96212-86-1

Basic information

• Product Name: (Z)-1-Bromo-1,2-diphenyl-1-butene
• Synonyms: (Z)-1-Bromo-1,2-diphenyl-1-butene
• CAS NO: 96212-86-1
• Molecular Formula: C₁₆H₁₅Br
• Molecular Weight: 0
• Mol File: 96212-86-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-1-Bromo-1,2-diphenyl-1-butene(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-1-Bromo-1,2-diphenyl-1-butene(96212-86-1)
• EPA Substance Registry System: (Z)-1-Bromo-1,2-diphenyl-1-butene(96212-86-1)

Safety Data

• Hazardous Substances Data: 96212-86-1(Hazardous Substances Data)

Upstream product

• 16282-16-9 1,2-diphenyl-butan-1-one 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 96212-85-0 (Z)-1,2-diphenyl-1-(trimethylsilyl)-1-butene 
• 811-49-4 ethyllithium 
• 501-65-5 diphenyl acetylene 
• 28557-00-8 phenylzinc chloride 
• 96212-84-9 (E)-1-bromo-2-phenyl-1-(trimethylsilyl)-1-butene 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 622-76-4 1-phenyl-1-butyne 
• 1078-58-6 diphenylzinc 

Downstream Products

• 6462-18-6 (Z)-(1-(4-methoxyphenyl)but-1-ene-1,2-diyl)dibenzene 
• 155701-60-3 (Z)-1,2-Diphenyl-1-(4-formylphenyl)-1-butene 
• 10540-29-1 tamoxifen 
• 155701-61-4 GW 5638 
• 69967-80-2 1-phenyl-1-(p-hydroxyphenyl)-2-phenylbut-1-ene 

Relevant articles and documents

Process development for a large scale stereoselective synthesis of (Z)-(1-bromobut-1-ene-1,2-diyl)dibenzene, a key intermediate of a selective estrogen receptor modulator

Two efficient large scale syntheses of (Z)-(1-bromobut-1-ene-1,2-diyl) dibenzene are described. The first is a three-step synthetic sequence from trimethyl(phenylethynyl)silane in 63% overall yield. The key transformations involved the stereospecific carb

Carbolithiation of diphenylacetylene as a stereoselective route to (Z)-tamoxifen and related tetrasubstituted olefins

(Chemical Equation Presented) Carbolithiation of diphenylacetylene can be exploited to generate (E)-1-lithio-1,2-diphenylalkyl-1-enes which can be reacted in situ with triisopropylborate to stereoselectively provide (E)-1,2-diphenyl-1-alkylene boronic acids. These tetrasubstituted vinylboronic acids served as versatile intermediates for the generation of tetrasubstituted olefins with retention of stereochemistry. The application of this method for the stereoselective synthesis of (Z)-tamoxifen and related analogues is described.

Highly Stereoselective Access to an (E)-Vinyl Bromide from an Aryl Ketone Leads to Short Syntheses of (Z)-Tamoxifen and Important Substituted Derivatives

The enol triflate derived from a 1-(4-alkoxyphenyl)-2-phenyl-1-butanone is unstable, fragmenting to a vinyl cation that can be trapped by bromide ion.The E isomer of the vinyl bromide which is formed in preference (20:1) gave, upon palladium-catalyzed cou

Stereospecific Synthesis of (Z)-Tamoxifen via Carbometalation of Alkynylsilanes

A sterospecific synthesis of (Z)-tamoxifen, a tetrasubstituted alkene with antiestrogenic activity, is described.The key reaction that establishes the olefin stereochemistry is a carbometalation of phenyl(trimethylsilyl)acetylene with diethylaluminum chloride-titanocene dichloride.A key intermediate that would lead to (E)-tamoxifen was also prepared in an analogous stereospecific manner.