67696-28-0Relevant articles and documents
Expedient and efficient one pot synthesis of trifluoroethyl ethers from metal free 2,4,6-tris-(2,2,2-trifluoro-ethoxy)-[1,3,5] triazene
Mangawa, Shrawan Kumar,Sharma, Chiranjeev,Singh, Ashawani Kumar,Awasthi, Satish K.
, p. 35042 - 35045 (2015/05/04)
An efficient synthesis of fluorinated alkyl and aryl ethers was achieved by the use of s-triazene derived fluorinated reagent 2,4,6-tris-(2,2,2-trifluoro-ethoxy)-[1,3,5] triazene (TriTFET). The procedure offers a very attractive alternative for the synthesis of fluorinated motifs that are found in various bioactive molecules. Moreover, TriTFET is a synthetic non-toxic, non-ozone depleting and stable reagent. All compounds were characterized by 1H, 13C and 19F NMR.
A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups
Riss, Patrick J.,Aigbirhio, Franklin I.
supporting information; experimental part, p. 11873 - 11875 (2011/12/04)
A procedure for the radiosynthesis of aliphatic [18F] trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [ 18F]fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[18F]F, has been developed. A variety of 18F-labelled model compounds were then obtained and two potential [18F]radiotracers were synthesised by a two step process starting from 1,1-difluorovin-2-yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.
Gem-difluorinated homoallyl alcohols, β-hydroxy ketones, and syn- and anti-1, 3-diols via γ,γ-difiuoroallylboronates
Ramachandran, P. Veeraraghavan,Chatterjee, Anamitra
supporting information; experimental part, p. 1195 - 1198 (2009/04/07)
γ,γ-Difluoroallylboronates have been prepared from trifluoroethanol and utilized for the allylboration of a variety of aldehydes to provide gem-difluorinated homoallylic alcohols. α-Chiral aldehydes were allylborated in 4:1-13:1 diastereoselectivity favoring the anti-isomer. A representative series of difluorinated hydroxyl enol ethers were converted to the corresponding α, α-difluoro-β-hydroxy ketones. Diastereoselective reduction of one of these to either syn- and anti-1,3-diol was also studied.