534-26-9Relevant articles and documents
METHOD FOR PRODUCING IMIDAZOLINE COMPOUND
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Paragraph 0045; 0049-0051; 0059-0066; 0069-0070, (2021/06/04)
PROBLEM TO BE SOLVED: To provide a method for producing an imidazoline compound having high yield and small amount of impurity. SOLUTION: There is provided a method for producing an imidazoline compound (B) using a diamine monoamide compound (A) represented by the general formula (1), wherein the method includes a dehydration condensation step of the diamine monoamide compound (A) and a distillation step of the imidazoline compound (B). In the dehydration condensation step, the temperature of the dehydration condensation reaction of (A) is 100°C to 160°C in a time of 50% or more of the process time from when the conversion rate from (A) to (B) becomes 55% until when the conversion rate from (A) to (B) becomes 70%, and a the gas-phase pressure at the temperature of the dehydration condensation reaction of (A) is P1 which satisfies the conditions 1. In the distillation step, the temperature of the liquid containing (A) and (B) is 100°C to 190°C in a time of 50% or more of the process time from when 30 wt.% of the total distillate of (B) is distillated until when 90 wt.% of the total distillate of (B) is distillated, and a pressure (B) in the gas-phase of the distillation step is P2 which satisfies the condition 2. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
INTRACELLULAR DELIVERY VEHICLE
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Paragraph 0166; 0170-0171, (2020/08/13)
PROBLEM TO BE SOLVED: To provide a vehicle which can easily deliver a desired component or compound into a cell without preventing cell proliferation. SOLUTION: A intracellular delivery vehicle has its surface covered with positive electric charge. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
INTRACELLULAR DELIVERY VEHICLE
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Paragraph 0292, (2019/05/18)
An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator
Uchiyama, Seiichi,Tsuji, Toshikazu,Kawamoto, Kyoko,Okano, Kentaro,Fukatsu, Eiko,Noro, Takahiro,Ikado, Kumiko,Yamada, Sayuri,Shibata, Yuka,Hayashi, Teruyuki,Inada, Noriko,Kato, Masaru,Koizumi, Hideki,Tokuyama, Hidetoshi
supporting information, p. 5413 - 5417 (2018/04/09)
A cationic fluorescent nanogel thermometer based on thermo-responsive N-isopropylacrylamide and environment-sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C in the range 20–40 °C), and remarkable non-cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells.
Colloid and nanosized catalysts in organic synthesis: XIII. Synthesis of 2-R-2-imidazolines catalyzed by copper and iron oxide nanoparticles
Popov,Mokhov,Kalitina
, p. 281 - 285 (2016/04/20)
The reaction of carboxylic acids with ethylenediamine catalyzed by copper or iron oxide nanoparticles proceeds at 80°C with azeotropic water distilling off during 2-8 h to form 2-R-2-imidazolines. Acyl and diacyl derivatives of ethylenediamine are formed in the reaction as side products.
Push-pull alkenes by reacting N,N′-dimethyl cyclic ketene N,N′-acetals with isocyanates: synthesis, structures, and reactivities
Ye, Guozhong,Henry, William P.,Chen, Chunlong,Zhou, Aihua,Pittman Jr., Charles U.
supporting information; experimental part, p. 2135 - 2139 (2009/07/26)
N,N′-Dimethyl cyclic ketene N,N′-acetals react with two or three equivalents of isocyanates to generate tetrasubstituted push-pull alkene derivatives in one-pot sequential reactions. X-ray crystallography showed significant elongations and out of plane distorsions of the polarized carbon-carbon double bonds.
Easy access to triazoles, triazolopyrimidines, benzimidazoles and imidazoles from imidates
Zarguil,Boukhris,El Efrit,Souizi,Essassi
body text, p. 5883 - 5886 (2009/04/05)
We have described a new and easy synthesis of triazoles, triazolopyrimidines, benzimidazoles and imidazoles variously substituted based on the reaction of imidates with diamine derivatives. The products were obtained in moderate to good yields. A general mechanism for the reactions is proposed.
Synthesis of aldehydes from carboxylic acids via 2-imidazolines
Shi, Zhen,Gu, Huan
, p. 2701 - 2707 (2007/10/03)
The use of readily available 2-substituted-2-imidazolines as precursors to 2-hydroxy aldehyde, unsaturated aldehyde and a variety of functionalized aldehydes is reported. It provides a novel method for the preparation of aldehydes from carboxylic acids via 2-substituted-2-imidazolines.
Copper(I)-induced addition of amines to unactivated nitriles: The first general one-step synthesis of alkyl amidines
Rousselet,Capdevielle,Maumy
, p. 6395 - 6398 (2007/10/02)
Cu(I)Cl promotes the condensation of acetonitrile 1a and benzonitrile 1b with primary and secondary amines 2a-g into amidines 3a-j under mild conditions, in high to quantitative yields. Stoichiometric formation of Cu(I)-amidines complexes allows to control the degree of substitution of resulting amidines.
