450366-22-0Relevant articles and documents
Development of a diketopiperazine-forming dipeptidyl Gly-Pro spacer for preparation of an antibody-drug conjugate
Manabe, Shino,Machida, Hikaru,Aihara, Yoshiyuki,Yasunaga, Masahiro,Ito, Yukishige,Matsumura, Yasuhiro
, p. 792 - 796 (2013)
We developed a novel diketopiperazine-forming dipeptidyl spacer aimed at application in antibody-drug conjugates. Enzymatic cleavage of a peptide linked to the Gly-Pro spacer resulted in formation of diketopiperazine, which was stable and non-toxic, and release of the parent drug. The Royal Society of Chemistry 2013.