67696-28-0

Basic information

• Product Name: Benzene, [(2,2,2-trifluoroethoxy)methyl]-
• CAS NO: 67696-28-0
• Molecular Formula: C9H9F3O
• Molecular Weight: 190.165
• Mol File: 67696-28-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, [(2,2,2-trifluoroethoxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(2,2,2-trifluoroethoxy)methyl]-(67696-28-0)
• EPA Substance Registry System: Benzene, [(2,2,2-trifluoroethoxy)methyl]-(67696-28-0)

Safety Data

• Hazardous Substances Data: 67696-28-0(Hazardous Substances Data)

Upstream product

• 1547-96-2 2,4,6-tris(2,2,2-trifluoroethoxy)-1,3,5-triazine 
• 100-51-6 benzyl alcohol 
• 75-89-8 2,2,2-trifluoroethanol 
• 100-39-0 benzyl bromide 
• 501-53-1 benzyl chloroformate 
• 64-17-5 ethanol 
• 75399-88-1 bis(2,2,2-trifluoroethoxy)tris(dimethylamino)phosphorane 
• 75399-87-0 bis(2,2,2-trifluoroethoxy)tri-n-butylphosphorane 
• 25236-64-0 2,2,2-trifluoroethyl methanesulfonate 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 25370-91-6 N-benzyl-N'-(4-toluenesulfonyloxy)diimide N-oxide 
• 540-72-7 sodium thiocyanide 
• 1024-41-5 benzyl tosylate 
• 127-09-3 sodium acetate 

Downstream Products

• 1015236-33-5 1,1-difluoroprop-1-en-2-yl 4-methylbenzenesulfonate 
• 100-51-6 benzyl alcohol 
• 1350432-94-8 C₉H₉F₂⁽¹⁸⁾FO 

Relevant articles and documents

Expedient and efficient one pot synthesis of trifluoroethyl ethers from metal free 2,4,6-tris-(2,2,2-trifluoro-ethoxy)-[1,3,5] triazene

An efficient synthesis of fluorinated alkyl and aryl ethers was achieved by the use of s-triazene derived fluorinated reagent 2,4,6-tris-(2,2,2-trifluoro-ethoxy)-[1,3,5] triazene (TriTFET). The procedure offers a very attractive alternative for the synthesis of fluorinated motifs that are found in various bioactive molecules. Moreover, TriTFET is a synthetic non-toxic, non-ozone depleting and stable reagent. All compounds were characterized by 1H, 13C and 19F NMR.

A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups

A procedure for the radiosynthesis of aliphatic [18F] trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [ 18F]fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[18F]F, has been developed. A variety of 18F-labelled model compounds were then obtained and two potential [18F]radiotracers were synthesised by a two step process starting from 1,1-difluorovin-2-yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.

Gem-difluorinated homoallyl alcohols, β-hydroxy ketones, and syn- and anti-1, 3-diols via γ,γ-difiuoroallylboronates

γ,γ-Difluoroallylboronates have been prepared from trifluoroethanol and utilized for the allylboration of a variety of aldehydes to provide gem-difluorinated homoallylic alcohols. α-Chiral aldehydes were allylborated in 4:1-13:1 diastereoselectivity favoring the anti-isomer. A representative series of difluorinated hydroxyl enol ethers were converted to the corresponding α, α-difluoro-β-hydroxy ketones. Diastereoselective reduction of one of these to either syn- and anti-1,3-diol was also studied.