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| CAS No.: | 15686-71-2 |
|---|---|
| Name: | Cephalexin |
| Molecular Structure: | |
|
|
|
| Formula: | C16H17N3O4S |
| Molecular Weight: | 347.395 |
| Synonyms: | Sencephalin;Septilisin;Sialexin;Sinthecillin;Sporidex;Syncle;Tepaxin;Uphalexin;Vetolexin;Winlex;Alcephin;Biocef;Cefablan;Cefadina;Cefalexin;Cefaloto;Ceforal;Celexin;Cepexin; |
| EINECS: | 239-773-6 |
| Density: | 1.5 g/cm3 |
| Melting Point: | 196-198 °C |
| Boiling Point: | 727.4°C at760mmHg |
| Flash Point: | 393.7°C |
| Solubility: | NH4OH 1 M: 50 mg/mL, clear, yellow |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 42/43 |
| Safety: | 22-36/37-45 |
| PSA: | 138.03000 |
| LogP: | 1.47400 |
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Chemistry
Molecular Structure of Cephalexin (CAS NO.15686-71-2):
CAS Number: 15686-71-2
Molecular Formula: C16H17N3O4S
Molecular Weight: 347.39
EINECS: 239-773-6
Density: 1.5g/cm3
Melting Point: 196-198°C
Boiling Point: 727.4°C at760mmHg
Flash Point: 393.7°C
Appearance: white crystalline powder
Liansport Information: Hazard
Storage temp: 2-8°C
Solubility: NH4OH 1 M: 50 mg/mL
Merck: 13,1986
CAS DataBase Reference: 15686-71-2(CAS DataBase Reference)
InChI
InChI=1/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
Smiles
S1[C@@H]2[C@H](NC([C@@H](c3ccccc3)N)=O)C(=O)N2C(C(=O)O)=C(C1)C
Product Categories: Heterocyclic Compounds;Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals;A - KAntibiotics; Antibacterial; Antibiotics A to; Antibiotics A-FAntibiotics; Chemical Structure Class; Interferes with Cell Wall SynthesisAntibiotics; Mechanism of Action; Penicillins and Cephalosporins (beta-Lactams); Spectrum of Activity
Production
Cephalexin (CAS NO.15686-71-2) can produced in thie way:to penicillin potassium as raw material, by oxidation, expansion ring, cleavage was 7 - amino acid to the acyl oxy cephalosporin, and then condensation with the side chain derived.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969. |
| cat | LDLo | oral | 250mg/kg (250mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: NAUSEA OR VOMITING | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969. |
| dog | LD | oral | > 1gm/kg (1000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969. | |
| dog | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: FOOD INTAKE (ANIMAL) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968. |
| guinea pig | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969. |
| guinea pig | LDLo | oral | 5gm/kg (5000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969. |
| human | TDLo | oral | 14mg/kg/D (14mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 361, 1968. |
| monkey | LDLo | oral | > 1gm/kg (1000mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968. | |
| mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968. |
| mouse | LD50 | oral | 1495mg/kg (1495mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 27(Suppl, |
| mouse | LD50 | subcutaneous | 1150mg/kg (1150mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 227, 1969. |
| rabbit | LDLo | intraperitoneal | > 4gm/kg (4000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968. |
| rabbit | LDLo | oral | 2500mg/kg (2500mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969. |
| rat | LD50 | intraperitoneal | 4gm/kg (4000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 390, 1969. |
| rat | LD50 | oral | > 20gm/kg (20000mg/kg) | BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 27(Suppl, |
| rat | LD50 | subcutaneous | 6100mg/kg (6100mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 390, 1969. |
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion: nausea, vomiting, and diarrhea. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Safety Information of Cephalexin (CAS NO.15686-71-2).
Hazard Codes: 
Xn
Safety Statements: 22-36/37-45
S22: Do not breathe dust.
S36/37:Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Risk Codes: R42/43
R42/43: May cause sensitization by inhalation and skin contact.
WGK Germany: 3
RTECS: XI0350000
Specification
Cephalexin , with CAS number of 15686-71-2, can be called (6r-(6alpha,7beta(r*)))-ino)-3-methyl-8-oxo ; 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((aminophenylacetyl)am;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(2-amino-2-phenylaceta ; 7-(d-2-amino-2-phenylacetamido)-3-methyl-delta(sup3)-cephem-4-carboxylica ; 7-(d-2-amino-2-phenylacetamido)-3-methyl-delta3-cephem-4-carboxylicacid ; 7-(d-alpha-aminophenylacetamido)desacetoxycephalosporanicacid ; 7-beta-(d-alpha-amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxyli . It is a white crystalline powder.The usage of Cephalexin (CAS NO.15686-71-2) is semi-synthetic cephalosporin antibiotic.