860-22-0 Usage
Uses
Used in Medical Procedures:
Indigo Carmine is used as a marker dye during cystoscopy and ureteral catheterization. It is also used in endoscopic procedures, lymph node and vessel delineation, and for tumor localization. However, it is an unapproved drug without FDA approved labeling.
Used in Colorant Industry:
Indigo Carmine is used as a colorant for nylon, surgical sutures, foods, and ingested drugs. It is also used as a reagent for functional kidney tests, for detection of nitrates, chlorates, and in testing milk.
Used in Food Industry:
Indigo Carmine (FD&C Blue #2) is used as a colorant in the food industry. It has poor pH stability, light stability, and oxidation stability, but moderate stability to heat. It is the only food color that has good resistance to reducing agents but has very poor compatibility with food components. The major use is in pet food, but it is also used in candies, confections, and baked goods.
Used in Textile Industry:
5,5’Indigodisulfonic Acid Disodium Salt, a form of Indigo Carmine, is used as a dye for cationic cotton fabrics in the textile industry.
Preparation
3H-indol-3-one,2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro?with strong sulfuric acid or trace fuming sulfuric acid products.
Air & Water Reactions
Water soluble.
Reactivity Profile
Sensitive to light. Very sensitive to oxidizing agents. Color is readily discharged by nitric acid, chlorates, etc. Color of aqueous solutions fades on standing.
Fire Hazard
Flash point data for Acid Blue 74 is not available, but Acid Blue 74 is probably combustible.
Biochem/physiol Actions
Indigo Carmine (IC), commonly known as acid blue 74 or food blue 1 or FD and C blue 2 is a blue synthetic dye. It is used as a redox indicator in analytical chemistry and as a microscopic stain in biology. IC is also employed as a photometric detector. IC is a highly toxic indigoid dye and is associated with various health hazards such as irritation to the gastrointestinal tract leading to nausea, vomiting, and diarrhea and irritation in the respiratory tract leading to coughing and shortness of breath. IC exposure might also cause skin and eye irritations to humans. IC dye spray is used for the diagnosis of dysplasia in ulcerative colitis and is considered to be a simple, feasible, and safe method.
Standard
Light Fastness
Fading
Stain
ISO
1-2
Purification Methods
Its solubility in H2O is 1g/100mL at 25o. It has been purified by dissolving in H2O, filtering and adding EtOH to cause the salt to separate. Wash the solid with EtOH, Et2O and dry in vacuo. [V.rlander & Schubert Chem Ber 34 1860 1901, UV: Smit et al. Anal Chem 27 1159 1955, Preisler et al. J Am Chem Soc 81 1991 1959, Beilstein 25 IV 1975.]
References
American Society of Health-system Pharmacist.Journal of Environmental Protection, 2016, 7, 1693-1706
Check Digit Verification of cas no
The CAS Registry Mumber 860-22-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,6 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 860-22:
(5*8)+(4*6)+(3*0)+(2*2)+(1*2)=70
70 % 10 = 0
So 860-22-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2/b14-13+;;
860-22-0Relevant articles and documents
NOVEL PROCESS FOR THE PREPARATION OF INDIGOTINDISULFONATE SODIUM (INDIGO CARMINE)
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Page/Page column 10, (2018/07/29)
This invention relates to an improved method for the preparation of highly or substantially pure Indigotindisulfonate sodium (1). It further relates to the novel crystalline form I of Indigotindisulfonate sodium (1) and the process for its preparation.
AN IMPROVED PROCESS FOR THE PREPARATION OF INDIGO CARMINE
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Page/Page column 10, (2017/06/27)
The present invention relates to an improved process for preparation of Indigo carmine of Formula (I), in high purity more than 99.5%.
