699-10-5

Basic information

• Product Name: BENZYL METHYL DISULFIDE
• Synonyms: BENZYL METHYL DISULFIDE;[(Methyldisulfanyl)methyl]benzene;Disulfide, benzyl methyl;Disulfide, methyl phenylmethyl;disulfide,benzylmethyl;Disulfide,methylphenylmethyl;Methyl benzyl disulfide;methylbenzyldisulfide
• CAS NO: 699-10-5
• Molecular Formula: C₈H₁₀S₂
• Molecular Weight: 170.29
• EINECS: 211-826-8
• Product Categories: sulfide Flavor
• Mol File: 699-10-5.mol

Chemical Properties

• Boiling Point: 259.97°C (rough estimate)
• Flash Point: 140.9oC
• Appearance: /
• Density: 1.1604 (rough estimate)
• Vapor Pressure: 0.00847mmHg at 25°C
• Refractive Index: 1.6210 (estimate)
• CAS DataBase Reference: BENZYL METHYL DISULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL METHYL DISULFIDE(699-10-5)
• EPA Substance Registry System: BENZYL METHYL DISULFIDE(699-10-5)

Safety Data

• Hazardous Substances Data: 699-10-5(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
BENZYL METHYL DISULFIDE is used as a flavoring agent for its characteristic sulfureous, vegetative, and metallic taste with an onion nuance. It is particularly suitable for enhancing the flavor of savory and green notes in various food products.
Used in Aromatherapy:
BENZYL METHYL DISULFIDE is used as an aromatic compound in aromatherapy for its cabbage-like, vegetative, and green metallic scent. It can be used in diffusers or blended with other essential oils to create unique and invigorating fragrances that promote relaxation and well-being.
Used in Cosmetics and Personal Care Products:
BENZYL METHYL DISULFIDE can be used as a fragrance ingredient in cosmetics and personal care products, such as perfumes, colognes, and body lotions, to provide a distinct and long-lasting scent.
Used in Food and Beverage Industry:
BENZYL METHYL DISULFIDE is used as a flavor enhancer in the food and beverage industry, particularly in products that require a sulfureous, vegetative, and metallic taste, such as certain types of sauces, soups, and beverages.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, BENZYL METHYL DISULFIDE may also have potential applications in the pharmaceutical industry as a starting material for the synthesis of various drugs or as an intermediate in the production of other organic compounds with therapeutic properties.

InChI:InChI=1/C8H10S2/c1-9-10-7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

Upstream product

• 19911-87-6 tetraethylammonium dithiobenzoate 
• 150-60-7 dibenzyl disulphide 
• 20828-73-3 methylsulfanylium 
• 624-92-0 Dimethyldisulphide 
• 100-53-8 phenylmethanethiol 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 20277-69-4 sodium methansulfinate 
• 100-44-7 benzyl chloride 
• 6313-36-6 benzyl thiosulphate 
• 110-81-6 Diethyl disulfide 
• 2179-57-9 diallyl disulphide 
• 629-19-6 Dipropyl disulfide 
• 57450-45-0 Benzyl-sulfonium 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 100-41-4 ethylbenzene 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 108-88-3 toluene 

Relevant articles and documents

The S2 oxygen atoms are essential for the pronounced fungitoxicity of the sulfur-rich natural product, dysoxysulfone

Synthesis and antifungal testing of 2,4,5,7,9-pentathiadecane 9,9-dioxide has established that the absence of oxygen atoms on S2 significantly attenuates fungitoxicity in accord with our earlier proposal. Attempts to convert that compound into dysoxysulfone led to the discovery of a novel oxidative conversion of unsymmetrical γ-sulfonyl disulfides into the corresponding symmetrical γ-sulfonyl disulfides. CSIRO 2005.

NFSI-catalyzed S[sbnd]S bond exchange reaction for the synthesis of unsymmetrical disulfides

The metal-free S[sbnd]S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is described. This novel protocol provides a facile and efficient approach to accessing important unsymmetrical disulfides. Furthermore, this strategy could also be utilized in the late-stage functionalization of amino acids, drugs, and natural products. The broad substrate scope, good functional group tolerance and easy accessibility of catalyst indicate that this strategy affords a green and practical complementary method to various unsymmetrical disulfides.

PdCl2/DMSO-Catalyzed Thiol-Disulfide Exchange: Synthesis of Unsymmetrical Disulfide

Unsymmetrical disulfides have been effectively prepared through thiol exchange with symmetrical disulfides employing a simple PdCl2/DMSO catalytic system. The given method features excellent functional group tolerance, a broad substrate scope, and operational simplicity. This reaction is especially useful for late-stage functionalization of bioactive scaffolds such as peptides and pharmaceuticals. Disulfide-containing organic dyes have also been prepared. This transformation could be extended to thiol-diselenide or thiol-ditelluride exchange affording RS-SeR′ or RS-TeR′.

Convenient Unsymmetrical Disulfane Synthesis: Basic Zeolite-Catalyzed Thiol-Disulfane Exchange Reaction

Convenient catalytic synthetic methods for the preparation of unsymmetrical disulfanes are described. Na-exchanged X type zeolite (Na-X), commercially available as MS-13X, effectively catalyzes thiol-disulfane exchange reactions with 1.0 equivalent of thi

An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species

A strategy to deliver a well-defined persulfide species in a biological medium is described. Under near physiological conditions, the persulfide prodrug can be activated by an esterase to generate a “hydroxymethyl persulfide” intermediate, which rapidly collapses to form a defined persulfide. Such persulfide prodrugs can be used either as chemical tools to study persulfide chemistry and biology or for future development as H2S-based therapeutic reagents. Using the persulfide prodrugs developed in this study, the reactivity between S-methyl methanethiosulfonate (MMTS) with persulfide was unambiguously demonstrated. Furthermore, a representative prodrug exhibited potent cardioprotective effects in a murine model of myocardial ischemia-reperfusion (MI/R) injury with a bell shape therapeutic profile.

Aryl-aryl, aryl-alkyl, alkyl-alkyl asymmetric the sulfur compounds and its synthetic method

The invention discloses a synthesis method of aryl-aryl, aryl-alkyl and alkyl-alkyl asymmetric persulfides as shown in a formula (II) or a formula (IV). According to the synthesis method, with sulfinic acid sodium salt, and halogenated hydrocarbon and Na2S2O3 as reaction materials or Bunte salt as a reaction material instead of the halogenated hydrocarbon and Na2S2O3, the aryl-aryl, aryl-alkyl and alkyl-alkyl asymmetric persulfides are obtained by reaction in the absence of transition metal. The synthesis method has the advantages that the reaction is efficient; the yield is high; a vulcanizing reagent is cheap, easily available, stable, and free of pungent smell; no strong acid or alkali or extra oxidizing or reducing agent is added in reaction; the condition is relatively mild; and no transition metal is used as a catalyst in the reaction, and therefore the method is economical, practical and friendly to the environment; a reaction substrate is easy to prepare; the reaction efficiency is high after the reaction is amplified, and therefore, the synthesis method has a wide application prospect and practical value.

Transition-metal-free persulfuration to construct unsymmetrical disulfides and mechanistic study of the sulfur redox process

A sulfur redox process has been developed between sulfinate and thiosulfate, which efficiently affords diverse unsymmetrical disulfides and provides a new method to modify pharmaceuticals and natural products without requiring an extra oxidant or reductant. Gram-scale investigation further demonstrates the practicality and application potential of this process. Isolated key intermediates and a series of control experiments afford an unusual process, which reveals the mechanism of comproportionation and the transition-metal-free sulfur redox process.

Phosphine-catalyzed disulfide metathesis

The reaction between disulfides and phosphines generates a reversible disulfide metathesis process. The Royal Society of Chemistry 2008.

Cleavage of S-S bond by nitric oxide (NO) in the presence of oxygen: A disproportionation reaction of two disulfides

Disulfide bond was cleaved by a catalytic amount of nitric oxide in the presence of oxygen, which was confirmed by experiments employing two symmetrical disulfides. The reaction resulted in the formation of unsymmetrical disulfides in nearly 50% yields. The steric hindrance of alkyl disulfide slowed the reaction rate, and an electron-donating group on the aryl disulfide promoted the reaction. The substituent and S-nitrosothiol effects suggested that the reaction was initialized with an oxidative process by NO+.

Disproportionation reaction of disulfides promoted by nitric oxide (NO) in the presence of oxygen

Two disulfides brought about disproportionation reaction to afford an unsymmetrical disulfide in 50% yield with a catalytic amount of nitric oxide in the presence of oxygen. The reaction proceeded faster when alkyl disulfides were employed for the reaction, and the substituent effects suggested that the reaction commenced with an oxidative process.