6276-48-8Relevant articles and documents
Asymmetric Ir-catalyzed hydrogenation of 1,5-benzodiazepinones using mixtures of ligands
Lyubimov,Ozolin,Davankov
, p. 1059 - 1061 (2017/10/31)
The catalytic hydrogenation of benzodiazepinones using metal complexes with phosphite and phosphoramidite ligands was carried out for the first time. The mixed-ligand catalytic systems containing a chiral phosphoramidite or phosphite in combination with an achiral phosphine were shown to exhibit a higher enantioselectivity compared to catalysts containing homocombinations of chiral ligands.
Synthesis of highly regioselective bifunctional tricyclic tetrazole-1 H -benzo[ b ][1,4]diazepins
Shaabani, Ahmad,Hezarkhani, Zeinab,Mofakham, Hamid,Ng, Seikweng
, p. 1485 - 1492 (2013/08/23)
A new approach for the synthesis of arrays of bifunctional tricyclic tetrazole-1H-benzo[b][1,4]diazepines has been investigated. It includes a sequential two-step isocyanide-based condensation reaction of diamines or 2-nitroanilines, ethyl 3-oxobutanoate or 2,2,6-trimethyl-4H-1,3-dioxin-4-one, isocyanides and trimethylsilyl azide in good yields. Georg Thieme Verlag Stuttgart · New York.
A facile and efficient synthesis of arylsulfonamido-substituted 1,5-benzodiazepines and N-[2-(3-benzoylthioureido)aryl]-3-oxobutanamide derivatives
Alizadeh, Abdolali,Zohreh, Nasrin
experimental part, p. 1221 - 1226 (2010/08/21)
A facile and efficient synthesis of 1,5-benzodiazepines with an arylsulfonamido substituent at C(3) is described. 1,5-Benzodiazepine, derived from the condensation of benzene-1,2-diamine and diketene, reacts with an arylsulfonyl isocyanate via an enamine intermediate to produce the title compounds of potential synthetic and pharmacological interest in good yields (Scheme 1). In addition, reaction of benzene-1,2-diamine and diketene in the presence of benzoyl isothiocyanate leads to N-[2-(3-benzoylthioureido)aryl]-3- oxobutanamide derivatives (Scheme 2). This reaction proceeds via an imine intermediate and ring opening of diazepine. The structures were corroborated spectroscopically (IR, 1Hand 13C-NMR, and EI-MS) and by elemental analyses. A plausible mechanism for this type of cyclization is proposed (Scheme 3).