616-29-5

Basic information

• Product Name: 1,3-Diamino-2-propanol
• Synonyms: 1,3-diamino-2-propano;1,3-DIAMINO-2-HYDROXYPROPAN;1,3-DIAMINO-2-HYDROXYPROPANE;1,3-DIAMINO-2-PROPANOL;1,3-DIAMINOPROPAN-2-OL;2-HYDROXY-1,3-DIAMINOPROPANE;1,3-Diamino-2-hydroxypropane, tech;2-hydroxy-1,3-propylenediamine
• CAS NO: 616-29-5
• Molecular Formula: C₃H₁₀N₂O
• Molecular Weight: 90.12
• EINECS: 210-474-2
• Product Categories: Aliphatics;Amines
• Mol File: 616-29-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 40-44 °C(lit.)
• Boiling Point: 235°C
• Flash Point: >230 °F
• Appearance: White to yellow/Low Melting Solid
• Density: 1.0352 (rough estimate)
• Vapor Pressure: 0.00844mmHg at 25°C
• Refractive Index: 1.4610 (estimate)
• Storage Temp.: 2-8°C
• Solubility: water: soluble1g/10 mL
• PKA: 9.69, 7.93(at 20℃)
• Water Solubility: Very soluble in water.
• BRN: 741859
• CAS DataBase Reference: 1,3-Diamino-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diamino-2-propanol(616-29-5)
• EPA Substance Registry System: 1,3-Diamino-2-propanol(616-29-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: 3259
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 616-29-5(Hazardous Substances Data)

Usage

Uses

1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.It is a precursor to synthesize the fluorogenic dsDNA binder, N1,N3-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).It can also be used as a branching unit in the synthesis of peptide dendrimers.

Purification Methods

Dissolve it in an equal amount of water, shake it with charcoal and distil it at 68o/0.1mm. The distillate solidifies. It is too viscous to be distilled through a packed column. [Beilstein 4 IV 1694.]

InChI:InChI=1/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2/p+2

Upstream product

• 57011-48-0 1,3-diazido 2-propanol 
• 106-89-8 epichlorohydrin 
• 7647-01-0 hydrogenchloride 
• 73825-95-3 N,N'-(2-hydroxy-propanediyl)-bis-phthalimide 
• 10035-10-6 hydrogen bromide 
• 96-23-1 1,3-Dichloro-2-propanol 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 
• 5455-98-1 2-oxiranylmethylisoindole-1,3-dione 

Downstream Products

• 88635-66-9 5-methoxysalicylaldehyde-2-hydroxy-1,3-propanediamine 
• 54622-43-4 2-hydroxypropylene-1,3-diamino-N,N,N',N'-tetramethylenephosphonic acid 
• 155168-37-9 3-[{3-[Bis-(2-phenoxycarbonyl-ethyl)-amino]-2-hydroxy-propyl}-(2-phenoxycarbonyl-ethyl)-amino]-propionic acid phenyl ester 
• 80239-63-0 N-(3-amino-2-hydroxypropyl)-2-(tritylamino)acetamide 
• 122413-32-5 N,N,N',N'-tetrakis(2-pyridylmethyl)-1,3-diamino-2-propanol 
• 140873-07-0 C₂₀H₃₂N₆O₂ 
• 16087-33-5 3-{(E)-2-Hydroxy-3-[1-methyl-3-oxo-3-phenyl-prop-(E)-ylideneamino]-propylimino}-1-phenyl-butan-1-one 
• 138404-89-4 3-Cyclohexyl-N-[3-(3-cyclohexyl-propionylamino)-2-hydroxy-propyl]-propionamide 
• 138404-87-2 N-[2-Hydroxy-3-(3-phenyl-propionylamino)-propyl]-3-phenyl-propionamide 
• 1852-18-2 tetrahydro-5-hydroxy-2(1H)-pyrimidinone 
• 106871-02-7 N,N'-bis(1-methyl-3-hydroxy-3-phenyl-2-propen-1-ylidene)-1,3-diamino-2-propanol 
• 566201-36-3 C₄₅H₆₆N₆O₁₅ 
• 651734-20-2 7-(3-Amino-2-hydroxy-propylamino)-1-cyclopentyl-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one 
• 726191-15-7 3-[N-(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]-5-nitrobenzoic acid 

Relevant articles and documents

Method for preparing polyamine by direct ammoniation of polyhydroxy compound

A method for preparing polyamine by direct ammoniation of a polyhydroxy compound is disclosed. By using a polyhydroxy compound, ammonia gas or liquefied ammonia as a raw material and using a carrier-loaded liquid-phase reduced transition metal as a catalyst, an ammoniation reaction of the polyhydroxy compound under mild conditions is realized. The catalyst has high selectivity of polyamine. The catalyst can be recovered and recycled.

A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines

N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.

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