65326-33-2

Basic information

• Product Name: 2-Amino-3-acetylpyridine
• Synonyms: 3-ACETYL-2-AMINOPYRIDINE;2-AMINO-3-ACETYLPYRIDINE;1-(2-AMINO-PYRIDIN-3-YL)-ETHANONE;1-(2-Aminopyridin-3-yl)ethan-1-one;3-acetylpyridin-2-amine;1-(2-amino-3-pyridinyl)-1-ethanone;Ethanone, 1-(2-amino-3-pyridinyl)-;1-(2-Aminopyridin-3-yl)ethan-1-one, 2-Amino-3-ethanoylpyridine
• CAS NO: 65326-33-2
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• Product Categories: Pyridine
• Mol File: 65326-33-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-140°C
• Boiling Point: 283.8 °C at 760 mmHg
• Flash Point: 125.5 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 0.00309mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.73±0.36(Predicted)
• CAS DataBase Reference: 2-Amino-3-acetylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-acetylpyridine(65326-33-2)
• EPA Substance Registry System: 2-Amino-3-acetylpyridine(65326-33-2)

Safety Data

• Hazard Codes: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 65326-33-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow powder

InChI:InChI=1/C7H8N2O/c1-5(10)6-3-2-4-9-7(6)8/h2-4H,1H3,(H2,8,9)

Upstream product

• 372-48-5 2-fluoropyridine 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 75-16-1 methylmagnesium bromide 
• 131674-39-0 2-chloro-3-(1-hydroxyethyl)pyridine 
• 109-09-1 2-chloropyridine 
• 79574-61-1 1-(2-Fluoro-3-pyridyl)ethanol 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 161987-58-2 1-(2-pivaloylaminopyridin-3-yl)ethanone 
• 79574-70-2 1-(2-fluoropyridin-3-yl)ethan-1-one 
• 55676-21-6 3-acetyl-2-chloropyridine 

Downstream Products

• 165467-16-3 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylic acid 
• 161987-61-7 ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate 
• 161987-62-8 2-bromoethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate 
• 213666-98-9 3-(prop-1-en-2-yl)pyridin-2-amine 

Relevant articles and documents

Nickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes

An unprecedented asymmetric acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochemistry and asymmetric transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.

Improved Synthesis of 2,3-Disubstituted Pyridines by Metallation of 2-Chloropyridine: a Convenient Route to Fused Polyheterocycles

Chemoselective directed metallation of 2-chloropyridine allows the synthesis of 2-substituted 3-carbonylated pyridines, advantage being taken of the metallation ortho-directing effect of the halogen, as well as its reactivity towards nucleophiles.Thus (2-chloro-, 2-methoxy-, and 2-amino-3-pyridyl)-ethanones and -arylmethanones as well as carbaldehydes have been prepared.Some of these ortho-disubstituted intermediates have been readily cyclized to fused polyheterocycles such as naphthiridines and aza-analoges of coumarins, xanthones, and acridones.