4701-17-1

Basic information

• Product Name: 5-Bromothiophene-2-carbaldehyde
• Synonyms: 2-Thiophenecarboxaldehyde, 5-bromo-;LABOTEST-BB LT00112291;5-BROMO-2-THIOPHENECARBALDEHYDE;5-BROMO-2-THIOPHENECARBOXALDEHYDE;5-BROMO-2-FORMYLTHIOPHENE;5-BROMOTHIOPHENE-2-ALDEHYDE;5-BROMO-THIOPHENE-2-CARBALDEHYDE;5-BROMOTHIOPHENE-2-CARBOXALDEHYDE
• CAS NO: 4701-17-1
• Molecular Formula: C5H3BrOS
• Molecular Weight: 191.05
• EINECS: 225-176-8
• Product Categories: Azoles;blocks;Bromides;Heterocycles;Aldehydes;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes;Heterocycle-oher series;alkyl bromide
• Mol File: 4701-17-1.mol

Chemical Properties

• Melting Point: 55°C
• Boiling Point: 105-107 °C11 mm Hg(lit.)
• Flash Point: 210 °F
• Appearance: Clear yellow to brown/Liquid After Melting
• Density: 1.607 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.065mmHg at 25°C
• Refractive Index: n20/D 1.637(lit.)
• Storage Temp.: 0-6°C
• Solubility: Soluble in chloroform and methanol.
• Sensitive: Air Sensitive
• BRN: 108404
• CAS DataBase Reference: 5-Bromothiophene-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromothiophene-2-carbaldehyde(4701-17-1)
• EPA Substance Registry System: 5-Bromothiophene-2-carbaldehyde(4701-17-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22-36
• WGK Germany: 3
• TSCA: N
• Hazardous Substances Data: 4701-17-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromothiophene-2-carbaldehyde is used as an intermediate compound for the synthesis of various pharmaceuticals, particularly those with anti-inflammatory and anti-tumor properties. Its ability to be incorporated into the structure of these drugs makes it a valuable component in the development of new medications.
Used in Radiochemistry:
5-Bromothiophene-2-carbaldehyde is used as a precursor for the preparation of 5-[18F]fluoro-2-thiophenecarboxaldehyde, a radiolabeled compound used in positron emission tomography (PET) imaging. This application allows for the visualization and tracking of biological processes in living organisms, contributing to the advancement of medical diagnostics.
Used in Biological Studies:
In the field of biological research, 5-Bromothiophene-2-carbaldehyde is utilized to study the anti-inflammatory and anti-tumor activities of the marine mangrove Rhizophora apiculata. Its presence in this context aids in understanding the therapeutic potential of natural compounds derived from the mangrove plant.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1422, 1950 DOI: 10.1021/ja01159a527

InChI:InChI=1/C5H3BrOS/c6-5-2-1-4(3-7)8-5/h1-3H

Upstream product

• 1003-09-4 2-bromothiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 98-03-3 thiophene-2-carbaldehyde 
• 3141-27-3 2,5-dibromothiophen 
• 109-94-4 formic acid ethyl ester 
• 7311-46-8 2-bromo-5-(chloromethyl)thiophene 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 636-72-6 2-thiophenemethanol 
• 765-50-4 2-Chloromethylthiophene 
• 5751-83-7 ethyl 5-bromothiophene-2-carboxylate 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 1448723-46-3 C₁₂H₁₁BrN₂O₃S₂ 

Downstream Products

• 81020-72-6 3c-(5-bromo-[2]thienyl)-2-p-tolyl-acrylonitrile 
• 28783-33-7 (E)-2-bromo-5-(2-nitrovinyl)thiophene 
• 96463-58-0 2-(4-bromo-phenyl)-3c-(5-bromo-[2]thienyl)-acrylonitrile 
• 81020-73-7 3c-(5-bromo-[2]thienyl)-2-phenyl-acrylonitrile 
• 81020-75-9 3c-(5-bromo-[2]thienyl)-2-(4-nitro-phenyl)-acrylonitrile 
• 40104-33-4 1-((5-bromothiophen-2-yl)methylene)thiosemicarbazide 
• 111796-20-4 (5-bromo-[2]thienyl)-bis-(4-dimethylamino-phenyl)-methane 
• 81020-71-5 3c-(5-bromo-[2]thienyl)-2-(4-methoxy-phenyl)-acrylonitrile 
• 39677-97-9 5-bromothiophene-2-carboxaldehyde phenylhydrazone 
• 81020-74-8 3c-(5-bromo-[2]thienyl)-2-(4-chloro-phenyl)-acrylonitrile 
• 73673-61-7 N-(5-bromo-thiophen-2-ylmethylene)-4-[5-(5-bromo-thiophen-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-aniline 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 75745-06-1 (5-bromo-2-thienylidene)-2-aminopyridine 
• 89035-33-6 4-[1-(5-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-2-phenyl-4H-oxazol-5-one 

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