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73724-45-5

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73724-45-5 Usage

Chemical Properties

Light yellow powder

Uses

N-Fmoc-L-serine is an N-Fmoc-protected form of L-Serine (S270975). L-Serine is a nonessential amino acid that is required for the synthesis of sphingolipids and phosphatidylserine, compounds that are important for central nervous system neuronal survival. L-Serine is also important in intermediary metabolism in eukaryotic cells.

Check Digit Verification of cas no

The CAS Registry Mumber 73724-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,7,2 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 73724-45:
(7*7)+(6*3)+(5*7)+(4*2)+(3*4)+(2*4)+(1*5)=135
135 % 10 = 5
So 73724-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H17NO5/c20-9-16(17(21)22)19-18(23)24-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16,20H,9-10H2,(H,19,23)(H,21,22)/p-1/t16-/m0/s1

73724-45-5 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (F0454)  N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine Hydrate  >97.0%(HPLC)(T)

  • 73724-45-5

  • 1g

  • 450.00CNY

  • Detail
  • TCI America

  • (F0454)  N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine Hydrate  >97.0%(HPLC)(T)

  • 73724-45-5

  • 5g

  • 990.00CNY

  • Detail
  • Alfa Aesar

  • (B21079)  N-Fmoc-L-serine, 97+%   

  • 73724-45-5

  • 1g

  • 689.0CNY

  • Detail
  • Alfa Aesar

  • (B21079)  N-Fmoc-L-serine, 97+%   

  • 73724-45-5

  • 5g

  • 2302.0CNY

  • Detail
  • Aldrich

  • (47601)  Fmoc-Ser-OH  ≥97.0% (sum of enantiomers, HPLC)

  • 73724-45-5

  • 47601-5G-F

  • 1,026.09CNY

  • Detail

73724-45-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Fmoc-L-Serine

1.2 Other means of identification

Product number -
Other names Fmoc-L-Ser-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73724-45-5 SDS

73724-45-5Relevant articles and documents

Tetrahydropyranyl: A Non-aromatic, Mild-Acid-Labile Group for Hydroxyl Protection in Solid-Phase Peptide Synthesis

Sharma, Anamika,Ramos-Tomillero, Iván,El-Faham, Ayman,Rodríguez, Hortensia,de la Torre, Beatriz G.,Albericio, Fernando

, p. 206 - 210 (2017)

The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side-chain hydroxyl groups in solid-phase peptide synthesis has not been widely investigated. Ser/Thr side-chain hydroxyl protection with this acid-labile and non-aromatic moiety is presented here. Although Thp reacts with free carboxylic acids, it can be concluded that to introduce Thp ethers at the hydroxyl groups of N-protected Ser and Thr, protection of the C-terminal carboxyl group is unnecessary due to the lability of Thp esters. Thp-protected Ser/Thr-containing tripeptides are synthesized and the removal of Thp studied in low concentrations of trifluoroacetic acid in the presence of cation scavengers. Given its general stability to most non-acidic reagents, improved solubility of its conjugates and ease with which it can be removed, Thp emerges as an effective protecting group for the hydroxyl groups of Ser and Thr in solid-phase peptide synthesis.

Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues

Sasaki, Mio,Kadowaki, Toma,Kato, Seiya,Chida, So,Yano, Shigekazu,Nosaka, Kazuto,Konno, Hiroyuki

supporting information, (2021/11/27)

The synthesis of xylose-bearing cyclic octalipopeptides burkholdine-1213 analogues is described. Sugar-containing lipopeptides are generally highly amphiphilic and often exhibit potent antifungal activities, but a synthesis of a xylose-bearing burkholdine analogue has never been reported. We prepared burkholdine-1213 analogues by solution-phase macrolactamization of xylose-bearing linear peptides obtained by incorporating the bespoke Fmoc-Ser(β-O-xyloseAc3)-OH building block into a Fmoc-solid phase peptide synthesis protocol. All analogues synthesized exhibited similar properties and moderate antifungal activities.

Novel chiral stationary phases based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin combining cinchona alkaloid moiety

Zhu, Lunan,Zhu, Junchen,Sun, Xiaotong,Wu, Yaling,Wang, Huiying,Cheng, Lingping,Shen, Jiawei,Ke, Yanxiong

, p. 1080 - 1090 (2020/05/25)

Novel chiral selectors based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin connecting quinine (QN) or quinidine (QD) moiety were synthesized and immobilized on silica gel. Their chromatographic performances were investigated by comparing to the 3,5-dimethyl phenylcarbamoylated β-cyclodextrin (β-CD) chiral stationary phase (CSP) and 9-O-(tert-butylcarbamoyl)-QN-based CSP (QN-AX). Fmoc-protected amino acids, chiral drug cloprostenol (which has been successfully employed in veterinary medicine), and neutral chiral analytes were evaluated on CSPs, and the results showed that the novel CSPs characterized as both enantioseparation capabilities of CD-based CSP and QN/QD-based CSPs have broader application range than β-CD-based CSP or QN/QD-based CSPs. It was found that QN/QD moieties play a dominant role in the overall enantioseparation process of Fmoc-amino acids accompanied by the synergistic effect of β-CD moiety, which lead to the different enantioseparation of β-CD-QN-based CSP and β-CD-QD-based CSP. Furthermore, new CSPs retain extraordinary enantioseparation of cyclodextrin-based CSP for some neutral analytes on normal phase and even exhibit better enantioseparation than the corresponding β-CD-based CSP for certain samples.

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