96145-98-1

Basic information

• Product Name: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol
• Synonyms: 5-Hydroxy-1-phenyl-3-trifluoromethylpyrazole;1-Phenyl-3-(trifluoromethyl)-1H-pyrazol-5-ol;5-Hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazole;2-Phenyl-5-trifluoro
• CAS NO: 96145-98-1
• Molecular Formula: C₁₀H₇F₃N₂O
• Molecular Weight: 228.17
• Product Categories: Heterocyclic Compounds
• Mol File: 96145-98-1.mol

Chemical Properties

• Boiling Point: 318.4 °C at 760mmHg
• Flash Point: 146.4 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol(96145-98-1)
• EPA Substance Registry System: 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol(96145-98-1)

Safety Data

• Hazardous Substances Data: 96145-98-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol is used as a key intermediate in the synthesis of 5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, which is an inhibitor of ADAMTS-5. This enzyme plays a crucial role in the degradation of extracellular matrix proteins, and its inhibition can be beneficial in treating various diseases, such as osteoarthritis and other inflammatory conditions.
Additionally, due to its unique structure and properties, 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol may also be employed as a building block for the development of other pharmaceutical compounds with potential therapeutic applications. Its versatility and reactivity make it a promising candidate for further research and drug discovery efforts.

InChI:InChI=1/C10H7F3N2O/c11-10(12,13)8-6-9(16)15(14-8)7-4-2-1-3-5-7/h1-6,16H

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 83643-84-9 methyl 4,4,4-trifluoroacetoacetate 
• 100-63-0 phenylhydrazine 
• 122431-24-7 (N-((2-chloro-3,5-di(trifluoromethyl)phenyl)amino)carbonyl)(2,6-difluorophenyl)formamide 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 1522-43-6 ethyl 3-oxo-4,4,4-trifluorobutanoate enol 

Downstream Products

• 159391-22-7 (S)-3-Benzyloxycarbonylamino-4-oxo-5-(2-phenyl-5-trifluoromethyl-2H-pyrazol-3-yloxy)-pentanoic acid tert-butyl ester 
• 877129-27-6 3-{3-methyl-2-[2-(naphthalen-1-yloxy)-acetylamino]-butyrylamino}-4-oxo-5-(2-phenyl-5-trifluoromethyl-2H-pyrazol-3-yloxy)-pentanoic acid tert-butyl ester 
• 914399-29-4 5-ethoxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazole 
• 318288-78-7 5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde 
• 946409-60-5 5-difluoromethoxy-4-hydroxymethyl-1-phenyl-3-trifluoromethylpyrazole 
• 1402820-78-3 6-amino-4-(4-nitrophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 443886-29-1 6-amino-4-(3-methoxyphenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 443886-44-0 6-amino-4-(furan-2-yl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 

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