58518-08-4

Basic information

• Product Name: 3-Butyn-2-one, 1,1,1-trifluoro-4-phenyl-
• Synonyms: 4-phenyl-1,1,1-trifluorobut-3-yn-2-one;1,1,1-trifluoro-4-phenyl-but-3-yn-2-one;1-trifluoromethyl-1-oxo-3-phenyl-propyne;3-Butyn-2-one,1,1,1-trifluoro-4-phenyl;1,1,1-trifluoro-4-phenyl-3-butyn-2-one
• CAS NO: 58518-08-4
• Molecular Formula: C10H5F3O
• Molecular Weight: 198.144
• Mol File: 58518-08-4.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: 3-Butyn-2-one, 1,1,1-trifluoro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-2-one, 1,1,1-trifluoro-4-phenyl-(58518-08-4)
• EPA Substance Registry System: 3-Butyn-2-one, 1,1,1-trifluoro-4-phenyl-(58518-08-4)

Safety Data

• Hazardous Substances Data: 58518-08-4(Hazardous Substances Data)

Upstream product

• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 89524-12-9 1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butyne 
• 459-72-3 ethyl 2-fluoroacetate 
• 536-74-3 phenylacetylene 
• 52843-77-3 phenylethynyl trifluoromethyl sulfone 
• 407-25-0 trifluoroacetic anhydride 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 4440-01-1 lithium phenylacetylide 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 130307-88-9 2-Hydroxy-4-phenyl-2-trifluormethylbut-3-insaeureethylester 
• 4890-63-5 (phenylethynyl)magnesium chloride 
• 502607-33-2 2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoic acid 

Downstream Products

• 114389-80-9 1-phenyl-3-(trifluoromethyl)hept-1-yn-3-ol 
• 114389-79-6 (Z)-4-phenyl-1,1,1-trifluorooct-3-en-2-one 
• 114389-78-5 (E)-4-phenyl-1,1,1-trifluorooct-3-en-2-one 
• 89524-12-9 1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butyne 
• 129633-18-7 (Z)-1,1,1-Trifluoro-4-(3-methoxy-phenylamino)-4-phenyl-but-3-en-2-one 
• 129633-17-6 (Z)-4-(3-Chloro-phenylamino)-1,1,1-trifluoro-4-phenyl-but-3-en-2-one 
• 114389-75-2 2-cyano-4-phenyl-1,1,1-trifluorobut-3-yn-2-ol 
• 114389-76-3 2-cyano-4-phenyl-1,1,1-trifluoropent-3-en-2-ol 
• 114389-73-0 (Z)-4-phenyl-1,1,1-trifluoropent-3-en-2-one 
• 114389-72-9 (E)-1,1,1-trifluoro-4-phenylpent-3-en-2-one 
• 86571-26-8 1,1,1-trifluoro-4-phenylbutan-2-one 
• 62847-45-4 5-phenyl-3-(trifluoromethyl)isoxazole 

Relevant articles and documents

REACTION OF UNSYMMETRICAL FLUORINATED β-DIKETONES WITH DIHALOPHOSPHORANES: THE SYNTHESIS OF α,β-YNONES

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Direct Catalytic Asymmetric Vinylogous Additions of α,β- and β,γ-Butenolides to Polyfluorinated Alkynyl Ketimines

We report a Zn-ProPhenol catalyzed asymmetric Mannich reaction between butenolides and polyfluorinated alkynyl ketimines to obtain vinylogous products featuring two contiguous tetrasubstituted stereogenic centers. Notably, this is the first successful use

Organometal-Free Arylation and Arylation/Trifluoroacetylation of Quinolines by Their Reaction with CF3-ynones and Base-Induced Rearrangement

The reaction of quinolines with CF3-ynones resulted in the formation of 1,3-oxazinoquinolines. Subsequent treatment of the reaction mixture with a base initiated deep structural transformation of primary products. Both steps proceed in very high yield. As a result, unusual rearrangement of 1,3-oxazinoquinolines to form either 2-arylquinolines or 2-aryl-3-trifluoroacetylquinolines was discovered. The decisive role of the base in the reaction direction was shown. Using these reactions, highly efficient pathways to 2-arylquinolines and 2-aryl-3-trifluoroacetylquinolines were elaborated to provide the corresponding compounds in high yields using a simple one-pot procedure. The possible mechanism of rearrangement is discussed.

Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP

A general method to access CF3-substituted allenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent is described. By tuning the reaction time and temperature, the obtained allenes rearr