73322-01-7

Basic information

• Product Name: 1-NITRO-4-(2-PYRIDYLTHIO)BENZENE
• Synonyms: 1-NITRO-4-(2-PYRIDYLTHIO)BENZENE
• CAS NO: 73322-01-7
• Molecular Formula: C₁₁H₈N₂O₂S
• Molecular Weight: 232.26
• Product Categories: Pyridines
• Mol File: 73322-01-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-NITRO-4-(2-PYRIDYLTHIO)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-NITRO-4-(2-PYRIDYLTHIO)BENZENE(73322-01-7)
• EPA Substance Registry System: 1-NITRO-4-(2-PYRIDYLTHIO)BENZENE(73322-01-7)

Safety Data

• Hazardous Substances Data: 73322-01-7(Hazardous Substances Data)

Usage

1-Nitro-4-(2-Pyridylthio)benzene Properties

A compound consisting of 11 carbon atoms, 8 hydrogen atoms, 2 nitrogen atoms, 2 oxygen atoms, and 1 sulfur atom.
2. Nitrobenzene derivative
A compound derived from nitrobenzene by modifying its structure, in this case, by attaching a pyridylthio group at the 4-position.
3. Pyridylthio group attachment at the 4-position
A pyridylthio group (a pyridine ring with a sulfur atom attached) is connected to the benzene ring at the 4th carbon position.
4. Organic synthesis utility
The compound is commonly used in organic synthesis, serving as a building block for the preparation of various organic compounds.
5. Potential applications in pharmaceutical and agrochemical industries
Due to its ability to form diverse chemical bonds and structural motifs, the compound has potential uses in the development of pharmaceutical and agrochemical products.
6. Reagent and precursor uses
The compound can be used as a reagent in chemical reactions and as a precursor for the synthesis of various functional materials.
7. Health and environmental hazards
1-Nitro-4-(2-Pyridylthio)benzene may pose health and environmental risks, so it should be handled with care and proper safety precautions.

Upstream product

• 2637-34-5 2-Sulfanylpyridine 
• 350-46-9 4-Fluoronitrobenzene 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 905718-45-8 [(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] 
• 5029-67-4 2-iodopyridine 
• 1849-36-1 para-nitrobenzenethiol 
• 2937-05-5 4-nitrobenzenesulfonohydrazide 
• 197958-29-5 pyridin-2-ylboronic acid 
• 109-04-6 2-bromo-pyridine 
• 100-00-5 4-chlorobenzonitrile 
• 79236-86-5 2-mercaptopyridine potassium salt 
• 107264-09-5 1-fluoro-pyridinium tetrafluoroborate 

Downstream Products

• 1279130-14-1 4-nitrophenyl 2-pyridyl sulfoxide 
• 147696-59-1 4-(pyridine-2-sulfonyl)-aniline 
• 497850-82-5 7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-{4-[(2-pyridyl)sulfanyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 91933-69-6 (4-nitro-phenyl)-[2]pyridyl disulfide 
• 69770-62-3 2-(4-nitrobenzenesulfonyl)-pyridine 
• 70991-08-1 4-(pyridine-2-ylthio)-aniline 

Relevant articles and documents

Dimsyl Anion Enables Visible-Light-Promoted Charge Transfer in Cross-Coupling Reactions of Aryl Halides

A methodology is reported for visible-light-promoted synthesis of unsymmetrical chalcogenides enabled by dimsyl anion in the absence of transition-metals or photoredox catalysts. The cross-coupling reaction between aryl halides and diaryl dichalcogenides proceeds with electron-rich, electron-poor, and heteroaromatic moieties. Mechanistic investigations using UV-Vis spectroscopy, time-dependent density functional theory (TD-DFT) calculations, and control reactions suggest that dimsyl anion forms an electron-donor-acceptor (EDA) complex capable of absorbing blue light, leading to a charge transfer responsible for generation of aryl radicals from aryl halides. This previously unreported mechanistic pathway may be applied to other light-induced transformations performed in DMSO in the presence of bases and aryl halides.

Transition metal-free, chemoselective arylation of thioamides yielding aryl thioimidates or N-aryl thioamides

Reactions of secondary thioamides with diaryliodonium salts under basic, transition metal-free conditions resulted in chemoselective S-arylation to provide aryl thioimidates in good to excellent yields. Equimolar amounts of thioamide, base and diaryliodonium salt were sufficient to obtain a diverse selection of products within short reaction times. Reactions with thiolactams delivered N-arylated thioamides in good yield at room temperature.

Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: An electrophile-nucleophile dual activation by [Omim]Br for the reaction

A facile aromatic nucleophilic substitution (SNAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, 1H NMR and IR spectroscopies. This chemistry provides an efficient and metal-free approach for the generation of Caryl-X (XS, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodology attractive to both synthetic and medicinal chemistry.