855875-40-0Relevant articles and documents
METHOD FOR SYNTHESIS OF LOBARIC ACID AND ANALOG THEREOF
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Paragraph 0074; 0112-0115; ; 0147-0150, (2021/08/13)
The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.
METHODS FOR SYNTHESIS OF CANNABINOID COMPOUNDS
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, (2020/03/02)
The present invention provides simple synthetic routes for the preparation of cannabinoid compounds such as CBD, CBDV, THC, THCV, CBN, HU-308, CBG, CBC, and derivatives thereof, which are stereoselective and provide the desired cannabinoid compound in high yield.
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum
Kim, Tai Kyoung,Kim, Joung Eun,Youn, Ui Joung,Han, Se Jong,Kim, Il-Chan,Cho, Cheon-Gyu,Yim, Joung Han
, p. 1460 - 1467 (2018/06/29)
The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a pseudodepsidone structure, was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction, and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities.
Synthesis and antibacterial evaluation of anziaic acid and its analogues as topoisomerase i inhibitors
Lin, Hao,Annamalai, Thirunavukkarasu,Bansod, Priyanka,Tse-Dinh, Yuk-Ching,Sun, Dianqing
, p. 1613 - 1618 (2013/12/04)
Naturally occurring anziaic acid has very recently been reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and its structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.