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Cas Database

883-99-8

883-99-8

Identification

  • Product Name:Methyl 3-hydroxy-2-naphthoate

  • CAS Number: 883-99-8

  • EINECS:212-936-9

  • Molecular Weight:202.21

  • Molecular Formula: C12H10O3

  • HS Code:2918290000

  • Mol File:883-99-8.mol

Synonyms:2-Hydroxy-3-naphthoic acid methyl ester;2-Naphthalenecarboxylic acid, 3-hydroxy-, methyl ester;2-Naphthoic acid, 3-hydroxy-, methyl ester;2-Naphthoic acid, 3-hydroxy-, methyl ester (8CI);Methyl 3-hydroxy-2-naphthalenecarboxylate;Methyl 2-hydroxy-3-naphthoate;methyl 3-hydroxynaphthalene-2-carboxylate;

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Safety information and MSDS view more

  • Pictogram(s):

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:Methyl 3-Hydroxy-2-naphthoate
  • Packaging:2.5g
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Methyl 3-Hydroxy-2-naphthoate
  • Packaging:500mg
  • Price:$ 60
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Methyl 3-Hydroxy-2-naphthoate >99.0%(GC)
  • Packaging:25g
  • Price:$ 44
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Methyl 3-hydroxy-2-naphthoate 97%
  • Packaging:5g
  • Price:$ 102
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Methyl 3-Hydroxy-2-naphthoate 95%+
  • Packaging:1g
  • Price:$ 101
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Methyl 3-Hydroxy-2-naphthoate 95%+
  • Packaging:5g
  • Price:$ 323
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Methyl 3-Hydroxy-2-naphthoate 95%+
  • Packaging:2.500g
  • Price:$ 215
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  • Manufacture/Brand:Crysdot
  • Product Description:Methyl 3-Hydroxy-2-naphthoate 97%
  • Packaging:1000g
  • Price:$ 364
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  • Manufacture/Brand:Chemenu
  • Product Description:Methyl 3-Hydroxy-2-naphthoate 97%
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  • Price:$ 340
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:METHYL 3-HYDROXY-2-NAPHTHOATE 95.00%
  • Packaging:500G
  • Price:$ 4406.28
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Relevant articles and documentsAll total 54 Articles be found

Aggregation-Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells

Mehdi, Hassan,Gong, Weitao,Guo, Huimin,Watkinson, Michael,Ma, Hua,Wajahat, Ali,Ning, Guiling

, p. 13067 - 13075 (2017)

Two novel organic fluorophores, containing bis-naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation-induced emission (AIE) and a remarkable highly selective ratiometric fluorescence response towards Zn2+ in solution as well as in human liver cancer cells. The AIE behavior of this fluorophore was fully verified by fluorescence and UV/Vis spectroscopy, quantum yield calculations, and single-crystal X-ray diffraction, which revealed an intricate crystal packing system. Conversely, a fluorophore that lacks the isobutylene moiety did not exhibit any significant fluorescent properties as a result of its more flexible molecular structure that presumably allows free intramolecular rotational processes to occur.

Nucleophilic Partners in the Tandem Conjugate Addition-Dieckmann Condensation Reaction: 1. Synthesis of 1,2,3-Trisubstituted Naphthalenes

Martinez, Aaron D.,Deville, Jay P.,Stevens, Joel L.,Behar, Victor

, p. 991 - 992 (2004)

The scope and limitations of the tandem conjugate addition-Dieckmann condensation for the construction of 1,2,3-trisubstituted naphthalenes is defined. Viable nucleophilic partners in this methodology include organocuprates, active methylenes, and a variety of heteroatom initiators.

Cyclodimerization and Diels-Alder reaction of a spiroepoxycyclohexadienone with an o-quinodimethane structure

Bonnarme, Vincent,Mondon, Martine,Cousson, Alain,Gesson, Jean-Pierre

, p. 1143 - 1144 (1999)

Oxidation of 3-hydroxymethyl-2-naphthol with periodate affords a single exo-syn dimer arising from the intermediate ortho quinonoid spiroepoxycyclohexadienone; the latter can also be trapped by reactive dienophiles.

Oxorhenium(V) complexes with naphtholate-oxazoline ligands in the catalytic epoxidation of olefins

Terfassa, Belina,Schachner, J?rg A.,Traar, Pedro,Belaj, Ferdinand,M?sch Zanetti, Nadia C.

, p. 141 - 145 (2014)

Four oxorhenium(V) complexes 3a-d equipped with naphtholate-oxazoline based ligands 2a-d have been prepared and characterized by NMR, IR and mass spectroscopy as well as elemental analysis. Ligands 2a-d were prepared in a two-step procedure from commercially available starting materials. Ligands 2a-b and 2c-d are regioisomers to each other regarding the position of the -OH group and oxazoline moiety on the naphthol ring. Reaction of 2a-d with (NBu 4)[ReOCl4] in methanol under reflux gave oxorhenium(V) complexes 3a-d of the type [ReOCl(L)2] as green solids in acceptable to good yields. The molecular structures of complexes 3b and 3d have been determined via single crystal X-ray diffraction analysis and both display a distorted octahedral geometry. Complexes 3a-d are active catalysts for the epoxidation of cyclooctene with tert-butylhydroperoxide (TBHP) showing moderate conversions between 41% and 65%.

Synthesis and Clathrates of Oligomeric 2-O-Naphthoide Macrocycles

AlHujran, Tayel A.,Dawe, Louise N.,Collins, Julie,Georghiou, Paris E.

, p. 971 - 973 (2011)

New macrocyclic O-naphthoides 4-6 were synthesized from dehydration reactions of 3-hydroxy- and 7-tertbutyl- 3-hydroxy-2-naphthoic acids, respectively. Their X-ray structures were determined and their clathrate inclusion properties were investigated. Hexamer 6 formed an inclusion clathrate with four chloroform molecules. The trimer 5, by analogy with tri-o-thymotide, was studied for its potential optical resolution effects.

The influence of intramolecular hydrogen bonding on the order parameter and photostability properties of dichroic azo dyes in a nematic liquid crystal host

Griffiths, John,Feng, Kai-Chia

, p. 2333 - 2338 (1999)

It has been demonstrated that intramolecular hydrogen bonding in two classes of dichroic azo dyes has a generally detrimental effect on order parameter in a nematic liquid crystal host. Derivatives of 4-(N,N- diethylamino)-4'-nitroazobenzene with hydroxy groups intramolecularly hydrogen bonded to the azo group show lower order parameters in E7 nematic liquid crystal than the parent dye, but higher order parameters than corresponding methoxy dyes. 1-Arylazo-2-naphthols with a hydrogen bonding carboxamide group in position 3 exist exclusively in the hydrazone form and show even lower order parameters. Intramolecular hydrogen bonding also has a deleterious effect on photochemical stability.

Two new fluorescent Zn2+ sensors exhibiting different sensing mode with subtle structural changes

Mehdi, Hassan,Pang, Hongchang,Gong, Weitao,Wajahat, Ali,Manivannan, Kalavathi Dhinakaran,Shah, Shaheen,Ye, Jun-Wei,Ning, Guiling

, p. 378 - 386 (2017)

Two novel receptors HL-1 and HL-2 without and with hydroxyl groups were designed and synthesised. Both receptors showed highly selective coordination towards Zn2+ and exhibited diverse sensing behaviour due to the structural variations. HL-1 showed monotonous ‘turn-on’ response towards Zn2+ while HL-2 displayed highly Zn2+ sensitive ‘turn on’ and ‘ratiometric’ properties. Detailed Job plot experiment, single crystal data, 1H NMR, ESI-MS, UV–vis and density functional theory calculation studies were conducted to understand the binding modes of HL-1 and HL-2 with Zn2+. These results revealed the binding stoichiometric ratio between receptors and Zn2+ were 1:1 with low detection limits and high binding constants.

Synthesis and optical properties of copper(II) and nickel(II) complexes of a highly fluorescent morpholine-derivative

Sahoo, Priya Ranjan,Kumar, Arvind,Kumar, Ajeet,Kumar, Satish

, p. 559 - 570 (2019)

A morpholine substituted methyl 3-hydroxy-2-naphthoate was synthesized. The morpholine derivative displayed an intense fluorescence. Owing to the presence of suitable donor atoms, it was employed for the detection of transition metal ions. The crystals of copper and nickel complexes of the fluorescence active ligand were grown via vapor diffusion method. The ligand structure and its metal complexes were characterized using 1H NMR, IR, HR-MS and single crystal X-ray crystallography. The synthesized ligand displayed selective turn-off fluorescence response in the presence of Cu2+ and Ni2+ ions. Fluorescence active letters were encoded successfully on filter paper utilizing metal complexes as a tool towards digital writing.

Naphthaldehyde-derived ligands: Synthesis and their Ni(II) ion complexation

Al-Said, Naim H.,Mizyed, Shehadeh,Al-Sehemi, Abdullah G.,Kleeb, Amani M.

, p. 275 - 279 (2014)

Three novel diazacrown ether ligands, namely 17-, 18-, and 20-membered O2N2-donor macrocycles derived from 3,3′-[butane-1, 4-diylbis(oxy)]bis(2-naphthalenecarbaldehyde), were prepared and characterized by 1H and 13C NMR spectroscopy and mass spectra. Their host-guest interaction with Ni(II) was studied in DMSO-d 6 using 1H NMR spectroscopy. The stoichiometry of the complex in each case in the concentration range examined was determined to be 1:1 using the continuous variation method (Job's plot). The 17-membered O2N2-donor macrocycle in which the two nitrogen atoms are tethered by three methylene units binds Ni(II) more strongly than the other two macrocycles do. Graphical abstract: [Figure not available: see fulltext.]

A chromone hydrazide Schiff base fluorescence probe with high selectivity and sensitivity for the detection and discrimination of human serum albumin (HSA) and bovine serum albumin (BSA)

Fan, Jing,Li, Qing-Zhong,Li, Zhe,Liu, Hai-Bo,Wang, Zhi-Gang,Xie, Cheng-Zhi,Xu, Jing-Yuan,Yan, Xiao-Jing

, (2021/10/12)

The discrimination and identification of human serum albumin (HSA) and bovine serum albumin (BSA) is very important, which is due to the vital roles of two SAs in biological and pharmaceutical research. Based on structural screening and docking calculation from a series of homologues, a coumarin Schiff base fluorescent probe 3-hydroxy-N′-((4-oxo-4H-chromen-3-yl)methylene)-2-naphthohydrazide (HCNH) has been designed and synthesized, which could effectively discriminate HSA and BSA. The probe HCNH exhibited superior sensitivity toward HSA and BSA with the detection limits of 10.62 nM and 16.03 nM in PBS solution, respectively. The binding mechanism of HCNH with SAs was studied by Job's plot analysis, SA destruction and displacement assay. Molecular docking and DFT methods were utilized to provide deep insight into the spatial conformation change of HCNH and binding sites in HSA/BSA. The conformation of HCNH was significantly influenced by the microenvironment provided by HSA and BSA, therefore its fluorescence emission was affected correspondingly. Non-toxic probe HCNH could be successfully used for fluorescence bio-imaging of HSA in cancer cells, which is significantly different from normal cells and favors the application in medical diagnosis.

Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling

Zhao, Xiao-Jing,Li, Zi-Hao,Ding, Tong-Mei,Tian, Jin-Miao,Tu, Yong-Qiang,Wang, Ai-Fang,Xie, Yu-Yang

supporting information, p. 7061 - 7065 (2021/02/27)

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F–H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π–π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

A highly selective colorimetric and fluorescent probe for quantitative detection of Cu2+/Co2+: The unique ON-OFF-ON fluorimetric detection strategy and applications in living cells/zebrafish

Wang, Zhi-Gang,Wang, Yang,Ding, Xiao-Jing,Sun, Yu-Xuan,Liu, Hai-Bo,Xie, Cheng-Zhi,Qian, Jing,Li, Qing-Zhong,Xu, Jing-Yuan

, (2019/11/26)

Identifying and detecting similar target cations through combining “turn on” and “turn off” fluorescence mechanism is effective and challenging. Now a new colorimetric and ON-OFF-ON fluorescent probe N′-((7-(diethylamino)-2-oxo-2H-chromen-3-yl)methylene)-3-hydroxy-2-naphthohydrazide (L) was reported, which could detect Cu2+ and Co2+ in phosphate buffered CH3CH2OH-H2O solvent system. With the assistance of glutathione and pH adjustment, a unique ON-OFF-ON fluorescence detection strategy could be achieved for distinguishing Cu2+ and Co2+. The emission of probe could recover from the L-Cu2+ and L-Co2+ system by addition of GSH or adjusting pH value to 4, respectively, which is due to the abolishment of paramagnetic Cu2+/Co2+. Based on fluorescence titration experiments, the limit of detection was determined as 3.84 × 10?9 M and 4.55 × 10?9 M for Cu2+ and Co2+, respectively. Meanwhile, the detection limit reached 6.21 × 10?8 M for Cu2+ and 6.96 × 10?8 M for Co2+ according to absorbance signal output. Fast recognition of Cu2+/Co2+ can be achieved by obvious color changes from green to colorless under UV light, as well as from yellow to orange-red in room light. The binding mode of L toward Cu2+ and Co2+ have been systematically studied by Job's plot analysis, ESI-MS, IR and density functional theory calculations. Most strikingly, further practical applications of the probe L in fluorescence imaging were investigated in MCF-7 cells and zebrafish due to its low cytotoxicity and good optical properties, suggesting that L could serve as a fluorescent sensor for tracking Cu2+ and Co2+ in vivo.

Preparation of Acifluorfen-Based Ionic Liquids with Fluorescent Properties for Enhancing Biological Activities and Reducing the Risk to the Aquatic Environment

Cao, Yongsong,Li, Jianqiang,Niu, Junfan,Tang, Gang,Tang, Jingyue,Tang, Rong,Yang, Jiale,Zhang, Wenbing,Zhou, Zhiyuan

, p. 6048 - 6057 (2020/06/26)

In this work, 12 novel herbicidal ionic liquids (HILs) based on acifluorfen were prepared by pairing with the fluorescent hydrazides or different alkyl chains for increasing activities and reducing negative impacts on the aquatic environment. The results showed that the fluorescence of coumarin hydrazide in the HILs was applied as the internal and supplementary light source to meet the requirement of light wavelength range of acifluorfen, which improved the phytotoxicity of acifluorfen to weeds by enhancing singlet oxygen generation with increased sunlight utilization. The herbicidal activities of HILs were related positively with the length of chain of cation under high light intensity and depended mainly on the fluorescence characteristic of the cation under low light intensity, and the double salt IL forms of acifluorfen containing coumarin hydrazide and n-hexadecyltrimethylammonium had enhanced efficacies against broadleaf weeds in the field. Compared with acifluorfen sodium, HILs had lower water solubility, better surface activity, weaker mobility in soils, and higher decomposition temperature. These results demonstrated that HILs containing different cations provided a wider scope for fine-tuning of the physicochemical and biological properties of herbicides and established a promising way for the development of environmentally friendly herbicidal formulations.

Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade

Cai, Jinhui,Hu, Xu-Dong,Liu, Wen-Bo,Wang, Zhen-Kai,Yao, Fei,Zhang, Yun-Hao

supporting information, (2020/02/25)

A palladium-catalyzed intramolecular α-arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2-naphthols is reported. With ortho-bromobenzyl-substituted α-fluoroketones as the substrates and palladium acetate/triphenylphosphine as the catalyst, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields. The applications of the strategy are demonstrated by the synthesis of useful building blocks, such as naphtha[2,3-b]furan, naphthol AS-D, and ligands/catalysts. (Figure presented.).

Process route upstream and downstream products

Process route

methanol
67-56-1

methanol

3-Hydroxy-2-naphthoic acid
92-70-6

3-Hydroxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
With hydrogenchloride; reflux, 2 h, r.t., 12 h;
99%
With sulfuric acid; for 24h; Reflux;
98%
With acid;
90%
With sulfuric acid; for 21h; Heating;
89.5%
With sulfuric acid; for 10h; Reflux;
88%
With sulfuric acid; for 18h; Reflux;
88%
With sulfuric acid; Reflux;
88.1%
With sulfuric acid; for 12h; Heating;
87%
With sulfuric acid; at 65 ℃; for 24h;
80%
With sulfuric acid; for 44h; Reflux;
77%
With hydrogenchloride; In water; at 90 ℃;
65%
With hydrogenchloride; In water; for 4h; Heating;
65%
With hydrogenchloride;
With sulfuric acid;
With acid;
With sulfuric acid; Heating;
With trichlorophosphate;
With hydrogenchloride; for 2h; Heating;
With sulfuric acid; for 24h; Heating;
With sulfuric acid; for 12h; Reflux;
With hydrogenchloride; at 0 - 20 ℃; for 2h;
With sulfuric acid; at 80 ℃; for 8.5h;
With sulfuric acid;
3-Hydroxy-2-naphthoic acid; With thionyl chloride;
methanol;
With sulfuric acid; at 65 ℃; for 20h;
With sulfuric acid; Heating;
With sulfuric acid; at 65 ℃;
With sulfuric acid; at 65 ℃; for 24h;
With sulfuric acid; for 8h; Reflux;
With hydrogenchloride; In water; at 20 ℃; for 1h;
With sulfuric acid; at 65 ℃; for 8h;
With sulfuric acid; at 65 ℃;
With sulfuric acid; at 65 ℃; for 24h;
With sulfuric acid; Reflux;
With sulfuric acid; at 0 ℃; for 24h; Reflux;
1.62 g
With sulfuric acid;
Reflux;
48.5 g
With sulfuric acid; for 5h; Reflux;
for 10h; Reflux;
With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Inert atmosphere; Reflux;
With sulfuric acid; for 5h; Reflux;
o-Ethinyl-zimtsaeuremethylester
55384-90-2

o-Ethinyl-zimtsaeuremethylester

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
With pyridine N-oxide; bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; Tri(p-tolyl)phosphine; In chlorobenzene; at 100 ℃; for 15h; Inert atmosphere; Sealed tube;
80%
methyl 2-(2-bromobenzyl)-2-fluoro-3-oxobutanoate

methyl 2-(2-bromobenzyl)-2-fluoro-3-oxobutanoate

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
With palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; at 100 ℃; for 12h; Molecular sieve; Inert atmosphere;
85%
3-Hydroxy-2-naphthoic acid
92-70-6

3-Hydroxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

dl-3-hydroxy-7-di-n-propylamino-5,6,7,8-tetrahydro-2-naphthalenecarboxamide

dl-3-hydroxy-7-di-n-propylamino-5,6,7,8-tetrahydro-2-naphthalenecarboxamide

Conditions
Conditions Yield
With potassium hydrogencarbonate; dimethyl sulfate; In acetone;
methanol
67-56-1

methanol

3-methoxy-2-naphthoic acid
883-62-5

3-methoxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
methanol; With sulfuric acid; at 45 ℃;
3-methoxy-2-naphthoic acid; at 76 - 83 ℃; for 6h;
3-(2-methoxycarbonylmethyl-phenyl)-propynoic acid methyl ester
425376-47-2

3-(2-methoxycarbonylmethyl-phenyl)-propynoic acid methyl ester

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
In dimethyl sulfoxide; at 25 ℃; for 3.5h;
84%
3-Hydroxy-2-naphthoic acid
92-70-6

3-Hydroxy-2-naphthoic acid

methyl iodide
74-88-4

methyl iodide

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;
dimethyl sulfate
77-78-1

dimethyl sulfate

3-Hydroxy-2-naphthoic acid
92-70-6

3-Hydroxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
With sodium hydrogencarbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; at 40 ℃; for 0.25h;
80%
3-Hydroxy-2-naphthoic acid
92-70-6

3-Hydroxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: SOCl2
With thionyl chloride;
tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

3-Hydroxy-2-naphthoic acid
92-70-6

3-Hydroxy-2-naphthoic acid

3-hydroxy-2-naphthoic acid methyl ester
883-99-8

3-hydroxy-2-naphthoic acid methyl ester

Conditions
Conditions Yield
With copper quinolate; In water; dimethyl sulfoxide; at 120 ℃; for 24h;
18%

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