5908-99-6 Usage
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 5908-99-6 differently. You can refer to the following data:
1. Atropine sulfate is mydriatic; antispasmodic; used in preanesthetic medication.
2. Anticholinergic;Muscarinic antagonist
3. mydriatic and anticholinergie agent in ophthalmie preparations and pre-anesthetie medications; antidote to organophosphous
insecticides
General Description
Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.
Biological Activity
atropine is a competitive antagonist of muscarinic acetylcholine receptor with ic50 values of 2.22±0.60nm, 4.32±1.63nm, 4.16±1.04nm, 2.38±1.07nm and 3.39±1.16nm for m1, m2, m3, m4 and m5, respectively [1].atropine is an antimuscarinic agent and has shown the pharmacological effects because of binding to muscarinic acetylcholine receptors. atropine, the orthosteric antagonist, has been reported to compete with [3h]-nms for all muscarinic subtypes with a potency consistent with the high affinities at the machr subtypes. the ki values are 1.27±0.36nm, 3.24±1.16nm, 2.21±0.53nm, 0.77±0.43nm and 2.84±0.84nm, respectively [1, 2, 3].
references
[1] lebois ep1, bridges tm, lewis lm, dawson es, kane as, xiang z, jadhav sb, yin h, kennedy jp, meiler j, niswender cm, jones ck, conn pj, weaver cd, lindsley cw. discovery and characterization of novel subtype-selective allosteric agonists for the investigation of m(1) receptor function in the central nervous system.acs chem neurosci. 2010;1(2):104-121.[2] busch h, allen h, anderson dc.effects of atropine and carbachol on labeling of protein fractions of mouse pancreas in vitro.j pharmacol exp ther. 1959 nov; 127:200-4.[3] feron o1, smith tw, michel t, kelly ra.dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. j biol chem. 1997 jul 11; 272(28):17744-8.
Check Digit Verification of cas no
The CAS Registry Mumber 5908-99-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,0 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5908-99:
(6*5)+(5*9)+(4*0)+(3*8)+(2*9)+(1*9)=126
126 % 10 = 6
So 5908-99-6 is a valid CAS Registry Number.
InChI:InChI=1/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15?,16?;;
5908-99-6Relevant articles and documents
Synthesis method of atropine sulfate
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, (2021/09/01)
The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of atropine sulfate. The preparation method comprises the following steps: firstly preparing tropine ester, then preparing atropine, salifying to prepare atropine sulfate, and finally refining to obtain the product. In the preparation process of the tropine ester, the reaction temperature is strictly controlled to be 105-111 DEG C, and the crystallization temperature is controlled to be 0-5 DEG C, so that the yield of the tropine ester is improved. In the process of preparing atropine through reduction reaction, palladium-carbon is adopted as a catalyst, and the reaction temperature is strictly controlled to be 10-15 DEG C, so that the product quality is effectively improved. Sulfuric acid is diluted by preparing a sulfuric acid ethanol solution, and the dripping speed of the sulfuric acid ethanol solution is controlled, so that the stable quality of atropine sulfate is ensured.
An anti-choline medicine preparation method of atropine sulfate
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, (2017/03/08)
The invention provides a synchronizing method of atropine sulphate. The method is characterized in that hydrolyzing methyl phenoxyacetate (II) is hydrolyzed to obtain a compound (III); the compound (III) and thionyl chloride are subjected to acylation reaction to obtain a compound (IV); the compound (IV) and 8-methyl-8-azabicyclo[3.2.1]oct-3-alchol are subjected to condensation reaction to obtain a compound (V); the compound (V) and paraformaldehyde are used for producing atropine (VI) under an alkaline condition; the atropine (VI) is salified under an acidic condition to obtain the atropine sulphate (I). The preparation method is simple in technology, high in yield, high in purity, low in monomer impurity and easy for industrial production.
