6835-16-1

Basic information

• Product Name: HYOSCYAMINE SULFATE
• Synonyms: Hyoscyamine Sulfate (125 mg);[3(S)-ENDO]-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, ALPHA-(HYDROXYMETHYL)-BENZENEACETIC ACID SULFATE DIHYDRATE;HYOSCYAMINE SULFATE DIHYDRATE;HYOSCYAMINE SULPHATE;HYOSCYAMINE SULFATE;BENZENEACETIC ACID, ALPHA-(HYDROXYMETHYL)-, 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, [3(S)-ENDO]-, SULFATE (2:1), DIHYDRATE;HYOSCYAMINESULFATE,USP;HOSCYAMINE SULFATE USP
• CAS NO: 6835-16-1
• Molecular Formula: 2C₁₇H₂₃NO₃*H₂O₄S
• Molecular Weight: 712.85
• EINECS: 210-644-6
• Mol File: 6835-16-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 206° when dry
• Appearance: /
• Solubility: Very soluble in water, sparingly soluble or soluble in ethanol (96 per cent).
• CAS DataBase Reference: HYOSCYAMINE SULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: HYOSCYAMINE SULFATE(6835-16-1)
• EPA Substance Registry System: HYOSCYAMINE SULFATE(6835-16-1)

Safety Data

• Hazardous Substances Data: 6835-16-1(Hazardous Substances Data)

Usage

Chemical Properties

[a]D -24o mp >200 oC toxic solid

Uses

Different sources of media describe the Uses of 6835-16-1 differently. You can refer to the following data:
1. Anticholinergic.
2. Hyoscyamine Sulfate Dihydrate is a derivative of (-)-Hycosamine(H674300) is a natural compound that has inhibitory activity against cholinesterases.

InChI:InChI=1/2C17H23NO3.H2O4S/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t2*13-,14?,15+,16?;/m00./s1

Synthetic route

atropine sulfate (5908-99-6, 55-48-1, 300-40-3, 620-61-1, 1867-24-9, 2472-17-5, 2623-69-0, 14844-27-0) → (R)-atropine sulfate + (S)-atropine sulfate (6835-16-1)

Conditions	Yield
With chiral monolith prepared by thiol-ene click reaction of allyl-β-cyclodextrin with pentaerythritol tetra-(3-mercaptopropionate) In acetonitrile for 0.216667h; pH=4; Resolution of racemate;

Upstream product

• 5908-99-6 atropine sulfate 
• 120-29-6 3-tropanol 
• 51-55-8 Atropine 
• 5894-79-1 methyl 2-formyl-2-phenylacetate 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 

Downstream Products

• 529-64-6 Tropic acid 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 500-55-0 apoatropine 

Relevant articles and documents

Synthesis method of atropine sulfate

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of atropine sulfate. The preparation method comprises the following steps: firstly preparing tropine ester, then preparing atropine, salifying to prepare atropine sulfate, and finally refining to obtain the product. In the preparation process of the tropine ester, the reaction temperature is strictly controlled to be 105-111 DEG C, and the crystallization temperature is controlled to be 0-5 DEG C, so that the yield of the tropine ester is improved. In the process of preparing atropine through reduction reaction, palladium-carbon is adopted as a catalyst, and the reaction temperature is strictly controlled to be 10-15 DEG C, so that the product quality is effectively improved. Sulfuric acid is diluted by preparing a sulfuric acid ethanol solution, and the dripping speed of the sulfuric acid ethanol solution is controlled, so that the stable quality of atropine sulfate is ensured.

Facile one-pot preparation of chiral monoliths with a well-defined framework based on the thiol-ene click reaction for capillary liquid chromatography

A novel chiral cyclodextrin (CD) monolith was easily prepared via a one-pot process based on the thiol-ene click reaction of allyl-β-CD with pentaerythritol tetra-(3-mercaptopropionate) in a fused-silica capillary. The effects of both the composition of prepolymerization solution and reaction temperature on the morphology, permeability, and selectivity of the β-CD chiral monolith were investigated in detail. The conditions were optimized to fabricate a homogeneous and permeable chiral monolith. In this study, the β-CD monolith was used as the stationary phase of capillary liquid chromatography for the chiral separation of several pharmaceutical enantiomers including flavanone, flurbiprofen, naproxen, synephrine, isoprenaline sulfate, ketoprofen, and atropine sulfate monohydrate. Compared to the previously reported two-step method, this one-pot method for the preparation of a β-CD chiral monolith is simple and time-saving. Moreover, good resolutions were obtained for chiral isomers in a shorter analysis time compared to that reported in the literatures. These results indicate that the thiol-ene click chemistry provides a simple and robust method for the preparation of a chiral β-CD monolith.