4749-70-6

Basic information

• Product Name: methyl ethyl fumaric acid ester
• Synonyms: methyl ethyl fumaric acid ester
• CAS NO: 4749-70-6
• Molecular Weight: 158.154
• Mol File: 4749-70-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl ethyl fumaric acid ester(CAS DataBase Reference)
• NIST Chemistry Reference: methyl ethyl fumaric acid ester(4749-70-6)
• EPA Substance Registry System: methyl ethyl fumaric acid ester(4749-70-6)

Safety Data

• Hazardous Substances Data: 4749-70-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 2459-05-4 malonic acid monoethyl ester 
• 538-75-0 dicyclohexyl-carbodiimide 
• 623-73-4 diazoacetic acid ethyl ester 
• 111-66-0 oct-1-ene 
• 592-41-6 1-hexene 
• 6832-16-2 methyl diazoacetate 

Downstream Products

• 1277179-79-9 (2R,3S)-2-ethyl 3-methyl 1-((R)-1-phenylethyl)aziridine-2,3-dicarboxylate 
• 1277179-84-6 C₁₅H₁₉N₃O₄ 
• 1277179-85-7 C₁₅H₁₉N₃O₄ 
• 1277179-78-8 (2S,3R)-2-ethyl 3-methyl 1-((R)-1-phenylethyl)aziridine-2,3-dicarboxylate 
• 1277179-83-5 C₁₅H₁₉N₃O₄ 
• 1277179-82-4 C₁₅H₁₉N₃O₄ 
• 1277179-77-7 C₁₅H₁₉N₃O₄ 
• 1277179-75-5 C₁₅H₁₉N₃O₄ 
• 1277179-74-4 C₁₅H₁₉N₃O₄ 
• 1277179-76-6 C₁₅H₁₉N₃O₄ 

Relevant articles and documents

Stereoselective Formation of Maleic Acid Diester from Two Diazo Acetic Acid Esters on a Raney Nickel Surface. Evidence for Dipod-chemisorbed Carbenes

The N2 elimination from diazo acetic acid esters, heterogeneously catalysed by Raney Nickel, yields as chemidesorbed main product up to 93percent maleic acid diester, cis-stereoselectivity is observed and additional methyl/ethyl ester crossing experiments provide evidence for dipod-chemisorbed surface carbene intermediates.

Cyclopropanation Catalysed by RuCl2(PPh3)3 and OsCl2(PPh3)3

OsCl2(PPh3)3 is a cyclopropanation catalyst using ethyl diazoacetate with a variety of activated alkenes; OsCl2(PPh3)3 is however less active than RuCl2(PPh3)3 for the decomposition of the diazo reagent and the subsequent cyclopropanation.