54551-83-6Relevant articles and documents
Synthesis and bio-evaluation of natural butenolides-acrylate conjugates
Bao, Longzhu,Wang, Shuangshuang,Song, Di,Wang, Jingjing,Cao, Xiufang,Ke, Shaoyong
, (2019/04/05)
A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L?1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.
ANTI-HCMV COMPOSITIONS AND METHODS
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Page/Page column 84; 85, (2016/06/06)
This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.
Double-stranded supramolecular assembly through salt bridge formation between rigid and flexible amidine and carboxylic acid strands
Iida, Hiroki,Shimoyama, Munenori,Furusho, Yoshio,Yashima, Eiji
supporting information; experimental part, p. 417 - 423 (2010/04/02)
(Chemical Equation Presented) A series of monomeric strands consisting of m-terphenyl backbones with chiral rigid C-linked (3) and flexible N-linked (5) formamidines and achiral carboxylic acid (4) and flexible carboxymethyl (6) residues were synthesized, and their duplex formations through amidinium-carboxylate salt bridges were investigated by NMR, circular dichroism (CD), and UV-visible spectroscopies. The salt bridge-derived duplex formation was largely dependent on the structures of the formamidine and carboxylic acid strands, and the C-linked formamidine strand 3 formed a more stable duplex with the complementary carboxylic acid strands (4 and 6) than did the flexibleN-linked formamidine strand 5. The single crystal X-ray analysis revealed that the duplex 5·4 has a skewed right-handed double helical structure. A complementary duplex dimer was also synthesized from the dimers of 5 and 4 joined by diacetylene linkers. Variable-temperature CD measurements indicated that the duplex possesses a dynamic double helical structure resulting from the flexible N-linked formamidine units.
Inhibitors of α4 mediated cell adhesion
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, (2008/06/13)
The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, —O-(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur, W is oxygen, sulfur, —CH═CH—, —NH— or —N═CH—; R1, R2and R3are the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; R4is tetrazolyl, carboxyl group, amide or ester; R5is hydrogen, nitro, amino, hydroxyl, lower alkanoyl, lower alkyl etc.; R6is selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstituted benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.
1,2-disubstituted-6-oxo-3-phenyl-piperidine-3-carboxamides and combinatorial libraries thereof
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, (2008/06/13)
The invention relates to combinatorial libraries containing two or more novel piperidine-3-carboxamide derivative compounds, methods of preparing the piperidine-3-carboxamide derivative compounds and piperidine-3-carboxamide derivative compounds bound to a resin
Homologation of carboxylic acids by Arndt-Eistert reaction under ultrasonic waves
Winum, Jean-Yves,Kamal, Merhnaz,Leydet, Alain,Roque, Jean-Pierre,Montero, Jean-Louis
, p. 1781 - 1782 (2007/10/03)
The use of ultrasonic activation in the Arndt-Eistert reaction leads rapidly, in good yields, to the expected compounds at room temperature.
The Synthesis of 1,8-Disubstituted 10,11-Dihydrodibenzoxepin-10-ones. Analogues of Anaesthetic Steroids
Burden, Peter M.,Capper, Hugh R.,Allan, Robin D.,Johnston, Graham A. R.
, p. 3291 - 3294 (2007/10/02)
1,8-Disubstituted 10,11-dihydrodibenzoxepin-10-ones 4a, b and 5a, b have been synthesized as analogues of steroid anaesthetics 2 and 3 respectively.The novel partial Ullmann reaction between methyl 2,6-dichlorophenylacetate 7 and 4-substituted phenols 8a, b gave diphenyl ether derivatives 9a, b.The latter were then hydrolysed and cyclodehydrated to give 1,8-disubstituted 10,11-dihydrodibenzoxepin-10-ones 11a, b which underwent selective funtional group transformations to give 4a, 5a and 4b, 5b respectively.Lithium borohydride reduction of the ester 13b to the benzyl alcohol 14b proceeded without reduction of the enol ether function.
Substituted phenylacetylguanidines: a new class of antihypertensive agents
Bream,Lauener,Picard,Scholtysik,White
, p. 1477 - 1482 (2007/10/05)
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N amidino 2 (2,6 dichlorophenyl) acetamide hydrochloride [2,6 dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure activity relationships in this class of compounds are discussed.