7481-64-3Relevant articles and documents
Confirmation of the absolute (3R,3′S,6′R)-configuration of (all-E)-3′-epilutein
Molnar, Peter,Deli, Jozsef,Osz, Erzsebet,Zsila, Ferenc,Simonyi, Miklos,Toth, Gyula
, p. 2159 - 2168 (2004)
Circular dichroism (CD) spectroscopy was used to distinguish between the isomeric (all-E)-configured 3′-epilutein (2) and 6′-epilutein (8) to establish the absolute configuration of epilutein samples of different (natural and semisynthetic) origin, including samples of 2 obtained from thermally processed sorrel. Thus, the CD data of lutein (1) and epilutein samples (2) were compared. Our results unambiguously confirmed the (3R,3′S,6′R)- configuration of all epilutein samples. Compound 2 was thoroughly characterized, and its 13C-NMR data are published herewith for the first time.
Combination of carotenoids and epi-lutein
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Page/Page column 18, (2018/01/20)
The invention describes the preparation and use of carotenoid and epi-lutein compositions to treat various ocular diseases.
Process for Synthesis of (3R,3'R,6'R)-Lutein and its Stereoisomers
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Page/Page column 10-11; 25, (2009/10/30)
(3R,3′R,6′R)-Lutein and (3R,3′R)-zeaxanthin are two dietary carotenoids that are present in most fruits and vegetables commonly consumed in the US. These carotenoids accumulate in the human plasma, major organs, and ocular tissues. In the past decade, numerous epidemiological and experimental studies have shown that lutein and zeaxanthin play an important role in the prevention of age-related macular degeneration (AMD) that is the leading cause of blindness in the U.S. and Western World. The invention provides a process for the synthesis of (3R,3′R,6′R)-lutein and its stereoisomers from commercially available (rac)-α-ionone by a C15+C10+C15 coupling strategy. In addition, the present invention also provides access to the precursors of optically active carotenoids with 3-hydroxy-ε-end group that are otherwise difficult to synthesize. The process developed for the synthesis of lutein and its stereoisomers is straightforward and has potential for commercialization.