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Cas Database

482-36-0

482-36-0

Identification

  • Product Name:4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3-(b-D-galactopyranosyloxy)-5,7-dihydroxy-

  • CAS Number: 482-36-0

  • EINECS:207-580-6

  • Molecular Weight:464.383

  • Molecular Formula: C21H20O12

  • HS Code:29389090

  • Mol File:482-36-0.mol

Synonyms:Hyperin(7CI,8CI);3,3',4',5,7-Pentahydroxyflavone 3-O-b-D-galactopyranoside;3-O-b-D-Galactopyranosyl quercetin;NSC 407304;Quercetin 3-O-galactopyranoside;Quercetin3-O-b-D-galactoside;Quercetin 3-O-b-galactopyranoside;Quercetin3-O-b-galactoside;Quercetin3-galactoside;Quercetin 3-b-galactoside;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowed

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:Quercetin 3-b-D-galactoside
  • Packaging:25mg
  • Price:$ 396
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Hyperoside
  • Packaging:100mg
  • Price:$ 215
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Quercetin 3-D-galactoside ≥97.0% (HPLC)
  • Packaging:1mg
  • Price:$ 118
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Quercetin 3-D-galactoside ≥97.0% (HPLC)
  • Packaging:5mg
  • Price:$ 428
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hyperoside Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100?mg
  • Packaging:100MG
  • Price:$ 699
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hyperoside United States Pharmacopeia (USP) Reference Standard
  • Packaging:50mg
  • Price:$ 1680
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Hyperoside primary reference standard
  • Packaging:25mg
  • Price:$ 454
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Quercetin3-β-D-galactoside
  • Packaging:100 mg
  • Price:$ 570
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  • Manufacture/Brand:Labseeker
  • Product Description:Quercetin 3-D-galactoside 95
  • Packaging:20mg
  • Price:$ 422
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  • Manufacture/Brand:Labseeker
  • Product Description:Quercetin 3-D-galactoside 95
  • Packaging:1g
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Relevant articles and documentsAll total 13 Articles be found

Highly Promiscuous Flavonoid 3- O-Glycosyltransferase from Scutellaria baicalensis

Wang, Zilong,Wang, Shuang,Xu, Zheng,Li, Mingwei,Chen, Kuan,Zhang, Yaqun,Hu, Zhimin,Zhang, Meng,Zhang, Zhiyong,Qiao, Xue,Ye, Min

supporting information, p. 2241 - 2245 (2019/03/19)

A highly regio-specific and donor-promiscuous 3-O-glycosyltransferase, Sb3GT1 (UGT78B4), was discovered from Scutellaria baicalensis. Sb3GT1 could accept five sugar donors (UDP-Glc/-Gal/-GlcNAc/-Xyl/-Ara) to catalyze 3-O-glycosylation of 17 flavonols, and the conversion rates could be >98%. Five new glycosides were obtained by scaled-up enzymatic catalysis. Molecular modeling and site-directed mutagenesis revealed that G15 and P187 were critical catalytic residues for the donor promiscuity. Sb3GT1 could be a promising catalyst to increase structural diversity of flavonoid 3-O-glycosides.

Efficient Synthesis of Crocins from Crocetin by a Microbial Glycosyltransferase from Bacillus subtilis 168

Ding, Fangyu,Liu, Feng,Shao, Wenming,Chu, Jianlin,Wu, Bin,He, Bingfang

, p. 11701 - 11708 (2018/11/21)

Crocins are the most important active ingredient found in Crocus sativus, a well-known "plant gold". The glycosyltransferase-catalyzed glycosylation of crocetin is the last step of biosynthesizing crocins and contributes to their structural diversity. Crocin biosynthesis is now hampered by the lack of efficient glycosyltransferases with activity toward crocetin. In this study, two microbial glycosyltransferases (Bs-GT and Bc-GTA) were successfully mined based on the comprehensive analysis of the PSPG motif and the N-terminal motif of the target plant-derived UGT75L6 and Cs-GT2. Bs-GT from Bacillus subtilis 168, an enzyme with a higher activity of glycosylation toward crocetin than that of Bc-GTA, was characterized. The efficient synthesis of crocins from crocetin catalyzed by microbial GT (Bs-GT) was first reported with a high molecular conversion rate of 81.9%, resulting in the production of 476.8 mg/L of crocins. The glycosylation of crocetin on its carboxyl groups by Bs-GT specifically produced crocin-5 and crocin-3, the important rare crocins.

Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties

Kato, Komei,Ninomiya, Masayuki,Tanaka, Kaori,Koketsu, Mamoru

supporting information, p. 1808 - 1814 (2016/08/02)

Quercetin derivatives are widespread in the plant kingdom and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of quercetin derivatives, with a focus on the influence of functional groups and sugar composition on their antioxidant capacity. A series of quercetin derivatives were therefore prepared and assessed for their DPPH radical scavenging properties. Isoquercetin O-gallates were more potent radical scavengers than quercetin. The systematic analysis highlights the importance of the distribution of hydroxy substituents in isoquercetin O-gallates to their potency.

NOVEL FLAVANONE DERIVATIVE

-

Page/Page column 35, (2012/06/18)

Provided is a novel antimicrobial agent. More specifically, provided is a novel antimicrobial agent capable of effectively acting on various resistant bacteria such as VSSA, MRSA, VISA, VRE, and VRSA. A novel flavanone derivative having a six-membered monosaccharide derivative, specifically, a glucose derivative or a galactose derivative is capable of effectively acting on the bacteria. More specifically, a compound represented by the general formula (I) is capable of effectively acting on the bacteria. (In the formula: X represents a six-membered monosaccharide derivative; and Y is substituted by a hydroxyl group.)

Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents

Hossion, Abugafar M. L.,Zamami, Yoshito,Kandahary, Rafiya K.,Tsuchiya, Tomofusa,Ogawa, Wakano,Iwado, Akimasa,Sasaki, Kenji

experimental part, p. 3686 - 3703 (2011/08/03)

A structure-guided molecular design approach was used to optimize quercetin diacylglycoside analogues that inhibit bacterial DNA gyrase and topoisomerase IV and show potent antibacterial activity against a wide spectrum of relevant pathogens responsible f

Process route upstream and downstream products

Process route

Conditions
Conditions Yield
With Glycine max (L.) Merr. cv. Clark His6-UDP-glucose:flavonoid 3-O-glucosyltransferase; at 30 ℃; for 0.05h; pH=8; regiospecific reaction; aq. buffer;
With glycosyltransferase from Bacillus subtilis 168; In aq. buffer; at 30 ℃; pH=9.5; Reagent/catalyst; regioselective reaction; Catalytic behavior; Enzymatic reaction;
With 3-O-glycosyltransferase from Scutellaria baicalensis; In aq. buffer; at 45 ℃; for 1h; pH=9; regiospecific reaction; Enzymatic reaction;
Conditions
Conditions Yield
With phosphate buffer; at 30 ℃; for 0.5h; Further Variations:; Reagents; Enzyme kinetics;
quercetin-3-O-(2″-O-galloyl)-β-galactopyranoside
53209-27-1,69624-79-9

quercetin-3-O-(2″-O-galloyl)-β-galactopyranoside

Hyperoside
482-36-0

Hyperoside

3,4,5-trihydroxybenzoic acid
149-91-7

3,4,5-trihydroxybenzoic acid

Conditions
Conditions Yield
With tannase; In water; at 37 ℃; for 2h;
3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-galactopyranosyl)-3',4',5,7-tetrahydroxyflavonol
161126-00-7

3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-galactopyranosyl)-3',4',5,7-tetrahydroxyflavonol

Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield
With sodium methylate; In methanol; at 20 ℃; for 0.5h;
87%
With sodium methylate; In methanol; at 20 ℃; for 1h;
81%
With methanol; sodium methylate; In ethyl acetate; at 20 ℃; for 0.5h;
75%
With methanol; sodium methylate;
3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-galactopyranosyl)-3',4',5,7-tetrahydroxyflavonol; With sodium methylate; In methanol; at 20 ℃; for 1.5h;
In methanol;
Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: 37 percent / 0.17 h / 180 °C
2: 31 percent / K2CO3 / dimethylformamide / 10 h / 20 °C
3: 79 percent / hydrogen / Pd/C / ethanol / 24 h / 25 °C
4: 81 percent / NaOMe / methanol / 1 h / 20 °C
With hydrogen; sodium methylate; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
Multi-step reaction with 4 steps
1: 0.08 h / 180 °C
2: K2CO3 / dimethylformamide
3: H2 / Pd/C
4: MeONa; MeOH
With methanol; hydrogen; sodium methylate; potassium carbonate; palladium on activated charcoal; In N,N-dimethyl-formamide;
2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one
357194-03-7

2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one

Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 31 percent / K2CO3 / dimethylformamide / 10 h / 20 °C
2: 79 percent / hydrogen / Pd/C / ethanol / 24 h / 25 °C
3: 81 percent / NaOMe / methanol / 1 h / 20 °C
With hydrogen; sodium methylate; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
Multi-step reaction with 3 steps
1: K2CO3 / dimethylformamide
2: H2 / Pd/C
3: MeONa; MeOH
With methanol; hydrogen; sodium methylate; potassium carbonate; palladium on activated charcoal; In N,N-dimethyl-formamide;
2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-3-(2,3,4,6-tetraacetyl-β-D-galactopyranosyl)-4H-chromen-4-one
742062-20-0

2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-3-(2,3,4,6-tetraacetyl-β-D-galactopyranosyl)-4H-chromen-4-one

Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 79 percent / hydrogen / Pd/C / ethanol / 24 h / 25 °C
2: 81 percent / NaOMe / methanol / 1 h / 20 °C
With hydrogen; sodium methylate; palladium on activated charcoal; In methanol; ethanol;
Multi-step reaction with 2 steps
1: H2 / Pd/C
2: MeONa; MeOH
With methanol; hydrogen; sodium methylate; palladium on activated charcoal;
quercetin-3-O-(6-O-galloyl)-β-gallcopyranoside
53171-28-1,56316-75-7

quercetin-3-O-(6-O-galloyl)-β-gallcopyranoside

Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield
With sodium carbonate; In methanol; dimethyl sulfoxide; at 40 ℃;
28.5 mg
quercetin 3-O-α-L-rhamnopyranosyl(1->2)-β-D-galactopyranoside

quercetin 3-O-α-L-rhamnopyranosyl(1->2)-β-D-galactopyranoside

Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield
With formic acid; cyclohexanol; for 20h; Heating;
Hyperoside
482-36-0

Hyperoside

Conditions
Conditions Yield

Global suppliers and manufacturers

Global( 111) Suppliers
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  • Kono Chem Co.,Ltd
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  • Contact Tel:86-29-86107037-8015
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  • Main Products:82
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  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:55
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:79
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  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:emmahu@up-bio.com
  • Main Products:88
  • Country:China (Mainland)
  • Leader Biochemical Group
  • Business Type:Lab/Research institutions
  • Contact Tel:86-029-68895030
  • Emails:info@leader-biogroup.com
  • Main Products:62
  • Country:China (Mainland)
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