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96-96-8

96-96-8

Identification

  • Product Name:Benzenamine,4-methoxy-2-nitro-

  • CAS Number: 96-96-8

  • EINECS:202-547-2

  • Molecular Weight:168.152

  • Molecular Formula: C7H8N2O3

  • HS Code: Oral rat LD50: 14100 mg/kg

  • Mol File:96-96-8.mol

Synonyms:p-Anisidine,2-nitro- (8CI);1-Amino-2-nitro-4-methoxybenzene;2-Nitro-4-methoxyaniline;2-Nitro-4-methoxybenzenamine;2-Nitro-p-anisidine;3-Nitro-4-aminoanisole;4-Amino-1-methoxy-3-nitrobenzene;4-Amino-3-nitroanisole;4-Methoxy-2-nitroaniline;4-Methoxy-2-nitrobenzenamine;4-Methoxy-2-nitrohbenzenamine;4-Methoxy-2-nitrophenylamine;4-Methoxy-o-nitroaniline;Acco Fast Bordeaux GP salt;Atul Fast Bordeaux GP Base;Azoene Fast Bordeaux GP Salt;Bordeaux Base Ciba IV;Bordeaux GPS Salt;o-Nitro-p-anisidine;

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Safety information and MSDS view more

  • Pictogram(s):VeryT+

  • Hazard Codes:T+,T

  • Signal Word:Danger

  • Hazard Statement:H300 Fatal if swallowedH310 Fatal in contact with skin H330 Fatal if inhaled H373 May cause damage to organs through prolonged or repeated exposure H412 Harmful to aquatic life with long lasting effects

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Methoxy-2-nitroaniline 98%
  • Packaging:100g
  • Price:$ 33.5
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Methoxy-2-nitroaniline 98%
  • Packaging:500g
  • Price:$ 100
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:4-Methoxy-2-nitroaniline(2-Nitro-p-anisidine)
  • Packaging:250 mg
  • Price:$ 650
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:4-Methoxy-2-nitroaniline 98%
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  • Price:$ 90
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:4-Methoxy-2-nitroaniline 98%
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  • Manufacture/Brand:Frontier Specialty Chemicals
  • Product Description:4-Methoxy-2-nitroaniline 98%
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:4-Methoxy-2-nitroaniline 95%
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  • Manufacture/Brand:Aronis compounds
  • Product Description:(4-methoxy-2-nitrophenyl)amine
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:4-Methoxy-2-nitroaniline 99%
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:4-Methoxy-2-nitroaniline 99%
  • Packaging:2500g
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Relevant articles and documentsAll total 38 Articles be found

Fused tricyclic derivative as FGFR4 inhibitor

-

, (2021/05/12)

The present invention provides a fused tricyclic derivative that is the selective inhibitor of fibroblast growth factor receptor 4 (FGFR4), a pharmaceutical composition containing the compound, a method of making the compound and a method of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

Method for synthesizing 4-methoxy-2-nitroaniline by adopting continuous flow reactor

-

, (2020/10/05)

The invention relates to the technical field of organic synthesis, and discloses a method for synthesizing 4-methoxy-2-nitroaniline by using a continuous flow reactor. The method comprises the following steps: S1, respectively adding a 4-methoxyaniline solution and acetic anhydride into a continuous flow reactor I, and carrying out an acetylation reaction to obtain a reaction solution I containing4-methoxyacetanilide; S2, respectively adding a nitration reagent and the reaction solution I into a continuous flow reactor II, and carrying out a nitration reaction to obtain a reaction solution IIcontaining 4-methoxy-2-nitroacetanilide; S3, respectively adding hydrolysate and the reaction solution II into a continuous flow reactor III, and carrying out a hydrolysis reaction to obtain a reaction solution III containing 4-methoxy-2-nitroaniline; and S4, carrying out post-treatment on the reaction solution III to obtain 4-methoxy-2-nitroaniline. The method is high in reaction speed, small inamount of byproduct 4-methoxy-3-nitroaniline, high in heat and mass transfer efficiency, high in reaction safety, high in selectivity, high in yield and purity and convenient in after-treatment.

Sodium persulfate-promoted site-selective synthesis of mononitroarylamines under transition-metal-free conditions

Xie, De-Xun,Yu, Hui-Juan,Liu, Hui,Xue, Wei-Cai,Qin, Yuan-Shou,Shao, Guang

, p. 1157 - 1165 (2019/01/24)

A practical preparation of nitroarylamines from protected arylamines was herein disclosed. In this system, sodium nitrite acted as a nitration reagent in the presence of sodium persulfate without any transition-metal catalysts. This efficient site-selective protocol took place at room temperature for a short time through a free radical pathway.

A O-nitro to the preparation method of the anisidine

-

, (2018/07/15)

The invention relates to a O-nitro to anisidine preparation method. Characterized in that to the anisidine as raw materials, by acetylation, mixed acid nitration to obtain the 4 - methoxy - 2 - nitro acetanilide, and hydrolyzed to from 2 - nitro - 4 - methoxybenzene elimination and to acetaminophen as raw materials, by methylation, antirust, the reduction reaction of the nitro to synthetic O-anisidine.

NOVEL FYN KINASE INHIBITORS

-

, (2017/03/28)

The present invention relates to the novel therapies to treat neurodegenerative diseases such as Parkinson's disease (PD). The present invention relates to novel small molecule inhibitors of Fyn Kinase and for testing activity against Parkinsons's disease models compounds that inhibit Fyn kinase having the following formula. (I)

Process route upstream and downstream products

Process route

3-nitroanisole
555-03-3

3-nitroanisole

2-methoxy-4-nitrophenylamine
97-52-9

2-methoxy-4-nitrophenylamine

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
With potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;
12%
48%
3-nitroanisole
555-03-3

3-nitroanisole

2-methoxy-6-nitroaniline
16554-45-3

2-methoxy-6-nitroaniline

2-methoxy-4-nitrophenylamine
97-52-9

2-methoxy-4-nitrophenylamine

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
With 2,4,6-trichlorosulfenamide; potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;
21%
4%
46%
With O-Methylhydroxylamin; potassium tert-butylate; copper(l) chloride; In N,N-dimethyl-formamide; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
With O-Methylhydroxylamin; copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Further Variations:; also without CuCl; Product distribution;
tetramethylammonium
51-92-3

tetramethylammonium

4-hydroxy-2-nitroaniline
610-81-1

4-hydroxy-2-nitroaniline

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

trimethylamine
75-50-3

trimethylamine

Conditions
Conditions Yield
With water; das dabei erhaltene Tetramethylammoniumsalz nach dem Trocknen im Vakuumexsiccator erhitzt;
3-nitroanisole
555-03-3

3-nitroanisole

2-methoxy-6-nitroaniline
16554-45-3

2-methoxy-6-nitroaniline

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
56%
methyl 3-({[4-(methyloxy)-2-nitrophenyl]amino}methyl)benzoate
1097777-74-6

methyl 3-({[4-(methyloxy)-2-nitrophenyl]amino}methyl)benzoate

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2.5h;
4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
With nickel ammonium sulfate; nitric acid; In chloroform; water; at 20 ℃; for 3h;
90%
Multi-step reaction with 3 steps
1: 85 percent / acetic acid / 2 h / 110 °C
2: 91 percent / nitric acid; sulfuric acid / 0 - 5 °C
3: 99 percent / NaOH; KOH / H2O / 0.5 h / Heating
With potassium hydroxide; sodium hydroxide; sulfuric acid; nitric acid; acetic acid; In water;
Multi-step reaction with 3 steps
1: sodium acetate
2: nitric acid / 36 °C
3: concentrated sulfuric acid
With sulfuric acid; nitric acid; sodium acetate;
Multi-step reaction with 3 steps
1: sodium acetate; alcohol
2: glacial acetic acid; nitric acid / 5 - 10 °C
3: bei der Verseifung
With ethanol; nitric acid; sodium acetate; acetic acid;
Multi-step reaction with 3 steps
1: alcohol; sodium acetate
2: glacial acetic acid; nitric acid / 10 - 22 °C
3: bei der Verseifung
With ethanol; nitric acid; sodium acetate; acetic acid;
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane
2: nitric acid; acetic anhydride / dichloromethane
3: hydrogenchloride / water / Reflux
With hydrogenchloride; nitric acid; acetic anhydride; triethylamine; In dichloromethane; water;
Multi-step reaction with 3 steps
1: dichloromethane / 1 h / 20 °C
2: nitric acid; acetic acid / 0.5 h / 0 °C
3: hydrogenchloride / water / 2 h / Reflux
With hydrogenchloride; nitric acid; acetic acid; In dichloromethane; water;
Multi-step reaction with 3 steps
1: acetic acid
2: nitric acid; sulfuric acid
3: sodium hydroxide / methanol
With sulfuric acid; nitric acid; acetic acid; sodium hydroxide; In methanol;
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
1.2: 2.33 h / 0 - 20 °C
2.1: nitric acid / dichloromethane / 2.33 h / 20 °C / Reflux
3.1: hydrogenchloride / water / 18 h / Reflux
With hydrogenchloride; nitric acid; triethylamine; In dichloromethane; water;
Multi-step reaction with 3 steps
1: acetic acid / water / 0 - 95 °C
2: acetic acid; nitric acid / water / 70 °C / Cooling with ice
3: potassium hydroxide; water / methanol / 0.25 h / 90 - 95 °C
With water; nitric acid; acetic acid; potassium hydroxide; In methanol; water;
Multi-step reaction with 3 steps
1: 0.5 h / Sonication
2: nitric acid; sulfuric acid / water / 2 h / 0 - 20 °C
3: water; sodium hydroxide / 1 h / 60 °C
With sulfuric acid; water; nitric acid; sodium hydroxide; In water;
Multi-step reaction with 3 steps
1.1: acetic acid / Flow reactor
1.2: 2.22 h / 25 °C / Flow reactor
2.1: sulfuric acid; nitric acid / 1.67 h / 25 °C / Flow reactor
3.1: sodium hydroxide; water / 6.67 h / 40 °C / Flow reactor
With sulfuric acid; water; nitric acid; acetic acid; sodium hydroxide;
N-(4-methoxy-2-nitrophenyl) pyrimidin-2-amine

N-(4-methoxy-2-nitrophenyl) pyrimidin-2-amine

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
N-(4-methoxy-2-nitrophenyl) pyrimidin-2-amine; With triethylsilane; trifluoroacetic acid; at 50 ℃; Inert atmosphere;
With acetic acid; hydrazine; In methanol; at 20 ℃; regioselective reaction; Inert atmosphere;
72%
4-hydroxy-2-nitroaniline
610-81-1

4-hydroxy-2-nitroaniline

methyl iodide
74-88-4

methyl iodide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
4-hydroxy-2-nitroaniline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;
methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 24h; Inert atmosphere;
90%
4-hydroxy-2-nitroaniline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h; Cooling with ice;
methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h;
89%
With potassium carbonate; In acetone;
N-(2-nitro-4-methoxyphenyl) 2-pyridinecarboxamide

N-(2-nitro-4-methoxyphenyl) 2-pyridinecarboxamide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; at 90 ℃; for 8h;
95%
4-methoxyacetanilide
51-66-1

4-methoxyacetanilide

4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 91 percent / nitric acid; sulfuric acid / 0 - 5 °C
2: 99 percent / NaOH; KOH / H2O / 0.5 h / Heating
With potassium hydroxide; sodium hydroxide; sulfuric acid; nitric acid; In water;
Multi-step reaction with 2 steps
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
2: conc. sulfuric acid / 0.25 h / 100 °C
With sulfuric acid; nitric acid;
Multi-step reaction with 2 steps
1: diluted acetic acid; nitric acid / 60 - 65 °C
2: aqueous KOH-solution
With potassium hydroxide; nitric acid; acetic acid;
Multi-step reaction with 2 steps
1: acetic acid; nitric acid / zuletzt bei 60grad
2: aqueous ethanolic NaOH-solution
With sodium hydroxide; nitric acid; acetic acid;
Multi-step reaction with 2 steps
1: acetic acid; nitric acid / zuletzt bei 60grad
2: aq.-ethanolic hydrochloric acid
With hydrogenchloride; nitric acid; acetic acid;
Multi-step reaction with 2 steps
1: nitric acid
2: alcoholic potash
With nitric acid; potassium carbonate;
Multi-step reaction with 2 steps
1: HNO3, AcOH
2: KOH, EtOH
With potassium hydroxide; ethanol; nitric acid; acetic acid;
Multi-step reaction with 2 steps
1: nitric acid; acetic anhydride / dichloromethane
2: hydrogenchloride / water / Reflux
With hydrogenchloride; nitric acid; acetic anhydride; In dichloromethane; water;
Multi-step reaction with 2 steps
1: nitric acid; acetic acid / 0.5 h / 0 °C
2: hydrogenchloride / water / 2 h / Reflux
With hydrogenchloride; nitric acid; acetic acid; In water;
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid
2: sodium hydroxide / methanol
With sulfuric acid; nitric acid; sodium hydroxide; In methanol;
Multi-step reaction with 2 steps
1: nitric acid / dichloromethane / 2.33 h / 20 °C / Reflux
2: hydrogenchloride / water / 18 h / Reflux
With hydrogenchloride; nitric acid; In dichloromethane; water;
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / water / 2 h / 0 - 20 °C
2: water; sodium hydroxide / 1 h / 60 °C
With sulfuric acid; water; nitric acid; sodium hydroxide; In water;
Multi-step reaction with 2 steps
1: nitric acid / dichloromethane / 2 h / 40 °C
2: hydrogenchloride / water / 12 h / 100 °C
With hydrogenchloride; nitric acid; In dichloromethane; water;

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