molar equiv of a diamine (or a monoamine) to yield 7 and 8, respectively.Treatment of 7 or 8 with a different diamine leads to the unsymmetrically substituted1,4-bisanthracene-9,10-diones 9 and 10, respectively.Many of the synthetic unsymmetrical analogues have been evaluated for their antitumor activity against L1210 in vitro and in vivo.Cross resistance of analogue 10a with mitoxantrone (2) and doxorubicin was evaluated against MDR lines in vitro against human colon carcinoma LOVO and its subline resistant to DOXO (LOVO/DOXO).Potential mechanisms for the observed cytotoxicity are presented and discussed.