620-80-4

Basic information

• Product Name: 2-Acetyl-3-phenylacrylic acid ethyl ester
• Synonyms: 2-Acetyl-3-phenylacrylic acid ethyl ester;2-Acetyl-3-phenylpropenoic acid ethyl ester;2-Benzylidene-3-oxobutanoic acid ethyl ester;2-Benzylidene-3-oxobutyric acid ethyl ester;α-Acetylbenzeneacrylic acid ethyl ester;α-Benzylideneacetoacetic acid ethyl;Ethyl2-benzylideneacetoacetate;ethyl 2-benzylidene-3-oxobutanoate
• CAS NO: 620-80-4
• Molecular Formula: C₁₃H₁₄O₃
• Molecular Weight: 218.2485
• Mol File: 620-80-4.mol
• Article Data: 101

Chemical Properties

• Melting Point: 60.5°C
• Boiling Point: 296°C (estimate)
• Flash Point: 111.9°C
• Appearance: /
• Density: 1.1367 (rough estimate)
• Vapor Pressure: 0.00147mmHg at 25°C
• Refractive Index: 1.5090 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Acetyl-3-phenylacrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetyl-3-phenylacrylic acid ethyl ester(620-80-4)
• EPA Substance Registry System: 2-Acetyl-3-phenylacrylic acid ethyl ester(620-80-4)

Safety Data

• Hazardous Substances Data: 620-80-4(Hazardous Substances Data)

Usage

General Description

2-Acetyl-3-phenylacrylic acid ethyl ester, also known as ethyl 3-phenylacryloylacetate, is a chemical compound commonly used in the production of fragrances and flavorings. It is a yellow liquid with a sweet, floral odor and is often added to perfumes, colognes, and other scented products. 2-Acetyl-3-phenylacrylic acid ethyl ester is also used as a starting material in organic synthesis to produce various pharmaceuticals and agrochemicals. It is considered to be a versatile building block in the chemical industry due to its ability to undergo various chemical reactions and produce a wide range of different molecules. Additionally, it has been found to have potential antioxidant and anti-inflammatory properties, making it a subject of interest in the field of medicinal chemistry.

InChI:InChI=1/C13H14O3/c1-3-16-13(15)12(10(2)14)9-11-7-5-4-6-8-11/h4-9H,3H2,1-2H3

Upstream product

• 108-86-1 bromobenzene 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 100-46-9 benzylamine 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 100-52-7 benzaldehyde 
• 87696-57-9 ethyl 2-(trimethylsilyl)-3-methyl-3-pentenoate 
• 76-05-1 trifluoroacetic acid 
• 104-15-4 toluene-4-sulfonic acid 
• 4124-41-8 p-toluenesulfonylanhydride 
• 75-75-2 methanesulfonic acid 
• 4418-61-5 5-aminotetrazole 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 17572-39-3 2,4-diethoxycarbonyl-5-hydroxy-5-methyl-3-phenylcyclohexanone 
• 19419-23-9 2,2'-phenylmethylene-bis(5,5-dimethylcyclohexane-1,3-dione) 
• 96708-13-3 3,4,5-triphenyl-cyclohex-2-en-1-one 
• 10285-14-0 (+/-)-trans-1.2.3-triphenyl-cyclohexen-⁽³⁾-one-⁽⁵⁾ 
• 23138-81-0 2-(dimethoxyphosphoryl-phenyl-methyl)-3-oxo-butyric acid ethyl ester 
• 10387-94-7 2,6-diphenyl-5,6-dihydropyrimidin-4(3H)-one 
• 108262-44-8 3-Ethoxycarbonyl-2-phenyl-4-oxopentanenitrile 
• 4439-87-6 2-phenyllevulinic acid 
• 876474-32-7 2-cyclohexylmethyl-3-hydroxy-butyric acid ethyl ester 
• 858782-18-0 2-benzyl-3-hydroxy-butyric acid ethyl ester 
• 16430-09-4 3-methyl-4-(1-phenylmethylidene)-5-isoxazolone 
• 1165-06-6 Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Cs-Beta with an Al-rich composition as a highly active base catalyst for Knoevenagel condensation

Ion-exchange of an Al-rich zeolite beta, synthesized by organic structure-directing agent-free method (Beta-OF), was studied for application as a base catalyst. While the as-synthesized Beta-OF in Na-form itself had base sites and showed moderate catalyti

Knoevenagel condensation reactions catalysed by metal-organic frameworks

Functionalised metal-organic frameworks (MOFs) which contain amino groups on their secondary building units (SBUs) are basic catalysts in the Knoevenagel condensation. University of Michigan Crystalline Material-1-amine (UMCM-1-NH2), Isoreticul

TRIMETHYLCHLOROSILANE - A NEW REAGENT FOR THE KNOEVENAGEL REACTION

-

Asymmetric Synthesis of Pentasubstituted Cyclohexanes through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction

An asymmetric domino Michael/Michael reaction of α,β-unsaturated aldehydes 1 and α-acetyl-β-substituted-α,β-unsaturated esters 2 catalyzed by diphenylprolinol silyl ether was developed. This is a formal carbo [4+2] cycloaddition reaction affording penta-s

Highly active hybrid mesoporous silica-supported base organocatalysts for C–C bond formation

New base hybrid catalysts, based on silyl-derivatives of molecules carrying amino, diamino, pyrrolidine, pyrazolium and imidazolium functionalities have been successfully achieved through post synthetic grafting onto M41S-type support. Different character