Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Cefazolin sodium salt

Related Products

Hot Products

Name

Cefazolin sodium salt

EINECS 248-278-4
CAS No. 27164-46-1 Density N/A
PSA 237.76000 LogP -1.64200
Solubility 50 mg/mL in water Melting Point 190 °C
Formula C14H14N8O4S3. Na Boiling Point N/A
Molecular Weight 476.496 Flash Point N/A
Transport Information N/A Appearance White to off-white powder
Safety 22-36/37 Risk Codes 20/21/22-36/37/38-42/43
Molecular Structure Molecular Structure of 27164-46-1 (Cefazolin sodium salt) Hazard Symbols IrritantXi, HarmfulXn
Synonyms

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-,monosodium salt (8CI);3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid sodium salt;Acef;Ancef;Atirin;Biazolina;Bor-Cefazol;Cefacidal;Cefazil;Cefazoliin;Cefazolin sodium;Cefazoline sodium;Cephazolin sodium;Cephazolin sodiumsalt;Firmacef;Gramaxin;Kefzol;Lampocef;Liviclina;Monosodium cafazolin;Reflin;SKF 41558;Sodium cefazolin;Sodium cephazolin;Totacef;Zolicef;Cefazolin sodium salt;

Article Data 6

Cefazolin sodium salt Specification

1. Introduction of Cefazolin sodium salt
Cefazolin sodium salt is one kind of white or almost white powder. For being a kind of white to off-white powder, it is stable chemically but is incompatible with strong oxidizing agents. The IUPAC name of it is sodium 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. In addition, its product categories are including Active Pharmaceutical Ingredients; API; Antibiotics for Research and Experimental Use; beta-Lactams (Antibiotics for Research and Experimental Use); Biochemistry; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; A - KResearch Essentials. The Classification Code of it is Antibacterial [systemic]; Antibiotics; Drug / Therapeutic Agent; Human Data; Reproductive Effect.

2. Properties of Cefazolin sodium salt
Physical properties about Cefazolin sodium salt are:
(1)ACD/LogP: 1.13; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 12; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 226.14; (7)Exact Mass: 476.011958; (8)MonoIsotopic Mass: 476.011958.

3. Structure Descriptors of Cefazolin sodium salt
(1)Canonical SMILES: CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]
(2)InChI: InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1
(3)InChIKey: FLKYBGKDCCEQQM-UHFFFAOYSA-M 

4. Toxicity of Cefazolin sodium salt
Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 2200mg/kg (2200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
 
dog LD50 subcutaneous 4gm/kg (4000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Chemotherapy Vol. 18, Pg. 528, 1970.
human TDLo intramuscular 14mg/kg/D (14mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Japan Medical Gazette. Vol. 8(8), Pg. 10, 1971.
mouse LD50 intraperitoneal 6200mg/kg (6200mg/kg)   Drugs in Japan Vol. 6, Pg. 404, 1982.
mouse LD50 intravenous 3900mg/kg (3900mg/kg)   Journal of Infectious Diseases. Vol. 128, Pg. S379, 1973.
 
mouse LD50 oral > 11gm/kg (11000mg/kg)   Chemotherapy Vol. 18, Pg. 528, 1970.
mouse LD50 subcutaneous 7600mg/kg (7600mg/kg)   Journal of Infectious Diseases. Vol. 128, Pg. S379, 1973.
 
rabbit LD50 intravenous 2500mg/kg (2500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
 
rabbit LD50 subcutaneous > 6gm/kg (6000mg/kg)   Chemotherapy Vol. 18, Pg. 528, 1970.
rat LD50 intraperitoneal 7400mg/kg (7400mg/kg)   Drugs in Japan Vol. 6, Pg. 404, 1982.
rat LD50 intravenous 2760mg/kg (2760mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 35(Suppl,
rat LD50 oral > 11gm/kg (11000mg/kg)   Chemotherapy Vol. 18, Pg. 528, 1970.
rat LD50 subcutaneous 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Japan Medical Gazette. Vol. 8(8), Pg. 10, 1971.
women TDLo intravenous 660mg/kg/11D- (660mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nephron. Vol. 45, Pg. 72, 1987.
 

5. Safety information of Cefazolin sodium salt
For one thing, it is irritant to eyes, respiratory system and skin, which may also cause inflammation to the skin or other mucous membranes. For another thing, it is harmful which may cause damage to health. If by inhalation, in contact with skin and if swallowed, it will be very dangerous. Besides, this chemical may cause sensitisation by inhalation and skin contact. Therefore, you should wear suitable protective clothing and gloves. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and then remember not to breathe dust. 

6. Uses of Cefazolin sodium salt
As to its usage, it is usually used as the semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. It also used as an antibacterial. It is one kind of first-generation cephalosporins.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 27164-46-1