Welcome to LookChem.com Sign In|Join Free

Cas Database

637031-88-0

637031-88-0

Identification

Synonyms:3,3-difluorocyclobutanol

Post Buying Request Now

Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:3,?3-?Difluorocyclobutanol
  • Packaging:100mg
  • Price:$ 165
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3,3-Difluorocyclobutan-1-ol
  • Packaging:1 g
  • Price:$ 775
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:3,3-Difluorocyclobutanol
  • Packaging:1g
  • Price:$ 851
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:J&W Pharmlab
  • Product Description:3,3-Difluoro-cyclobutanol 97%
  • Packaging:500mg
  • Price:$ 125
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:ChemScene
  • Product Description:3,3-Difluorocyclobutanol 99.53%
  • Packaging:1g
  • Price:$ 135
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:ChemScene
  • Product Description:3,3-Difluorocyclobutanol 99.53%
  • Packaging:250mg
  • Price:$ 54
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:ChemScene
  • Product Description:3,3-Difluorocyclobutanol 99.53%
  • Packaging:5g
  • Price:$ 527
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:3,3-difluorocyclobutan-1-ol 95%+
  • Packaging:10g
  • Price:$ 1265
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:3,3-difluorocyclobutan-1-ol 95%+
  • Packaging:5g
  • Price:$ 770
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:3,3-difluorocyclobutan-1-ol 95%+
  • Packaging:1g
  • Price:$ 262
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 2 Articles be found

Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

Melnykov, Kostiantyn P.,Granat, Dmitriy S.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.

, p. 4949 - 4957 (2018/12/13)

An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert -butyl or benzyl vinyl ether should be applied.

Process route upstream and downstream products

Process route

(3,3-difluorocyclobutoxymethyl)benzene
637031-86-8

(3,3-difluorocyclobutoxymethyl)benzene

3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

Conditions
Conditions Yield
With hydrogen; 10% palladium on activated carbon; In diethyl ether; at 20 ℃; for 5h; under 15001.5 Torr;
With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr; Inert atmosphere;
3.37 g
C<sub>8</sub>H<sub>14</sub>F<sub>2</sub>O

C8H14F2O

3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

Conditions
Conditions Yield
With hydrogenchloride; In 1,4-dioxane; at 60 ℃;
7.97 g
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

dimethyl diazomalonate
6773-29-1

dimethyl diazomalonate

dimethyl 2-(3,3-difluorocyclobutoxy)malonate

dimethyl 2-(3,3-difluorocyclobutoxy)malonate

Conditions
Conditions Yield
With dirhodium tetraacetate; In dichloromethane; at 20 ℃; Inert atmosphere;
86%
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

4-bromo-phenol
106-41-2

4-bromo-phenol

1-bromo-4-(3,3-difluorocyclobutoxy)benzene

1-bromo-4-(3,3-difluorocyclobutoxy)benzene

Conditions
Conditions Yield
3,3-difluorocyclobutan-1-ol; With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; Inert atmosphere;
4-bromo-phenol; In toluene; at 100 ℃; Inert atmosphere;
92%
With triphenylphosphine; diethylazodicarboxylate; In toluene; at 100 ℃; for 16h; Inert atmosphere;
16%
With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 100 ℃;
3,3-difluorocyclobutan-1-ol; With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; for 0.166667h;
4-bromo-phenol; In toluene; at 100 ℃;
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

C<sub>14</sub>H<sub>11</sub>FO<sub>2</sub>

C14H11FO2

C<sub>18</sub>H<sub>16</sub>F<sub>2</sub>O<sub>3</sub>

C18H16F2O3

Conditions
Conditions Yield
With caesium carbonate; In N,N-dimethyl-formamide; at 25 - 60 ℃; for 3h;
74.6%
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

4-(2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide
1618663-97-0

4-(2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

4-(2-chloro-4-(3,3-difluorocyclobutoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide
1618664-00-8

4-(2-chloro-4-(3,3-difluorocyclobutoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

Conditions
Conditions Yield
With sodium t-butanolate; In 1,4-dioxane; at 70 ℃; for 16h; Inert atmosphere; Sealed tube;
64.1%
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

2-chloro-5-(2,6-dichlorophenyl)-6H-pyrimido[1,6-b]pyridazin-6-one

2-chloro-5-(2,6-dichlorophenyl)-6H-pyrimido[1,6-b]pyridazin-6-one

5-(2,6-dichlorophenyl)-2-(3,3-difluorocyclobutoxy)-6H-pyrimido[1,6-b]pyridazin-6-one

5-(2,6-dichlorophenyl)-2-(3,3-difluorocyclobutoxy)-6H-pyrimido[1,6-b]pyridazin-6-one

Conditions
Conditions Yield
With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
41%
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

tert-butyl 3-(4-hydroxyphenyl)azetidine-1-carboxylate

tert-butyl 3-(4-hydroxyphenyl)azetidine-1-carboxylate

tert-butyl 3-[4-(3,3-difluorocyclobutoxy)phenyl]azetidine-1-carboxylate

tert-butyl 3-[4-(3,3-difluorocyclobutoxy)phenyl]azetidine-1-carboxylate

Conditions
Conditions Yield
With triphenylphosphine; diethylazodicarboxylate; In toluene; at 100 ℃; for 12h; Inert atmosphere;
25.5%
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

C<sub>14</sub>H<sub>13</sub>NO<sub>3</sub>S

C14H13NO3S

C<sub>18</sub>H<sub>17</sub>F<sub>2</sub>NO<sub>3</sub>S

C18H17F2NO3S

Conditions
Conditions Yield
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 35 ℃; for 12h; Inert atmosphere;
21%
3,3-difluorocyclobutan-1-ol
637031-88-0

3,3-difluorocyclobutan-1-ol

4-[3-(2,2,2-trifluoroethyl)benzotriazol-5-yl]phenol

4-[3-(2,2,2-trifluoroethyl)benzotriazol-5-yl]phenol

C<sub>18</sub>H<sub>14</sub>F<sub>5</sub>N<sub>3</sub>O

C18H14F5N3O

Conditions
Conditions Yield
With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 65 ℃; for 24h; Inert atmosphere;
14.69 mg
With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 65 ℃; for 24h; Inert atmosphere;
14.69 mg

Global suppliers and manufacturers

Global( 42) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:79
  • Country:China (Mainland)
  • Bluecrystal chem-union
  • Business Type:Trading Company
  • Contact Tel:+86-1895157
  • Emails:bluecrystalchem@163.com
  • Main Products:7
  • Country:China (Mainland)
  • Win-Win chemical Co.Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
  • Country:China (Mainland)
  • BOC Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
  • Main Products:41
  • Country:United States
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:33
  • Country:China (Mainland)
  • Chemlyte Solutions
  • Business Type:Other
  • Contact Tel:+86-189 8945 5137
  • Emails:sales@chemlytesolutions.com
  • Main Products:203
  • Country:China (Mainland)
  • Debye Scientific
  • Business Type:Lab/Research institutions
  • Contact Tel:+85221376140
  • Emails:sales@debyesci.com
  • Main Products:13
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 637031-88-0
Post Buying Request Now
close
Remarks: The blank with*must be completed