555-57-7Relevant articles and documents
Microwave-Assisted Cu(I)-Catalyzed Synthesis of Unsymmetrical 1,4-Diamino-2-butynes via Cross-A3-Coupling/Decarboxylative A3-Coupling
Xu, Xianjun,Feng, Huangdi,Van Der Eycken, Erik V.
, p. 14036 - 14043 (2021/05/29)
1,4-Diamino-2-butynes display both chemical and physiological properties. Here a highly efficient synthesis avenue to generate unsymmetric 1,4-diamino-2-butynes has been developed by microwave-assisted Cu(I)-catalyzed cross-A3-coupling/decarboxylative coupling of two different amines, formaldehyde, and propiolic acid through a domino process. This multicomponent reaction provides a series of target products in moderate to good yields with high chemoselectivity.
N-Propargylation of secondary amines directly using calcium carbide as an acetylene source
Fu, Rugang,Li, Zheng
, p. 341 - 345 (2017/06/19)
A one-pot N-propargylation of secondary amines has been achieved by heating the amine with formaldehyde and calcium carbide in DMSO in the presence of CuCl as a catalyst. Fifteen examples of propargylic tertiary amines, 12 of which are novel, were efficiently prepared in yields of 65-84%. The advantages of the method are broad substrate scope and a simple work-up procedure.
A 1,3-amino group migration route to form acrylamidines
Chauhan, Dinesh Pratapsinh,Varma, Sreejith Jayasree,Vijeta, Arjun,Banerjee, Pallavi,Talukdar, Pinaki
supporting information, p. 323 - 325 (2014/01/06)
A novel 1,3-amino group migration strategy for the synthesis of acrylamidines is presented. Cu(i) catalyzed reaction of N,N-disubstituted propargylamine with tosylazide generates a highly reactive ketenimine intermediate which is trapped by a tethered amino group leading to the rearrangement reaction.
