58415-38-6Relevant articles and documents
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
Sinha, Shweta,Doble, Mukesh,Manju
, p. 34 - 50 (2018/09/13)
Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi
Expanding the donor-acceptor toolbox with a minimal 5-(thiophen-2-yl)-1,3-thiazole core: Transition metal-free synthesis and molecular design for HOMO-LUMO energy modulations
Radhakrishnan, Rakesh,Sreejalekshmi, Kumaran G.
supporting information, p. 3036 - 3039 (2016/05/09)
Synthesis of a minimal 5-(thiophen-2-yl)-1,3-thiazole core through a transition metal-free, versatile [4+1] route is reported. DFT calculations on a prototype library of D-A-D-A tetrads established the exquisite HOMO-LUMO energy modulation by varying peri
Crystal structures and antimicrobial and cytotoxic activities of zinc(II), nickel(II) and copper(II) complexes of N-(piperidylthiocarbonyl)benzamide
Xie, Juan,Cheng, Zhongqin,Yang, Wen,Liu, Huanhuan,Zhou, Weiqun,Li, Mengying,Xu, Yunlong
, p. 157 - 164 (2015/03/30)
A new zinc(II) complex of N-(piperidylthiocarbonyl)benzamide, [ZnL2], has been synthesized and characterized using elemental analysis, Fourier transform infrared and 1H NMR spectroscopies. X-ray diffraction indicates that [ZnL2
Crystal structures and antifungal activities of fluorine-containing thioureido complexes with nickel(II)
Li, Chun,Yang, Wen,Liu, Huanhuan,Li, Mengying,Zhou, Weiqun,Xie, Juan
, p. 15737 - 15749 (2014/01/17)
Ni(II) complexes with N-2-fluorobenzoylpiperidine-1-carbothioimidate (L2-), N-4-fluorobenzoylpiperidine-1-carbothioimidate (L3-), N-2- fluorobenzoylmorpholine- 1-carbothioimidate (L5-) and N-4- fluorobenzoylmorpholine-1-carbothioimidate (L6-) have been synthesized and characterized by elemental analysis, FTIR and 1H-NMR. The crystal structures of three ligands (HL2, HL3 and HL6) and the corresponding Ni(II) complexes ([Ni(L2)2], [Ni(L3)2] and [Ni(L6)2]) have been determined by X-ray diffraction. The antifungal activities of the Ni(II) complexes together and the corresponding ligands against the fungi Botrytis cinerea, Trichoderma spp., Myrothecium and Verticillium spp. have been investigated. The experimental results showed that the ligands and their complexes have antifungal abilities. When the fluorine was substituted on the para-benzoyl moiety, the antifungal activity of the ligands was obviously increased. Moreover, the ligands were stronger than their complexes in inhibiting fungal activities. The antifungal ability of HL6 is especially strong, and similar to that of the commercial fungicide fluconazole.
Efficient one-pot synthesis of alkyl 2-(dialkylamino)-4-phenylthiazole-5- carboxylates and single-crystal x-ray structure of methyl 2-(diisopropylamino)- 4-phenylthiazole-5-carboxylate
Souldozi, Ali,Ramazani, Ali,Dadrass, Ali Reza,Slepokura, Katarzyna,Lis, Tadeusz
scheme or table, p. 339 - 348 (2012/04/10)
The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5- carboxylates in fairly high yi
Facile synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1,2,4-oxadiazoles from acylthiourea
Chennakrishnareddy, Gundala,Debasis, Hazra,Jayan, Rapai,Manjunatha, Sulur G.
, p. 6170 - 6173 (2011/11/30)
Facile and selective synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1,2,4-oxadiazoles starting from N-acylthioureas has been demonstrated. The regio-selectivity is achieved by simply selecting an appropriate base used for the generation of hydroxyl amine fro
A rapid, four-component synthesis of functionalized thiazoles
Sabbaghan, Maryam,Alidoust, Mostafa,Hossaini, Zinatossadat
, p. 824 - 828 (2012/04/23)
An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl) (phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.
Silica-gel-catalyzed conversion of stabilized phosphorus ylides to benzo[e][1,3]thiazocin derivatives
Souldozi, Ali,Dadrass, Ali Reza
experimental part, p. 1921 - 1925 (2010/11/19)
The reaction between triphenylphosphine, dialkylacetylenedicarboxylates, and N-benzoyl thiourea derivatives leads to intermediates such as vinyltriphenylphosphonium salts, which undergo Michael addition to produce the highly functionalized phosphorus ylid
One-pot synthesis of functionalized thioureas by reaction of benzoyl isothiocyanates, secondary amines, and alkyl propiolates
Yavari, Issa,Sayyed-Alangi, S. Zahra,Sabbaghan, Maryam,Hajinasiri, Rahimeh,Iravani, Nasir
experimental part, p. 1025 - 1028 (2009/11/30)
An efficient one-pot synthesis of functionalized thioureas is described via three-component reaction of benzoyl isothiocyanates, secondary amines, and alkyl propiolates in the presence of triphenylphosphine (20∈mol%).
Versatile novel syntheses of imidazoles
Rolfs, Andreas,Liebscher, Juergen
, p. 3480 - 3487 (2007/10/03)
A novel ring transformation/desulfurization of substituted 2-methyl-1,2,4-thiadiazolium salts 2 provides a versatile entry to imidazoles 3 with a variety of substituents. Simple one-pot procedures combine the preparation of starting 1,2,4-thiadiazolium salts 2 from N-(thiocarbonyl)-N'-methylamidines 1 or 1,2,4-dithiazolium triiodides 6 with the ring transformation/desulfurization to the imidazoles 3. Alternatively, N-(thiocarbonyl)-N'-methylamidines 1 can be transformed to imidazoles 3 or to 1-substituted imidazoles 5 via S-methylation and elimination of methylthiol. In the same manner, a new entry to 4H-imidazoles 8 could be developed.
