52938-97-3

Basic information

• Product Name: 5-PHENYL-2-FUROIC ACID
• Synonyms: AKOS B025035;AKOS BAR-0049;5-PHENYL-FURAN-2-CARBOXYLIC ACID;5-PHENYL-2-FURANCARBOXYLIC ACID;5-PHENYL-2-FUROIC ACID;ART-CHEM-BB B025035;ASISCHEM V38284;LABOTEST-BB LT00569128
• CAS NO: 52938-97-3
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.18
• Product Categories: Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 52938-97-3.mol

Chemical Properties

• Melting Point: 150-154 °C(lit.)
• Boiling Point: 368.2 °C at 760 mmHg
• Flash Point: 176.5 °C
• Appearance: /
• Density: 1.254 g/cm³
• Vapor Pressure: 4.54E-06mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: 2-8°C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 5-PHENYL-2-FUROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-2-FUROIC ACID(52938-97-3)
• EPA Substance Registry System: 5-PHENYL-2-FUROIC ACID(52938-97-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 52938-97-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-PHENYL-2-FUROIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs. Its unique chemical structure allows for the creation of novel compounds with therapeutic properties.
Used in Agrochemical Industry:
5-PHENYL-2-FUROIC ACID is used as a building block in the development of agrochemicals, contributing to the creation of new compounds with potential applications in agriculture, such as pesticides or herbicides.
Used in Organic Synthesis:
5-PHENYL-2-FUROIC ACID is used as a key component in organic synthesis, enabling the formation of a wide range of organic compounds with various applications in different industries. Its versatility as a building block allows for the exploration of new chemical pathways and the synthesis of innovative molecules.

InChI:InChI=1/C11H8O3/c12-11(13)10-7-6-9(14-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 98-80-6 phenylboronic acid 
• 595-90-4 tetraphenyltin(IV) 
• 88-14-2 2-furanoic acid 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 108-86-1 bromobenzene 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 62-53-3 aniline 
• 143-66-8 sodium tetraphenyl borate 
• 52939-03-4 5-phenylfuran-2-carboxylic acid methyl ester 
• 960-16-7 tributylphenylstannane 
• 1124-19-2 phenyltin trichloride 
• 13803-39-9 5-phenylfuran-2-carbaldehyde 

Downstream Products

• 1255762-85-6 1-(5-phenylfuran-2-ylmethyl)-1H-imidazole 
• 1354698-21-7 N-5-phenyl-2-furoyl-1H-pyrazole 
• 1354698-32-0 N-5-phenyl-2-furoyl-1H-1,2,4-triazole 
• 1403473-77-7 N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-phenyl-2-furamide 
• 1403473-09-5 N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-phenyl-2-furamide hydrochloride 
• 1403473-71-1 5-phenyl-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide 
• 92972-89-9 [(5-Phenyl-furan-2-carbonyl)-amino]-acetic acid ethyl ester 

Relevant articles and documents

Furan-2-carboxamide derivative, a novel microtubule stabilizing agent induces mitotic arrest and potentiates apoptosis in cancer cells

The vital role played by microtubules in the cell division process, marks them as a potential druggable target to decimate cancer. A novel furan-2-carboxamide based small molecule, is a selective microtubule stabilizing agent (MSA) with IC50 ranging from 4 μM to 8 μM in different cancer cell lines. Inhibition of tubulin polymerization or stabilization of tubulin polymers abrogates chromosomal segregation during cell division, results in cell cycle arrest and leads to cell death due to the delayed repair mechanism. A novel furan-2-carboxamide based small molecule exhibited potent anti-proliferative and anti-metastatic property In-Vitro against the panel of cancer cells. Annexin V-FITC/PI, double staining reveals potent cytotoxic effect of SH09 against HeLa cells. FACS analysis displays induction of G2/M arrest and accumulation of subG1 population of cells upon treatment with SH09. Molecular docking study unveils SH09 binding affinity to the Taxol binding pocket of tubulin proteins and MM-GBSA also confirms strong binding energies of SH09 with tubulin proteins.

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Furan- and thiophene-2-carbonyl amino acid derivatives activate hypoxia-inducible factor via inhibition of factor inhibiting hypoxia-inducible factor-1

Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect. To activate HIF exogenously, without exposing

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains