88319-43-1

Basic information

• Product Name: BETA-T-BUTYL-D-ALANINE
• Synonyms: 1-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER;(R)-3-T-BUTYL-BETA-ALANINE;(R)-3-AMINO-4,4-DIMETHYL-PENTANOIC ACID;D-gamma-methylleucine;(R)-3-t-Butyl--alanine;(S)-4-T-BUTYL-BETA-ALANINE;D-Neopentylglycine, 4-Methyl-L-leucine, ss-t-Butyl-D-alanine, (R)-2-Amino-4,4-dimethyl-pentanoic acid;H-D-NptGly-OH
• CAS NO: 88319-43-1
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 88319-43-1.mol

Chemical Properties

• Boiling Point: 236℃
• Flash Point: 97℃
• Appearance: /
• Density: 1.016
• Vapor Pressure: 0.0507mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: Store at 0-5°C
• PKA: 2.56±0.23(Predicted)
• CAS DataBase Reference: BETA-T-BUTYL-D-ALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-T-BUTYL-D-ALANINE(88319-43-1)
• EPA Substance Registry System: BETA-T-BUTYL-D-ALANINE(88319-43-1)

Safety Data

• Hazardous Substances Data: 88319-43-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C9H17NO2/c1-12-8(11)9(7-10)5-3-2-4-6-9/h2-7,10H2,1H3

Upstream product

• 88319-40-8 N-formyl-D-neopentylglycine 
• 88319-40-8 N-formyl-L-neopentylglycine 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 88319-38-4 2-cyano-4,4-dimethylpentanoic acid 
• 479353-90-7 2-amino-4,4-dimethyl-pentanenitrile 
• 34906-87-1 4,4-dimethyl-2-oxo-pentanoic acid 
• 3060-50-2 2,2-diphenylglycine 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 
• 630-19-3 pivalaldehyde 
• 88319-39-5 2-carbamoyl-4,4-dimethylpentanoic acid 
• 60122-72-7 4,4-Dimethyl-2(R)-aminopentanoic acid 
• 39168-28-0 (E)-2-cyano-4,4-dimethyl-pent-2-enoic acid 

Downstream Products

• 88319-46-4 N-2-nitrobenzenesulfenyl-L-neopentylglycine 
• 112674-65-4 acetyl-L-neopentylglycine 
• 1026472-43-4 (R)-2-(4-Methoxy-benzenesulfonylamino)-4,4-dimethyl-pentanoic acid 
• 139551-74-9 (R)-N-[(fluoren-9-yl)methoxycarbonyl]-2-amino-4,4-dimethylpentanoic acid 
• 1026981-78-1 (R)-2-[(4-Methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-4,4-dimethyl-pentanoic acid tert-butoxy-amide 
• 114990-91-9 (2R)-2-hydroxy-4,4-dimethylpentanoic acid 
• 112695-98-4 (2R)-2-{[(tert-butoxy)carbonyl]amino}-4,4-dimethylpentanoic acid 
• 1025952-33-3 (R)-2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-4,4-dimethyl-pentanoic acid tert-butyl ester 
• 1025804-35-6 (R)-2-(4-Methoxy-benzenesulfonylamino)-4,4-dimethyl-pentanoic acid tert-butyl ester 
• 88319-44-2 N-benzoyloxycarbonyl-L-neopentylglycine 
• 1010691-40-3 (S)-2-(2-bromophenyl)-4-neopentyl-4,5-dihydrooxazole 

Relevant articles and documents

A new type of chiral-pyridoxamines for catalytic asymmetric transamination of α-keto acids

A new type of chiral pyridoxamines bearing an adjacent chiral stereocenter has been developed via multi-step synthesis. The pyridoxamines displayed catalytic activity in asymmetric transamination of α-keto acids to give a variety of optically active amino acids in 27–78% yields with 34–62% ee's under very mild conditions. This work provides a synthetic strategy to construct new chiral pyridoxamines using bromopyridine 7 as a key synthon and also represents an early example of the applications of chiral pyridoxamines in asymmetric catalysis.

PEPTIDES CONTAINING A NEOPENTYLGLYCINE RESIDUE

Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms.Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.