7306-46-9Relevant articles and documents
Kinetics and Mechanism of the Hydrolysis of Benzyl Ether Bonds in Aqueous–Organic Media
Kushner, M. A.,Matusevich, L. G.,Seliverstova, T. S.
, p. 310 - 316 (2020/04/10)
Abstract: Kinetic parameters (rate constant, energy of activation, and entropy of activation) of the acid-catalyzed hydrolysis of the benzyl ethers (3,4-dimethoxyphenyl)-(2-methoxyphenoxy)methane and (4-hydroxy-3-methoxyphenyl)methoxymethane are determined for a wide range of compositions for mixtures of water and organic solvents (dioxane, DMSO, and acetic acid). It is shown that the acid-catalyzed hydrolysis of these benzyl ethers in mixtures of water and aprotic solvents occurs as a reaction of bimolecular nucleophilic substitution. In aqueous acetic acid solutions, the mechanism of hydrolysis can be bimolecular or unimolecular, depending on the structure of the ether and the content of the organic solvent. The effect the solvents have on the rate and mechanism of the studied reaction is discussed in terms of solvation concepts.
Triazole derivative as well as preparation method and application thereof
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, (2020/06/09)
The invention relates to a triazole derivative as well as a preparation method and application thereof, which belong to the technical field of organic synthetic drugs. The structure of the triazole derivative is shown as a formula I. In the formula I, R1 and R2 are H, Cl, Br,-CF3,-CH(CH3)2 or -OCH3, and R1 and R2 are not H at the same time. R3 is -CH2 or -COCH2; X and Y are N or C, X and Y are not C at the same time, and X and Y are not N at the same time. The triazole derivative disclosed by the invention has a certain inhibition effect on germs of various crop diseases. Small toxic andside effects on plants are achieved. The preparation method of the triazole derivative is simple.
In vitro study and structure-activity relationship analysis of stilbenoid derivatives as powerful vasorelaxants: Discovery of new lead compound
Chan, Sock Ying,Loh, Yean Chun,Oo, Chuan Wei,Yam, Mun Fei
, (2020/10/12)
The development of vasorelaxant as the antihypertensive drug is important as it produces a rapid and direct relaxation effect on the blood vessel muscles. Resveratrol (RV), as the most widely studied stilbenoid and the lead compound, inducing the excellent vasorelaxation effect through the multiple signalling pathways. In this study, the in vitro vascular response of the synthesized trans-stilbenoid derivatives, SB 1-8e were primarily evaluated by employing the phenylephrine (PE)-precontracted endothelium-intact isolated aortic rings. Herein we report trans-3,4,4′-trihydroxystilbene (SB 8b) exhibited surprisingly more than 2-fold improvement to the maximal relaxation (Rmax) of RV. This article also highlights the characterization of the aromatic protons in terms of their unique splitting patterns in 1H NMR.
AN EFFICIENT AND ENVIRONMENT FRIENDLY PROCESS FOR CHLOROMETHYLATION OF SUBSTITUTED BENZENES
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Paragraph 0079; 0080, (2020/12/30)
Disclosed herein is an efficient, environment friendly and commercially viable process for preparation of chloromethylated compound of formula I in substantially pure form and high yield, from the compound of formula II. The process includes contacting the compound of formula II with a chloromethylating agent generated in-situ by reaction of a formaldehyde precursor and hydrogen chloride, in a suitable solvent/contacting medium and in the presence of a catalytic amount of a short chain/low molecular weight carboxylic acid of formula III. I II III wherein, R1, R2, R3 and R4 are as defined in the description.
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives
Guan, Li,Zhou, Junting,Lin, Qinghua,Zhu, Huilin,Liu, Wenyuan,Liu, Baolin,Zhang, Yanbo,Zhang, Jie,Gao, Jing,Feng, Feng,Qu, Wei
, p. 2657 - 2665 (2019/05/01)
Two series of moscatilin derivatives were designed, synthesized and evaluated as anti-tumor and anti-angiogenesis agents. Most of these compounds showed moderate-to-obvious cytotoxicity against five cancer cell lines (A549, HepG2, MDA-MB-231, MKN-45, HCT116). Among these cell lines, compounds had obvious effects on HCT116. Especially for 8Ae, the IC50 was low to 0.25 μM. 8Ae can inhibit the viability and induce the apoptosis of HCT116 cells but exhibit no cytotoxic activity in noncancerous NCM460 colon cells. 8Ae can also arrest the G2/M cell cycle in HCT116 cells by inhibiting the α-tubulin expression. Zebrafish bioassay-guided screen showed the 22 moscatilin derivatives had potent anti-angiogenic activities and compound 8Ae had better activities than positive compound. Molecular docking indicated 8Ae interacted with tubulin at the affinity of ?7.2 Kcal/mol. In conclusion, compound 8Ae was a potential antitumor and anti-angiogenesis candidate for further development.
DIHYDROQUINOLIZINONES AS ANTIVIRALS
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Paragraph 001628; 001630; 001631, (2018/09/19)
Compounds, specifically hepatitis B virus and/or hepatitis D virus inhibitors, more specifically compounds that inhibit HBe antigen and HBs antigen in a subject, for the treatment of viral infections, and methods of preparing and using such compounds. Formula (I):
AN EFFICIENT PROCESS FOR THE SYNTHESIS OF ALKOXY SUBSTITUTED BENZALDEHYDES
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Page/Page column 22, (2016/07/27)
The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxybenzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5- trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.
Production technology of 3,4-dimethoxy phenethylamine
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Paragraph 0005; 0019, (2016/10/08)
A production technology of 3,4-dimethoxyphenethylamine is disclosed, and characterized by using 3,4-dihydroxybenzyl chloride and dimethyl sulfate as raw materials; performing an etherification reaction to generate 3,4-dimethoxybenzyl chloride in the presence of sodium hydrate; performing an cyanation reaction on the 3,4-dimethoxybenzyl chloride and a cyanide compound to generate 3,4-dimethoxybenzyl cyanide; cooling the 3,4-dimethoxybenzyl cyanide in propanone for crystallization to obtain 3,4-dimethoxybenzyl cyanide crystals; subjecting 3,4-dimethoxybenzyl cyanide to catalytic ammoniation and hydrogenation in a solvent to generate 3,4-dimethoxyphenethylamine; and performing reduced-pressure distillation on the product obtained after ammoniation and hydrogenation to obtain an qualified product of 3,4-dimethoxyphenethylamine. The overall product yield is 86% or higher.
3,4,2′-Trimethoxy-trans-stilbene-a potent CYP1B1 inhibitor
Mikstacka, Renata,Wierzchowski, Marcin,Dutkiewicz, Zbigniew,Gielara-Korzańska, Agnieszka,Korzański, Artur,Teubert, Anna,Sobiak, Stanis?aw,Baer-Dubowska, Wanda
supporting information, p. 496 - 501 (2014/04/17)
A novel series of methoxy-trans-stilbenes with 3,4-dimethoxy motifs was designed and synthesized. The inhibitory potency of 3,4-dimethoxystilbene derivatives against cytochrome P450 isozymes CYP1A1, CYP1B1 and CYP1A2 was evaluated. 3,4,2′-Trimethoxy-trans-stilbene (3,4,2′-TMS) exhibited extremely potent inhibitory action against CYP1B1 activity with an IC 50 of 0.004 μM. 3,4,2′-TMS exhibited 90-fold selectivity for CYP1B1 over CYP1A1 and 830-fold selectivity for CYP1B1 over CYP1A2. However, 3,4,2′,4′-tetramethoxy-trans-stilbene appeared to be the most selective inhibitor of both CYP1B1 and CYP1A1 showing very low affinity toward CYP1A2. Complementary experimental studies and computational methods were used to explain what structural determinants decide the specific affinity of stilbene derivatives to CYP1A2 and CYP1B1 binding sites.
A heterogeneous layered bifunctional catalyst for the integration of aerobic oxidation and asymmetric C-C bond formation
Miyamura, Hiroyuki,Choo, Gerald C. Y.,Yasukawa, Tomohiro,Yoo, Woo-Jin,Kobayashi, Shu
supporting information, p. 9917 - 9919 (2013/10/22)
The design and synthesis of a heterogeneous bifunctional chiral catalyst for the sequential aerobic oxidation-asymmetric Michael reactions between primary allylic alcohols and dibenzyl malonate are described. Interestingly, we found that layering bimetallic nanoparticles over the organocatalyst, within the chiral composite material, is crucial for catalytic activity.
