6633-61-0

Basic information

• Product Name: Methyl 2-aminothiazole-5-carboxylate
• Synonyms: METHYL 2-AMINO-1,3-THIAZOLE-5-CARBOXYLATE;METHYL 2-AMINOTHIAZOLE-5-CARBOXYLATE;2-AMINO-THIAZOLE-5-CARBOXYLIC ACID METHYL ESTER;RARECHEM AL BF 1263;5-Thiazolecarboxylic acid, 2-amino-, methyl ester;Methyl 2-Aminothioazole-5-carboxylate;Methyl 2-aminothiazole-5-carboxylate ,97%;2-Amino-5-(methoxycarbonyl)-1,3-thiazole
• CAS NO: 6633-61-0
• Molecular Formula: C₅H₆N₂O₂S
• Molecular Weight: 158.18
• EINECS: 1312995-182-4
• Product Categories: Amines;blocks;Carboxes;Thiazoles;Amino Acids and Derivatives;Heterocycles;Aromatics;Miscellaneous Reagents;Sulfur & Selenium Compounds
• Mol File: 6633-61-0.mol

Chemical Properties

• Melting Point: 182-186°C
• Boiling Point: 298.731 °C at 760 mmHg
• Flash Point: 134.468 °C
• Appearance: /
• Density: 1.408 g/cm³
• Vapor Pressure: 4.76E-10mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.02±0.10(Predicted)
• CAS DataBase Reference: Methyl 2-aminothiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-aminothiazole-5-carboxylate(6633-61-0)
• EPA Substance Registry System: Methyl 2-aminothiazole-5-carboxylate(6633-61-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 6633-61-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-aminothiazole-5-carboxylate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can contribute to the development of new drugs with potential therapeutic applications, such as antibiotics, anti-inflammatory agents, and other therapeutic molecules.
Used in Organic Synthesis:
Methyl 2-aminothiazole-5-carboxylate is used as a key building block in organic synthesis for the creation of complex organic molecules. Its unique structure allows for a variety of reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and condensation reactions, which can lead to the formation of diverse chemical entities with potential applications in various industries.
Used in Chemical Research:
Methyl 2-aminothiazole-5-carboxylate is used as a research compound in the field of chemistry, particularly in the study of thiazole-containing molecules and their properties. Its reactivity and structural features make it an interesting subject for exploring new reaction pathways, understanding reaction mechanisms, and developing novel synthetic strategies.

InChI:InChI=1/C22H23NO3/c1-2-26-22(25)20-16-23(21(24)18-11-7-4-8-12-18)14-13-19(20)15-17-9-5-3-6-10-17/h3-12,16,19H,2,13-15H2,1H3

Upstream product

• 20656-61-5 methyl 2-chloro-3-oxopropionate 
• 17356-08-0 thiourea 
• 107-31-3 Methyl formate 
• 96-34-4 methyl chloroacetate 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 

Downstream Products

• 52499-04-4 2-aminothiazole-5-carboxamide 
• 40283-46-3 2-aminothiazole-5-carboxylic acid 
• 72605-86-8 2-chlorothiazole-5-carboxylic acid methyl ester 
• 14527-44-7 methyl thiazole-5-carboxylate 
• 881384-32-3 2-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]thiazole-5-carboxylic acid methyl ester 
• 1082605-11-5 C₁₃H₉FN₂O₂S 
• 1151240-82-2 methyl 2-[({1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl}carbonyl)amino]-1,3-thiazole-5-carboxylate 
• 1228304-55-9 methyl 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylate 
• 1334496-16-0 methyl 2-(2-(methoxycarbonyl)benzamido)thiazole-5-carboxylate 
• 1334496-13-7 methyl 2-(diphenoxyphosphorylamino)thiazole-5-carboxylate 
• 1416811-23-8 C₂₂H₂₂Cl₂N₄O₅S 
• 1416811-50-1 methyl 2-[(2S)-2-amino-3-phenylpropanamido]-1,3-thiazole-5-carboxylate 
• 1416810-29-1 C₂₃H₁₉ClN₄O₄S 
• 1416810-37-1 C₂₄H₂₂N₄O₅S 

Relevant articles and documents

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PCT No. PCT/US94/09139 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 23, 1994 PCT Pub. No. WO95/06030 PCT Pub. Date Mar. 2, 1995The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as human immunodeficiency virus.

Studies on Decarboxylation Reactions. Part 7. Kinetic Study of the Decarboxylation of 2-Amino- and 2-Phenylamino-thiazole-5-carboxylic Acids

The rate constants of the decarboxylation reaction of 2-amino- and 2-phenylamino-thiazole-5-carboxylic acid (3a-b), and, for comparison, of 5-phenylamino-1,3,4-thiadiazole-2-carboxylic acid (2b) have been measured in water over a range of proton activities.The results obtained suggest: (i) compound 2b decarboxylates, in the whole range of proton activity studied, through a unimolecular decarboxyprotonation mechanism characteristic of 1,3,4-oxa- and 1,3,4-thiadiazole derivatives; (ii) in contrast, 3a-b decarboxylate via either a unimolecular decarboxyprotonation or a bimolecular protiodecarboxylation mechanism as a function of proton activity.