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Azoic Diazo Component 1, also known as 4-Methoxy-2-nitroaniline, is a substituted aniline compound that is 3-nitroanisole in which the hydrogen para to the methoxy group is replaced by an amino group. It is an orange crystalline powder with specific chemical properties.

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  • 96-96-8 Structure
  • Basic information

    1. Product Name: Azoic Diazo Component 1
    2. Synonyms: 4-Methoxy-2-nitroaniline (2-Nitro-p-anisidine);2-nitro-4-Methoxyaniline (4-Methoxy-2-nitroaniline);4-Methoxy-2-nitroaniline, 99%, 99%;sanyofastbordeauxsaltgp;Shinnippon Fast Bordeaux GP Base;shinnipponfastbordeauxgpbase;Sugai Fast Bordeaux GP Base;sugaifastbordeauxgpbase
    3. CAS NO:96-96-8
    4. Molecular Formula: C7H8N2O3
    5. Molecular Weight: 168.15
    6. EINECS: 202-547-2
    7. Product Categories: Intermediates of Dyes and Pigments;Anilines, Aromatic Amines and Nitro Compounds;Organics
    8. Mol File: 96-96-8.mol
  • Chemical Properties

    1. Melting Point: 123-126 °C(lit.)
    2. Boiling Point: 337.07°C (rough estimate)
    3. Flash Point: 158.4 °C
    4. Appearance: /
    5. Density: 1.2089 (estimate)
    6. Vapor Pressure: 9.93E-05mmHg at 25°C
    7. Refractive Index: 1.6010 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 0.96±0.10(Predicted)
    11. Water Solubility: slightly soluble
    12. BRN: 880318
    13. CAS DataBase Reference: Azoic Diazo Component 1(CAS DataBase Reference)
    14. NIST Chemistry Reference: Azoic Diazo Component 1(96-96-8)
    15. EPA Substance Registry System: Azoic Diazo Component 1(96-96-8)
  • Safety Data

    1. Hazard Codes: T+,T
    2. Statements: 26/27/28-33-52/53
    3. Safety Statements: 28-36/37-45-61
    4. RIDADR: UN 2811 6.1/PG 2
    5. WGK Germany: 2
    6. RTECS: BY4415000
    7. TSCA: Yes
    8. HazardClass: 6.1
    9. PackingGroup: II
    10. Hazardous Substances Data: 96-96-8(Hazardous Substances Data)

96-96-8 Usage

Uses

Used in Chemical Synthesis Industry:
Azoic Diazo Component 1 is used as an intermediate for the synthesis of dyes, pigments, and other chemical compounds due to its unique chemical structure and reactivity.
Used in Molluscicidal Applications:
Azoic Diazo Component 1 is used as a molluscicidal agent, exhibiting activity against mollusks, which can be beneficial in controlling their populations in various settings.
Used in Toxicological Studies:
Azoic Diazo Component 1 has been shown to be toxic to some wild and domestic birds and mice, making it a subject of interest in toxicological research and studies on hemolytic anemia.

Check Digit Verification of cas no

The CAS Registry Mumber 96-96-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 6 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 96-96:
(4*9)+(3*6)+(2*9)+(1*6)=78
78 % 10 = 8
So 96-96-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,8H2,1H3

96-96-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methoxy-2-nitroaniline

1.2 Other means of identification

Product number -
Other names 4-Methoxy-2-nitroaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:96-96-8 SDS

96-96-8Relevant articles and documents

Fused tricyclic derivative as FGFR4 inhibitor

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Paragraph 0597; 0603-0607, (2021/05/12)

The present invention provides a fused tricyclic derivative that is the selective inhibitor of fibroblast growth factor receptor 4 (FGFR4), a pharmaceutical composition containing the compound, a method of making the compound and a method of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

Method for synthesizing 4-methoxy-2-nitroaniline by adopting continuous flow reactor

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Paragraph 0038; 0040; 0045; 0047; 0049; 0054; 0056; 0058, (2020/10/05)

The invention relates to the technical field of organic synthesis, and discloses a method for synthesizing 4-methoxy-2-nitroaniline by using a continuous flow reactor. The method comprises the following steps: S1, respectively adding a 4-methoxyaniline solution and acetic anhydride into a continuous flow reactor I, and carrying out an acetylation reaction to obtain a reaction solution I containing4-methoxyacetanilide; S2, respectively adding a nitration reagent and the reaction solution I into a continuous flow reactor II, and carrying out a nitration reaction to obtain a reaction solution IIcontaining 4-methoxy-2-nitroacetanilide; S3, respectively adding hydrolysate and the reaction solution II into a continuous flow reactor III, and carrying out a hydrolysis reaction to obtain a reaction solution III containing 4-methoxy-2-nitroaniline; and S4, carrying out post-treatment on the reaction solution III to obtain 4-methoxy-2-nitroaniline. The method is high in reaction speed, small inamount of byproduct 4-methoxy-3-nitroaniline, high in heat and mass transfer efficiency, high in reaction safety, high in selectivity, high in yield and purity and convenient in after-treatment.

Sodium persulfate-promoted site-selective synthesis of mononitroarylamines under transition-metal-free conditions

Xie, De-Xun,Yu, Hui-Juan,Liu, Hui,Xue, Wei-Cai,Qin, Yuan-Shou,Shao, Guang

, p. 1157 - 1165 (2019/01/24)

A practical preparation of nitroarylamines from protected arylamines was herein disclosed. In this system, sodium nitrite acted as a nitration reagent in the presence of sodium persulfate without any transition-metal catalysts. This efficient site-selective protocol took place at room temperature for a short time through a free radical pathway.

A O-nitro to the preparation method of the anisidine

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Paragraph 0009; 0011; 0012, (2018/07/15)

The invention relates to a O-nitro to anisidine preparation method. Characterized in that to the anisidine as raw materials, by acetylation, mixed acid nitration to obtain the 4 - methoxy - 2 - nitro acetanilide, and hydrolyzed to from 2 - nitro - 4 - methoxybenzene elimination and to acetaminophen as raw materials, by methylation, antirust, the reduction reaction of the nitro to synthetic O-anisidine.

NOVEL FYN KINASE INHIBITORS

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Page/Page column 24; 25, (2017/03/28)

The present invention relates to the novel therapies to treat neurodegenerative diseases such as Parkinson's disease (PD). The present invention relates to novel small molecule inhibitors of Fyn Kinase and for testing activity against Parkinsons's disease models compounds that inhibit Fyn kinase having the following formula. (I)

Salicylic Acid-Catalyzed One-Pot Hydrodeamination of Aromatic Amines by tert-Butyl Nitrite in Tetrahydrofuran

Felipe-Blanco, Diego,Alonso, Francisco,Gonzalez-Gomez, Jose C.

supporting information, p. 2857 - 2863 (2017/08/23)

A significant acceleration in the hydrodeamination of in situ formed diazonium salts (from aromatic amines) has been observed in the presence of 10-mol% salicylic acid, using tetrahydrofuran as the hydrogen donor. The reaction proceeds efficiently at 20 °C for a wide range of substituted anilines, even at 10-mmol scale, without any other additive. The same protocol has been adapted to the selective deuterodeamination of some aromatic amines. Control experiments clearly show that aryl radicals are involved in the reaction mechanism. (Figure presented.).

Palladium(II)-catalyzed, heteroatom-directed, regioselective C-H nitration of anilines using pyrimidine as a removable directing group

Pawar, Govind Goroba,Brahmanandan, Abhilashamole,Kapur, Manmohan

, p. 448 - 451 (2016/02/18)

A new palladium-catalyzed, heteroatom-directed strategy for C-H nitration of anilines is described. This C-H functionalization reaction is highly ortho-selective and results in very good yields. The highlight of the work is the use of pyrimidine as the removable directing group. This approach constitutes one of the rare methods of ortho-nitration of anilines, a reaction that is normally very difficult to achieve via traditional approaches.

Indole and indazole compounds as an inhibitor of cellular necrosis

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Paragraph 0339; 0344-0346; 0349, (2016/10/08)

The present invention refers to a formula (1) compounds of, pharmaceutically acceptable salts or isomers thereof thereof, and characterized by by containing as active ingredients-associated diseases, cell death and method for the prevention or treatment of relates and compositions. [Formula 1] In formula said R 1, R 2, R 3, R 4, R 5, R 6, A, X, n and m to equal the specification.

Copper-catalyzed mild nitration of protected anilines

Hernando, Elier,Castillo, Rafael R.,Rodríguez, Nuria,G?mez Arrayás, Ram?n,Carretero, Juan C.

supporting information, p. 13854 - 13859 (2016/02/18)

A practical copper-catalyzed direct nitration of protected anilines, by using one equivalent of nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N-protecting group and arene substitution), and high functional-group tolerance. Dinitration with two equivalents of nitric acid is also feasible. Practical and reliable: A Cu-catalyzed selective nitration of para- and ortho-substituted aniline derivatives by using one equivalent of HNO3 has been developed that produces water as the only stoichiometric byproduct (see scheme; PG=protecting group). This method is compatible with strongly electron-deficient substrates, enabling dinitration (by using 2.0 equiv of HNO3). This method allows for a rapid access to relevant nitrogen-containing heterocyclic architectures.

Cyclometalated iridium(III) bipyridyl-phenylenediamine complexes with multicolor phosphorescence: Synthesis, electrochemistry, photophysics, and intracellular nitric oxide sensing

Law, Wendell Ho-Tin,Leung, Kam-Keung,Lee, Lawrence Cho-Cheung,Poon, Che-Shan,Liu, Hua-Wei,Lo, Kenneth Kam-Wing

, p. 1316 - 1329 (2014/06/09)

We present a new class of phosphorescent cyclometalated iridium(III) bipyridyl-phenylenediamine complexes [Ir(N^C)2(bpy-DA)](PF 6) (bpy-DA=4-(N-(2-amino-5-methoxyphenyl)aminomethyl)-4′- methyl-2,2′-bipyridine; HN^C=2-(2,4-difluorophenyl)pyridine (Hdfppy) (1-a), 2-phenylpyridine (Hppy) (2-a), 2-phenylquinoline (Hpq) (3-a), 2-phenylcinchoninic acid methyl ester (Hpqe) (4-a)) and their triazole counterparts [Ir(N^C)2(bpy-T)](PF6) (bpy-T=4-((6- methoxybenzotriazol-1-yl)methyl)-4′-methyl-2,2′-bipyridine; HN^C=Hdfppy (1-b), Hppy (2-b), Hpq (3-b), Hpqe (4-b)). Upon photoexcitation, the diamine complexes exhibited fairly weak green to red phosphorescence under ambient conditions whereas the triazole derivatives emitted strongly. The photophysical properties of complexes 2-a and 2-b have been studied in more detail. Upon protonation, the diamine complex 2-a displayed increased emission intensity, but the emission properties of its triazole counterpart complex 2-b were independent on the pH value of the solution. Also, complex 2-a was found to be readily converted into complex 2-b upon reaction with NO under aerated conditions, resulting in substantial emission enhancement of the solution. The reaction was highly specific toward NO over other reactive oxygen and nitrogen species (RONS) as revealed by spectroscopic analyses. The lipophilicity and cellular uptake efficiency of the diamine complexes have been examined and correlated to their molecular structures. Also, cell-based assays showed that these complexes were noncytotoxic toward human cervix epithelioid carcinoma (HeLa) cells (at 10 μM, 4 h, percentage survival ≈80-95-%). Additionally, the diamine complexes have been used to visualize intracellular NO generated both exogenously in HeLa cells and endogenously in RAW 264.7 murine macrophages by laser-scanning confocal microscopy. Visualizing NO: Phosphorescent cyclometalated iridium(III) bipyridyl-phenylenediamine complexes have been designed as intracellular NO sensors. They react selectively with NO over other reactive oxygen and nitrogen species and are converted into their triazole counterparts, resulting in significant emission enhancement. The diamine complexes show low cytotoxic activity and are capable of sensing intracellular NO generated exogenously in HeLa cells and endogenously in RAW 264.7 murine macrophages.