5432-19-9Relevant articles and documents
Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids
Frost, John R.,Jacob, Nicholas T.,Papa, Louis J.,Owens, Andrew E.,Fasan, Rudi
, p. 1805 - 1816 (2015/09/01)
A versatile method for orchestrating the formation of side chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Upon ribosomal incorporation into intein-containing precursor proteins, designer unnatural amino acids be
Streptogramins for preparing same by mutasynthesis
-
, (2008/06/13)
The invention provides a method for preparing streptogramins using genetically-modified microorganisms to influence the biosynthesis of at least one of the precursors of the group B streptogramins. Cultures of the genetically-modified microorganisms are supplemented with a least one precursor that is different from the streptogramin precursor whose biosynthesis is altered and the streptogramins produced are recovered.
Gonadotropin-Releasing Hormone Antagonists: Novel Members of the Azaline B Family
Rivier, Jean E.,Jiang, Guangcheng,Porter, John,Hoeger, Carl A.,Craig, A. Grey,et al.
, p. 2649 - 2662 (2007/10/03)
A series of antagonists of gonadotropin-releasing hormone (GnRH) homologous to azaline B (1, DCpa2, DPal3, Aph5(Atz), DAph6(Atz), ILys8, DAla10>GnRH) was synthesized, cha
