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59937-01-8

59937-01-8

Identification

  • Product Name:RARECHEM AL BI 1318

  • CAS Number: 59937-01-8

  • EINECS:

  • Molecular Weight:233.291

  • Molecular Formula: C12H11 N O2 S

  • HS Code:2934100090

  • Mol File:59937-01-8.mol

Synonyms:2-Phenylthiazole-4-carboxylicacid ethyl ester

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Matrix Scientific
  • Product Description:Ethyl 2-phenyl-1,3-thiazole-4-carboxylate 97%
  • Packaging:1g
  • Price:$ 260
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:Ethyl2-phenylthiazole-4-carboxylate 95+%
  • Packaging:10g
  • Price:$ 582
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:Ethyl2-phenylthiazole-4-carboxylate 95+%
  • Packaging:5g
  • Price:$ 350
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:Ethyl2-phenyl-1,3-thiazole-4-carboxylate 95%
  • Packaging:10g
  • Price:$ 597
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  • Manufacture/Brand:Chemenu
  • Product Description:Ethyl2-phenyl-1,3-thiazole-4-carboxylate 95%
  • Packaging:5g
  • Price:$ 341
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  • Manufacture/Brand:Ark Pharm
  • Product Description:Ethyl 2-phenylthiazole-4-carboxylate 97%
  • Packaging:5g
  • Price:$ 224
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  • Manufacture/Brand:Ark Pharm
  • Product Description:Ethyl 2-phenylthiazole-4-carboxylate 97%
  • Packaging:1g
  • Price:$ 70
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  • Manufacture/Brand:Ark Pharm
  • Product Description:Ethyl 2-phenylthiazole-4-carboxylate 97%
  • Packaging:10g
  • Price:$ 381
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-PHENYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 95.00%
  • Packaging:5MG
  • Price:$ 500.93
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:Ethyl2-phenylthiazole-4-carboxylate 97%
  • Packaging:250mg
  • Price:$ 43
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Relevant articles and documentsAll total 32 Articles be found

Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) family

Fang, Lincheng,Hu, Zhaoxue,Yang, Yifei,Chen, Pan,Zhou, Jinpei,Zhang, Huibin

supporting information, (2021/04/15)

Bromodomain and extra-terminal (BET) is a promising therapeutic target for various hematologic cancers. We used the BRD4 inhibitor compound 13 as a lead compound to develop a variety of compounds, and we introduced diverse groups into the position of the compound 13 orienting toward the ZA channel. A series of compounds (14–23, 38–41, 43, 47–49) bearing triazolopyridazine motif exhibited remarkable BRD4 protein inhibitory activities. Among them, compound 39 inhibited BRD4(BD1) protein with an IC50 of 0.003 μM was superior to lead compound 13. Meanwhile, compound 39 possess activity, IC50 = 2.1 μM, in antiproliferation activity against U266 cancer cells. On the other hand, compound 39 could arrest tumor cells into the G0/G1 phase and induce apoptosis, which was consistent with its results in inhibiting cell proliferation. Biological and biochemical data suggest that BRD4 protein might be a therapeutic target and that compound 39 is an excellent lead compound for further development.

INHIBITORS OF HUMAN ATGL

-

Page/Page column 208-209, (2021/02/05)

The present invention relates to novel inhibitors of adipose triglyceride lipase (ATGL) having an improved inhibitory activity against human ATGL (hATGL) as well as pharmaceutical compositions comprising these inhibitors, and their therapeutic use, particularly in the treatment or prevention of a lipid metabolism disorder, including, e.g., obesity, non-alcoholic fatty liver disease, type 2 diabetes, insulin resistance, glucose intolerance, hypertriglyceridemia, metabolic syndrome, cardiac and skeletal muscle steatosis, congenital generalized lipodystrophy, familial partial lipodystrophy, acquired lipodystrophy syndrome, atherosclerosis, or heart failure.

Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors

Xu, Xue,Deng, Liming,Nie, Lu,Chen, Yueming,Liu, Yanzhi,Xie, Rongrong,Li, Zheng

supporting information, p. 525 - 528 (2019/01/09)

The xanthine oxidase (XO) plays an important role in producing uric acid, and therefore XO inhibitors are considered as one of the promising therapies for hyperuricemia and gout. We have previously reported a series of XO inhibitors with pyrazole scaffold to extend the chemical space of current XO inhibitors. Herein, we describe further structural optimization to explore the optimal heterocycle by replacing the thiazole ring of Febuxostat with 5 heterocycle scaffolds unexplored in this field. All of these efforts resulted in the identification of compound 8, a potent XO inhibitor (IC50 = 48.6 nM) with novel 2-phenylthiazole-4-carboxylic acid scaffold. Moreover, lead compound 8 exhibited hypouricemic effect in potassium oxonate-hypoxanthine-induced hyperuricemic mice. These results promote the understanding of ligand-receptor interaction and might help to design more promising XO inhibitors.

Process route upstream and downstream products

Process route

Ethyl 5,5-dihydro-2-phenyl-2-thiazoline-4-carboxylate
70454-09-0

Ethyl 5,5-dihydro-2-phenyl-2-thiazoline-4-carboxylate

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With oxygen; copper diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; under 760.051 Torr; Molecular sieve;
92%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

benzenecarbothioamide
2227-79-4

benzenecarbothioamide

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
In ethanol; at 20 ℃; for 2h; Reflux;
94%
With sodium carbonate; In neat (no solvent); Milling;
85%
In ethanol; for 4h; Reflux;
76%
In ethanol; for 6h; Reflux;
74%
In ethanol; for 3h; Reflux;
71%
In ethanol; for 2h; Reflux;
70%
In ethanol; at 78 ℃; for 5h;
69%
In N,N-dimethyl-formamide; for 15h; Ambient temperature;
41%
In ethanol;
In ethanol; at 90 ℃;
In ethanol; at 70 ℃;
In ethanol; for 6h; Reflux;
In ethanol; for 3h; Reflux;
In ethanol; Reflux;
In ethanol; for 4h; Reflux;
0.52 g
In ethanol; at 80 ℃;
ethyl 2-bromothiazole-4-carboxylate
100367-77-9

ethyl 2-bromothiazole-4-carboxylate

phenylboronic acid
98-80-6

phenylboronic acid

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; at 60 ℃; for 18h; Schlenk technique; Inert atmosphere;
61%
2-bromo-5-chlorothiazole-4-carboxylic acid ethyl ester
425392-44-5

2-bromo-5-chlorothiazole-4-carboxylic acid ethyl ester

phenylboronic acid
98-80-6

phenylboronic acid

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

5-chlorothiazole-4-carboxylic acid ethyl ester
425392-45-6

5-chlorothiazole-4-carboxylic acid ethyl ester

5-chloro-2-phenylthiazole-4-carboxylic acid ethyl ester
425392-46-7

5-chloro-2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0); In toluene; at 80 ℃; for 4h;
81%
L-cysteine ethyl ester hydrochloride
868-59-7

L-cysteine ethyl ester hydrochloride

benzaldehyde
100-52-7

benzaldehyde

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With tert.-butylhydroperoxide; iodine; potassium carbonate; In 1,4-dioxane; at 70 ℃; for 12h; Reagent/catalyst; Solvent; Catalytic behavior; Schlenk technique; Molecular sieve; Inert atmosphere;
88%
L-cysteine ethyl ester hydrochloride; benzaldehyde; With sodium hydrogencarbonate; In ethanol; water; at 60 ℃; for 8h;
With [bis(acetoxy)iodo]benzene; In dichloromethane; at 40 ℃; for 4h;
78%
ethyl bromopyruvate

ethyl bromopyruvate

benzenecarbothioamide
2227-79-4

benzenecarbothioamide

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
In ethanol; for 4h; Reflux;
76%
4-hydroxy-2-phenyl-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester
37128-20-4

4-hydroxy-2-phenyl-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Molecular sieve;
91%
ethyl (4R)-2-phenyl-4,5-dihydrothiazole-4-carboxylate
89530-19-8

ethyl (4R)-2-phenyl-4,5-dihydrothiazole-4-carboxylate

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Molecular sieve;
77%
2-benzoylamino-3-oxo-propionic acid ethyl ester
80548-05-6

2-benzoylamino-3-oxo-propionic acid ethyl ester

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With Lawessons reagent; In 1,4-dioxane; for 12h; Reflux;
(2RS,4R)-2-phenylthiazolidine-4-carboxylic acid ethyl ester
189228-43-1

(2RS,4R)-2-phenylthiazolidine-4-carboxylic acid ethyl ester

2-phenylthiazole-4-carboxylic acid ethyl ester
59937-01-8

2-phenylthiazole-4-carboxylic acid ethyl ester

Conditions
Conditions Yield
With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; for 6h; Heating;
72.9%

Global suppliers and manufacturers

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  • GIHI CHEMICALS CO.,LIMITED
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  • Kono Chem Co.,Ltd
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  • SAGECHEM LIMITED
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  • Huayang chemical Co., LTD
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  • Amadis Chemical Co., Ltd.
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  • Beyond Pharmaceutical Co., Ltd
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  • yuyongmei
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