6443-85-2

Basic information

• Product Name: 3-PYRIDYLACETONITRILE
• Synonyms: PYRIDINE-3-ACETONITRILE;3-PYRIDINEACETONITRILE;3-PYRIDYLACETONITRILE;3-PYRIDYLMETHYL CYANIDE;3-(CYANOMETHYL)PYRIDINE;3-Pyridinylacetonitrile;Pyridine-3-acetonitrile,98%;NSC 83226
• CAS NO: 6443-85-2
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.14
• EINECS: 229-241-1
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;pharmacetical;Building Blocks;C7 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines
• Mol File: 6443-85-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 99-100 °C
• Boiling Point: 101-109 °C1.5 mm Hg(lit.)
• Flash Point: 209 °F
• Appearance: very deep yellow/Liquid
• Density: 1.108 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00511mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Storage Temp.: 2-8°C
• PKA: 4.17±0.10(Predicted)
• Water Solubility: Soluble in alcohol, ether, ketone. Insoluble in water.
• BRN: 111292
• CAS DataBase Reference: 3-PYRIDYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDYLACETONITRILE(6443-85-2)
• EPA Substance Registry System: 3-PYRIDYLACETONITRILE(6443-85-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 26-36
• RIDADR: 3276
• WGK Germany: 3
• F: 10
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6443-85-2(Hazardous Substances Data)

Usage

Uses

3-Pyridineacetonitrile is a reactant used in the preparation of 1,7-naphthyridine derivatives as phosphodiesterase-4 inhibitors.

InChI:InChI=1/C7H6N2/c8-4-3-7-2-1-5-9-6-7/h1-2,5-6H,3H2

Upstream product

• 143-33-9 sodium cyanide 
• 6959-48-4 3-chloromethylpyridinium chloride 
• 626-55-1 3-Bromopyridine 
• 1120-90-7 3-iodopyridine 
• 42545-63-1 2-(pyrid-3-yl)acetaldehyde 
• 59020-10-9 3-(tributylstannyl)pyridine 
• 105-56-6 ethyl 2-cyanoacetate 
• 501-81-5 pyridyl-3-yl-acetic acid 
• 773837-37-9 sodium cyanide 
• 100-55-0 3-hydroxymethylpyridin 
• 110-86-1 pyridine 
• 75-05-8 acetonitrile 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 144205-15-2 C₁₆H₁₆N₄⁽²⁺⁾*2Br^(1-) 

Downstream Products

• 51451-44-6 2-pyridin-3-yl-thioacetamide 
• 6635-88-7 3-(cyanomethyl)pyridine 1-oxide 
• 127667-26-9 2-(Cyano-pyridin-3-yl-methyl)-benzonitrile 
• 144061-50-7 2-(3-pyridylmethyl)-3,6-tetramethylbenzonitrile 
• 144061-51-8 2-(3-pyridylmethyl)-6-methoxy-3-methylbenzonitrile 
• 25230-06-2 3-Pyridylmalononitrile 
• 144061-49-4 2-(3-pyridylmethyl)-3,4,5,6-tetramethylbenzonitrile 
• 119-65-3 isoquinoline 
• 92060-41-8 (Z)-3-phenyl-2-(pyridin-3-yl)acrylonitrile 
• 6529-37-9 4-phenyl-2-(pyridin-3-yl)butyronitrile 
• 144467-13-0 2-(3-Pyridyl)-3-phenyl-5-oxohexanenitrile 
• 5562-24-3 3-Cyanomethyl-1-methyl-pyridinium; iodide 

Relevant articles and documents

Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides

α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 °C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Two-step cyanomethylation protocol: Convenient access to functionalized aryl- and heteroarylacetonitriles

A two-step protocol has been developed for the introduction of cyanomethylene groups to metalated aromatics through the intermediacy of substituted isoxazoles. A palladium-mediated cross-coupling reaction was used to introduce the isoxazole unit, followed by release of the cyanomethylene function under thermal or microwave-assisted conditions. The intermediate isoxazoles were shown to be amenable to further functionalization prior to deprotection of the sensitive cyanomethylene motif, allowing access to a wide range of aryl- and heteroaryl-substituted acetonitrile building blocks.