Hyoscyamine sulfate

Base Information

• Chemical Name: Hyoscyamine sulfate
• CAS No.: 6835-16-1
• Molecular Formula: C34H52N2O12S
• Molecular Weight: 387.454
• Hs Code.: 2939800000
• Mol file: 6835-16-1.mol

Synonyms:[3(S)-ENDO]-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, ALPHA-(HYDROXYMETHYL)-BENZENEACETIC ACID SULFATE DIHYDRATE;HYOSCYAMINE SULFATE DIHYDRATE;HYOSCYAMINE SULPHATE;HYOSCYAMINE SULFATE;BENZENEACETIC ACID, ALPHA-(HYDROXYMETHYL)-, 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, [3(S)-ENDO]-, SULFATE (2:1), DIHYDRATE;HYOSCYAMINESULFATE,USP;HOSCYAMINE SULFATE USP

Chemical Property of Hyoscyamine sulfate

Chemical Property:

• Melting Point: 206° when dry
• PSA: 200.98000
• LogP: 4.03700
• Solubility.: Very soluble in water, sparingly soluble or soluble in ethanol (96 per cent).

Purity/Quality:

99.9% ^*data from raw suppliers

HyoscyamineSulfate >99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Anticholinergic. Hyoscyamine Sulfate Dihydrate is a derivative of (-)-Hycosamine(H674300) is a natural compound that has inhibitory activity against cholinesterases.

Technology Process of Hyoscyamine sulfate

There total 5 articles about Hyoscyamine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Atropine (51-55-8) → atropine sulphate monohydrate (5908-99-6,5979-02-2,6835-16-1,73791-47-6)

Guidance literature:

Atropine; In ethanol; at 75 ℃; Reflux; Large scale;

With sulfuric acid; In ethanol; at 25 ℃; for 0.5h; Large scale;

Reference yield:

methyl 2-formyl-2-phenylacetate (5894-79-1) → atropine sulphate monohydrate (5908-99-6,5979-02-2,6835-16-1,73791-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 3 h / 110 °C / Large scale

2.1: palladium on activated charcoal; acetic acid / methanol; chloroform / 8 h / 12 - 15 °C / Large scale

3.1: ethanol / 75 °C / Reflux; Large scale

3.2: 0.5 h / 25 °C / Large scale

With palladium on activated charcoal; acetic acid; In methanol; ethanol; chloroform; toluene;

Reference yield:

3-tropanol (120-29-6) → atropine sulphate monohydrate (5908-99-6,5979-02-2,6835-16-1,73791-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 3 h / 110 °C / Large scale

2.1: palladium on activated charcoal; acetic acid / methanol; chloroform / 8 h / 12 - 15 °C / Large scale

3.1: ethanol / 75 °C / Reflux; Large scale

3.2: 0.5 h / 25 °C / Large scale

With palladium on activated charcoal; acetic acid; In methanol; ethanol; chloroform; toluene;

upstream raw materials:

(1R,3r,5S)-3-tropoyloxytropanium sulfate

methyl 2-formyl-2-phenylacetate

Atropine

3-tropanol

Downstream raw materials:

Tropic acid

(1R,3r,5S)-3-tropoyloxytropanium sulfate

apoatropine

Refernces

• 1、 Li, Meng,Zhang, Bo,Yu, Jia,Wang, Jian,Guo, Xingjie. "Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC". . p. 11724 - 11731. Retrieved 2018/07/25.