97760-97-9

Basic information

• Product Name: 2-AMINO-5-IODOBENZOTRIFLUORIDE
• Synonyms: 4-IODO-2-(TRIFLUOROMETHYL)ANILINE;2-AMINO-5-IODOBENZOTRIFLUORIDE;ASISCHEM Z25859;2-Amino-5-iodobenzotrifluoride 98%;2-Amino-5-iodobenzotrifluoride98%;4-iodo-2-(trifluoromethyl)benzenamine;4-Iodo-2-trifluoromethylphenylamine;4-Iodo-2-(trifluoromethyl)aniline, 4-Iodo-alpha,alpha,alpha-trifluoro-o-toluidine
• CAS NO: 97760-97-9
• Molecular Formula: C₇H₅F₃IN
• Molecular Weight: 287.02
• Product Categories: Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 97760-97-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 262℃
• Flash Point: 112℃
• Appearance: /
• Density: 1.948
• Vapor Pressure: 0.0112mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-AMINO-5-IODOBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-IODOBENZOTRIFLUORIDE(97760-97-9)
• EPA Substance Registry System: 2-AMINO-5-IODOBENZOTRIFLUORIDE(97760-97-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 97760-97-9(Hazardous Substances Data)

Usage

Uses

4-Iodo-2-trifluoromethylaniline

InChI:InChI=1/C7H5F3IN/c8-7(9,10)5-3-4(11)1-2-6(5)12/h1-3H,12H2

Upstream product

• 887144-94-7 Togni's reagent II 
• 540-37-4 p-aminoiodobenzene 
• 796068-66-1 N-(4-iodo)phenylpicolinamide 
• 2314-97-8 iodotrifluoromethane 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 327-74-2 4-cyano-2-trifluoromethylaniline 
• 97804-09-6 diethyl 2-(4-amino-3-bromo-5-trifluoromethyl-benzoyl)-malonate 
• 97776-04-0 diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzoyl)-malonate 
• 97760-75-3 N-(4-acetyl-2-(trifluoromethyl)phenyl)acetamide 
• 175277-96-0 N-(4-cyano-2-(trifluoromethyl)phenyl)acetamide 
• 97776-05-1 4-amino-3-bromo-5-trifluoromethyl-benzoic acid 
• 95656-52-3 4-amino-3-chloro-5-(trifluoromethyl)benzoic acid 
• 63498-20-4 4-amino-3-bromo-5-trifluoromethyl-benzoyl chloride 
• 63498-15-7 4-amino-3-chloro-5-trifluoromethyl-benzoyl chloride 
• 400-76-0 4-amino-3-(trifluoromethyl)benzoic acid 
• 54295-65-7 1-(4'-Amino-3'-trifluoromethyl-phenyl)-2-tert-butylamino-ethanol 
• 772281-16-0 N-[4-(2-tert-Butylamino-1-hydroxy-ethyl)-2-trifluoromethyl-phenyl]-acetamide 
• 518342-93-3 trimethyl[4-(4-phenylethynyl-3-trifluoromethylphenylethynyl)-3-trifluoromethylphenylethynyl]silane 

Relevant articles and documents

Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent

A new transition-metal-free direct C–H trifluoromethylation reaction of (hetero)arenes with Togni's reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

Synthetic method of aminobenzotrifluoride and derivant thereof

The invention discloses a synthetic method of aminobenzotrifluoride and a derivant thereof. By adopting a method for performing amino-ortho-position trifluoromethylation on an amino-benzene compound,trifluoromethyl trimethylsilane is used a reaction reagent, free radical substitution reaction is carried out on an amino-ortho-position of the amino-benzene compound and then trifluoromethylation isdirectly carried out, so that a target product is obtained. The method disclosed by the invention has the advantages that raw materials are cheap and easy to obtain, the production is convenient, precious metal is not needed, environmental protection and safety are achieved, and purification is easy to carry out; the method can be developed into an industrial production method. Based on that, according to the synthetic method disclosed by the invention, screening and optimization on synthetic conditions of the compound are also carried out, so that the reaction yield is further improved.