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450366-22-0

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450366-22-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 450366-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,0,3,6 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 450366-22:
(8*4)+(7*5)+(6*0)+(5*3)+(4*6)+(3*6)+(2*2)+(1*2)=130
130 % 10 = 0
So 450366-22-0 is a valid CAS Registry Number.

450366-22-0Relevant articles and documents

Development of a diketopiperazine-forming dipeptidyl Gly-Pro spacer for preparation of an antibody-drug conjugate

Manabe, Shino,Machida, Hikaru,Aihara, Yoshiyuki,Yasunaga, Masahiro,Ito, Yukishige,Matsumura, Yasuhiro

, p. 792 - 796 (2013)

We developed a novel diketopiperazine-forming dipeptidyl spacer aimed at application in antibody-drug conjugates. Enzymatic cleavage of a peptide linked to the Gly-Pro spacer resulted in formation of diketopiperazine, which was stable and non-toxic, and release of the parent drug. The Royal Society of Chemistry 2013.

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