6395-57-9Relevant articles and documents
Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily
Van Loo, Bert,Bayer, Christopher D.,Fischer, Gerhard,Jonas, Stefanie,Valkov, Eugene,Mohamed, Mark F.,Vorobieva, Anastassia,Dutruel, Celine,Hyv?nen, Marko,Hollfelder, Florian
supporting information, p. 370 - 387 (2019/01/08)
Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions. We employ a systematic comparative study of structure, sequence, and sub
CHOLINESTERASE INHIBITORS
-
Paragraph 0139-0141, (2014/02/15)
The invention provides compounds that inhibit cholinesterases, such as acetylcholinesterase and butyrylcholinesterase. Such compounds are useful to prevent or treat exposure of a patient (e.g., a human) to an organophosphoric nerve agent (e.g., sarin and
One pot synthesis of diastereomeric phosphonates
Saxena, Shefali,Sharma, Mamta,Purnanand
, p. 259 - 266 (2007/10/03)
The reaction of diaryl methylphosphonate with sterically hindered alcohols in presence of sodium hydride provide arylalkyl methylphosphonate esters with high diastereoselectivity at the phosphorus center.