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Cas Database

75665-73-5

75665-73-5

Identification

  • Product Name:Ethanone, 1-[2-amino-5-methoxy-4-(phenylmethoxy)phenyl]-

  • CAS Number: 75665-73-5

  • EINECS:

  • Molecular Weight:271.316

  • Molecular Formula: C16H17NO3

  • HS Code:2922509090

  • Mol File:75665-73-5.mol

Synonyms:1-[2-AMINO-5-METHOXY-4-(PHENYLMETHOXY)PHENYL]ETHANONE

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:Crysdot
  • Product Description:1-(2-Amino-4-(benzyloxy)-5-methoxyphenyl)ethanone 97%
  • Packaging:5g
  • Price:$ 831
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:Ethanone,1-[2-amino-5-methoxy-4-(phenylmethoxy)phenyl]-
  • Packaging:250mg
  • Price:$ 124
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  • Manufacture/Brand:Chemenu
  • Product Description:1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethan-1-one 95+%
  • Packaging:5g
  • Price:$ 777
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:1-(2-Amino-4-benzyloxy-5-methoxy-phenyl)-ethanone 95%
  • Packaging:5 G
  • Price:$ 1125
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-(2-AMINO-4-(BENZYLOXY)-5-METHOXYPHENYL)ETHANONE 95.00%
  • Packaging:5MG
  • Price:$ 502.61
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  • Manufacture/Brand:Alichem
  • Product Description:1-(2-Amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
  • Packaging:25g
  • Price:$ 2889.12
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  • Manufacture/Brand:Alichem
  • Product Description:1-(2-Amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
  • Packaging:10g
  • Price:$ 1556
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  • Manufacture/Brand:Alichem
  • Product Description:1-(2-Amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
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  • Manufacture/Brand:Abosyn
  • Product Description:1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone 95%-98%
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Relevant articles and documentsAll total 15 Articles be found

Heterocyclic compound, preparation method and application thereof

-

, (2020/07/02)

The invention relates to a heterocyclic compound in the technical field of medicines. The compound is represented by a structural general formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, X, Y, Z, Cy1, Cy2, m, n and t have the meanings given in the specification; in addition, the invention also discloses an application of the compound and the pharmaceuticallyacceptable salt thereof in preparation of drugs for treating diseases caused by abnormal high expression of tyrosine kinase, especially application in preparation of drugs for treating and preventingcancers.

CARBAMATE AND UREA COMPOUNDS AS MULTIKINASE INHIBITORS

-

, (2019/07/13)

The present disclosure describes carbamate and urea compounds as novel multikinase inhibitors and methods for preparing them. The pharmaceutical compositions comprising such multikinase inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders associated with kinases are also described.

A alkyne generation quinoline derivatives and its preparation and use

-

, (2017/08/25)

The invention discloses alkynylquinoline derivatives, and a preparation method and application thereof. The acetylenoquinoline derivatives are alkynylquinoline compounds as shown in a general formula I which is described in the specification and pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof. The invention also provides the preparation method for the derivatives and relates to inhibition activity of the compounds as shown in the formula I to a variety of protein tyrosine kinases (e.g. C-Met and VEGFR). Thus, the compounds can be used as anticancer drugs for treatment of human cancers.

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors

Yang, Hao,Murigi, Francis N.,Wang, Zhijian,Li, Junfeng,Jin, Hongjun,Tu, Zhude

, p. 919 - 924 (2015/02/19)

Fifteen cinnoline analogues and six benzimidazole phosphodiesterase 10A (PDE10A) inhibitors were synthesized as potential PET radiopharmaceuticals and their in vitro activity as PDE10A inhibitors was determined. Nine out of twenty-one compounds were potent inhibitors of PDE10A with IC50 values ranging from 1.5 to 18.6 nM. Notably, the IC50 values of compounds 26a, 26b, and 33c were 1.52 ± 0.18, 2.86 ± 0.10, and 3.73 ± 0.60 nM, respectively; these three compounds also showed high in vitro selectivity (>1000-fold) for PDE10A over PDE 3A/3B, PDE4A/4B. The high potency and selectivity of these three compounds suggests that they could be radiolabeled with PET radionuclides for further evaluation of their in vivo pharmacological behavior and ability to quantify PDE10A in the brain.

THERAPEUTIC COMPOUNDS AND USES THEREOF

-

, (2014/09/03)

Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.

Process route upstream and downstream products

Process route

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone
75665-88-2

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
With ammonium acetate; iron; In water; toluene; at 105 ℃;
100%
With ammonium formate; iron; In water; toluene; at 103 ℃;
99%
With ammonium acetate; iron; In water; toluene; Product distribution / selectivity; Heating / reflux;
90%
With ammonium formate; iron; In water; toluene; Product distribution / selectivity; Heating / reflux;
90%
With ammonium acetate; iron; In water; toluene; Heating / reflux;
90%
With ammonium formate; iron; In water; toluene; Heating / reflux;
90%
With water; ammonium formate; iron; In toluene; for 48h; Heating / reflux;
86%
With ammonium chloride; zinc; In ethanol; water; for 5h; Reflux;
86%
With ammonium formate; iron; In water; toluene; Reflux;
79%
With tin(II) chloride dihdyrate; In ethanol; for 2h; Reflux;
72.2%
With tin(II) chloride dihdyrate; In ethanol; at 25 ℃; for 2h; Reflux;
72.2%
With ammonium acetate; iron; In water; toluene; at 88 ℃; for 18h;
54.5 g
With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 2h; Inert atmosphere;
With iron; acetic acid; In ethanol; water; for 3h; Reflux;
174.7 g
benzyl bromide
100-39-0

benzyl bromide

1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
With sodium hydroxide; ammonium chloride; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
77%
4-benzyloxy-3-methoxyacetophenone
1835-11-6

4-benzyloxy-3-methoxyacetophenone

benzyl bromide
100-39-0

benzyl bromide

1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone
75665-88-2

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
With iron; potassium carbonate; In dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether;
70%
4-benzyloxy-3-methoxyacetophenone
1835-11-6

4-benzyloxy-3-methoxyacetophenone

benzyl bromide
100-39-0

benzyl bromide

tin(IV) chloride
7646-78-8

tin(IV) chloride

1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone
75665-88-2

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
With nitric acid; iron; potassium carbonate; In dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether;
70%
benzyl bromide
100-39-0

benzyl bromide

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / acetonitrile / 24 h / Reflux; Inert atmosphere
2: nitric acid / acetic acid
3: tin(II) chloride dihdyrate / ethanol / 2 h / 25 °C / Reflux
With tin(II) chloride dihdyrate; nitric acid; potassium carbonate; potassium iodide; In ethanol; acetic acid; acetonitrile;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C
2: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8
3: ammonium formate; iron / toluene; water / 103 °C
With sulfuric acid; nitric acid; ammonium formate; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C
3: iron; ammonium acetate / toluene; water / 105 °C
With sulfuric acid; ammonium acetate; nitric acid; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / acetonitrile / 12 h / 80 °C
2: acetic acid; nitric acid / 14 h / 0 - 20 °C
3: ammonium acetate; iron / toluene; water / 18 h / 88 °C
With ammonium acetate; nitric acid; iron; potassium carbonate; acetic acid; potassium iodide; In water; toluene; acetonitrile;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: sulfuric acid; nitric acid / dichloromethane; water / 1.33 h / 0 °C
3: ammonium formate; iron / water; toluene / Heating / reflux
With sulfuric acid; nitric acid; ammonium formate; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux
2: nitric acid; acetic acid / 18 h / 10 - 20 °C
3: ammonium chloride; zinc / ethanol; water / 5 h / Reflux
With nitric acid; potassium carbonate; ammonium chloride; acetic acid; zinc; potassium iodide; In ethanol; water; acetone;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: sulfuric acid; nitric acid / dichloromethane / 1.33 h / 0 °C
3: ammonium formate; iron / water; toluene / Heating / reflux
With sulfuric acid; nitric acid; ammonium formate; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 40 °C / Inert atmosphere
2: sulfuric acid; nitric acid / dichloromethane / 0 °C
3: iron; ammonium chloride / ethanol; water / 2 h / 90 °C / Inert atmosphere
With sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 4 h / 20 °C
2.1: nitric acid / dichloromethane / 4 h / -20 - -10 °C
3.1: iron; acetic acid / ethanol; water / 3 h / Reflux
With nitric acid; iron; potassium carbonate; acetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / acetonitrile / 24 h / Reflux; Inert atmosphere
2: nitric acid / acetic acid
3: tin(II) chloride dihdyrate / ethanol / 2 h / 25 °C / Reflux
With tin(II) chloride dihdyrate; nitric acid; potassium carbonate; potassium iodide; In ethanol; acetic acid; acetonitrile;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C
2: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8
3: ammonium formate; iron / toluene; water / 103 °C
With sulfuric acid; nitric acid; ammonium formate; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C
3: iron; ammonium acetate / toluene; water / 105 °C
With sulfuric acid; ammonium acetate; nitric acid; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / acetonitrile / 12 h / 80 °C
2: acetic acid; nitric acid / 14 h / 0 - 20 °C
3: ammonium acetate; iron / toluene; water / 18 h / 88 °C
With ammonium acetate; nitric acid; iron; potassium carbonate; acetic acid; potassium iodide; In water; toluene; acetonitrile;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: sulfuric acid; nitric acid / dichloromethane; water / 1.33 h / 0 °C
3: ammonium formate; iron / water; toluene / Heating / reflux
With sulfuric acid; nitric acid; ammonium formate; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux
2: nitric acid; acetic acid / 18 h / 10 - 20 °C
3: ammonium chloride; zinc / ethanol; water / 5 h / Reflux
With nitric acid; potassium carbonate; ammonium chloride; acetic acid; zinc; potassium iodide; In ethanol; water; acetone;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: sulfuric acid; nitric acid / dichloromethane / 1.33 h / 0 °C
3: ammonium formate; iron / water; toluene / Heating / reflux
With sulfuric acid; nitric acid; ammonium formate; iron; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 40 °C / Inert atmosphere
2: sulfuric acid; nitric acid / dichloromethane / 0 °C
3: iron; ammonium chloride / ethanol; water / 2 h / 90 °C / Inert atmosphere
With sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 4 h / 20 °C
2.1: nitric acid / dichloromethane / 4 h / -20 - -10 °C
3.1: iron; acetic acid / ethanol; water / 3 h / Reflux
With nitric acid; iron; potassium carbonate; acetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
4-benzyloxy-3-methoxyacetophenone
1835-11-6

4-benzyloxy-3-methoxyacetophenone

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: nitric acid / acetic acid
2: tin(II) chloride dihdyrate / ethanol / 2 h / 25 °C / Reflux
With tin(II) chloride dihdyrate; nitric acid; In ethanol; acetic acid;
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8
2: ammonium formate; iron / toluene; water / 103 °C
With sulfuric acid; nitric acid; ammonium formate; iron; In dichloromethane; water; toluene;
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C
2: iron; ammonium acetate / toluene; water / 105 °C
With sulfuric acid; ammonium acetate; nitric acid; iron; In dichloromethane; water; toluene;
Multi-step reaction with 2 steps
1: tin(IV) chloride; nitric acid / dichloromethane / -70 °C
2: iron; ammonium formate / toluene; water / Reflux
With nitric acid; ammonium formate; tin(IV) chloride; iron; In dichloromethane; water; toluene;
Multi-step reaction with 2 steps
1: acetic acid; nitric acid / 14 h / 0 - 20 °C
2: ammonium acetate; iron / toluene; water / 18 h / 88 °C
With ammonium acetate; nitric acid; iron; acetic acid; In water; toluene;
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / dichloromethane / 1.33 h / 0 °C
2: ammonium formate; iron / water; toluene / Heating / reflux
With sulfuric acid; nitric acid; ammonium formate; iron; In dichloromethane; water; toluene;
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / dichloromethane / 0 °C
2: iron; ammonium chloride / ethanol; water / 2 h / 90 °C / Inert atmosphere
With sulfuric acid; nitric acid; iron; ammonium chloride; In ethanol; dichloromethane; water;
Multi-step reaction with 2 steps
1: nitric acid / dichloromethane / 4 h / -20 - -10 °C
2: iron; acetic acid / ethanol; water / 3 h / Reflux
With nitric acid; iron; acetic acid; In ethanol; dichloromethane; water;
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

4-chloro-6-methoxy-7-hydroxyquinoline
205448-31-3

4-chloro-6-methoxy-7-hydroxyquinoline

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
1.2: Inert atmosphere
2.1: trichlorophosphate / 10 h / Reflux
3.1: methanesulfonic acid; trifluoroacetic acid / 3 h / Reflux
3.2: 2 h / pH 7
With methanesulfonic acid; sodium methylate; trifluoroacetic acid; trichlorophosphate; In 1,2-dimethoxyethane;
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C
1.2: 8 h
2.1: trichlorophosphate / toluene / 2 h / Reflux
With sodium methylate; trichlorophosphate; In Dimethyl ether; toluene;
Multi-step reaction with 2 steps
1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
1.2: Inert atmosphere
2.1: trichlorophosphate / 10 h / Reflux
With sodium methylate; trichlorophosphate; In 1,2-dimethoxyethane;
Multi-step reaction with 2 steps
1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h
1.2: 15 h / 20 °C
2.1: trichlorophosphate / 4.33 h / Cooling with ice; Reflux
With sodium methylate; trichlorophosphate; In 1,2-dimethoxyethane;
Multi-step reaction with 2 steps
1.1: sodium ethanolate / 1,2-dimethoxyethane / 0.5 h
2.1: trichlorophosphate / 2 h / Heating / reflux
2.2: 20 °C / pH 8
With sodium ethanolate; trichlorophosphate; In 1,2-dimethoxyethane;
Multi-step reaction with 2 steps
1.1: sodium methylate / 1,2-dimethoxyethane / 1 h / 0 °C
1.2: 0 - 20 °C
2.1: trichlorophosphate / 3 h / 110 °C
2.2: Cooling with ice
With sodium methylate; trichlorophosphate; In 1,2-dimethoxyethane;
Multi-step reaction with 2 steps
1: sodium methylate / 1,2-dimethoxyethane / 0.5 h
2: trichlorophosphate / 2 h / Heating / reflux
With sodium methylate; trichlorophosphate; In 1,2-dimethoxyethane;
Multi-step reaction with 2 steps
1: sodium methylate / 1,2-dimethoxyethane / 20 °C
2: trichlorophosphate / toluene / 2 h / 100 °C
With sodium methylate; trichlorophosphate; In 1,2-dimethoxyethane; toluene;
Multi-step reaction with 2 steps
1.1: sodium ethanolate / 1,2-dimethoxyethane / 0.5 h / 20 °C
1.2: 7 h / 20 °C
2.1: trichlorophosphate / 9 h / Reflux
With sodium ethanolate; trichlorophosphate; In 1,2-dimethoxyethane;
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

formic acid ethyl ester
109-94-4

formic acid ethyl ester

6-methoxy-7-benzyloxy-4(1H)-quinolinone
205448-29-9,849217-23-8

6-methoxy-7-benzyloxy-4(1H)-quinolinone

Conditions
Conditions Yield
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone; With sodium methylate; In 1,2-dimethoxyethane; at 0 ℃; for 1h;
formic acid ethyl ester; In 1,2-dimethoxyethane; at 0 - 20 ℃;
94%
With sulfuric acid; sodium methylate; In tetrahydrofuran; water;
66%
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone; With sodium methylate; In 1,2-dimethoxyethane; at 20 ℃; for 0.5h;
formic acid ethyl ester; In 1,2-dimethoxyethane; at 20 ℃; for 1.5h;
With hydrogenchloride; water; In 1,2-dimethoxyethane; for 0.333333h;
38%

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