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Chlorquinaldol

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Name

Chlorquinaldol

EINECS 200-789-3
CAS No. 72-80-0 Density 1.467 g/cm3
PSA 33.12000 LogP 3.55560
Solubility insoluble in water Melting Point 108-112 °C (dec.)(lit.)
Formula C10H7Cl2NO Boiling Point 350.7 °C at 760 mmHg
Molecular Weight 228.078 Flash Point 165.9 °C
Transport Information UN 2811 6.1/PG 3 Appearance yellowish to beige-brown powder
Safety 26-36-36/37/39-45 Risk Codes 22-36/37/38-23/24/25
Molecular Structure Molecular Structure of 72-80-0 (5,7-Dichloro-8-hydroxyquinaldine) Hazard Symbols HarmfulXn,ToxicT
Synonyms

5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-Dichloro-2-methyl-8-quinolinol;5,7-Dichloro-2-styrylquinoline;5,7-Dichloro-8-hydroxy-2-methylquinoline;5,7-Dichloro-8-hydroxyquinaldine;5,7-Dichloro-8-quinaldinol;Chloquinan;Chlorchinaldin;Chlorguinaldon;Florabina;Gyno-Sterosan;Gynotherax;Hydroxydichloroquinaldinol;Intensol;Quesil;Saprosan;Siogen;Siogenal;Siogene;Siogeno;Siogenon;Siosept;Siosteran;Sterosan;Steroxin;Sterozan;Vagisteran;

Article Data 17

Chlorquinaldol Synthetic route

826-81-3

2-methyl-8-quinolinol

72-80-0

chloroquinaldol

Conditions
ConditionsYield
With aluminum (III) chloride; N-chloro-succinimide In dichloromethane at 35℃; for 8h; Temperature; Solvent; Darkness; Green chemistry;98.8%
With hydrogenchloride; chlorine In water Reagent/catalyst; Inert atmosphere; Darkness;98.9%
With hydrogenchloride; sodium hypochlorite In water at 20 - 30℃; for 4.5h; Temperature;97.7%
21168-33-2

5,7-dichloro-8-hydroxyquinoline 1-oxide

676-58-4

methylmagnesium chloride

72-80-0

chloroquinaldol

Conditions
ConditionsYield
With copper(l) chloride; magnesium chloride In diethyl ether at 23℃; for 12h; Grignard Reaction; Inert atmosphere;63%
826-81-3

2-methyl-8-quinolinol

4369-36-2

dichlorohydantoin

72-80-0

chloroquinaldol

Conditions
ConditionsYield
With acetic acid for 3h; Cooling with ice;
72-80-0

chloroquinaldol

24010-07-9

5,7-dichloro-8-hydroxy-2-quinolinecarboxaldehyde

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane at 50 - 80℃; for 3h;100%
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;80%
With selenium(IV) oxide In 1,4-dioxane at 55 - 80℃;2.1 g
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;
72-80-0

chloroquinaldol

5,7-dichloro-2-methyl-quinoline-8-oxysulfonyl fluoride

Conditions
ConditionsYield
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h;
Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h;
97%
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h;
Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h; Inert atmosphere;
97%
72-80-0

chloroquinaldol

4923-85-7

tert-butylphenylphosphinic acid chloride

1227180-25-7

5,7-dichloro-2-methylquinolin-8-yl tert-butyl(phenyl)posphinate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 24h; Reflux; Inert atmosphere;96%

{Ir(mppy)2Cl}2

72-80-0

chloroquinaldol

C34H26Cl2IrN3O

Conditions
ConditionsYield
In ethanol; acetone at 85℃; for 5h; Solvent; Temperature;95.3%

diiodo(p-cymene)ruthenium(II) dimer

72-80-0

chloroquinaldol

[(η6-p-cymene)Ru(2-methyl-5,7-dichloro-8-hydroxyquinolinato)I]

Conditions
ConditionsYield
In methanol; dichloromethane at 65℃; for 6h; Reflux;95.2%
72-80-0

chloroquinaldol

C12H12Cl3NO2PtS

Conditions
ConditionsYield
In methanol; dimethyl sulfoxide at 80℃; for 12h; Solvent; Temperature;95%
72-80-0

chloroquinaldol

74-88-4

methyl iodide

1053246-24-4

5,7-dichloro-8-methoxy-2-methylquinoline

Conditions
ConditionsYield
Stage #1: chloroquinaldol With potassium tert-butylate In tetrahydrofuran for 3h; Reflux; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;
94%
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 40℃; for 30h;83%

Chlorquinaldol Chemical Properties

The molecular formula of CHLOROQUINALDOL(72-80-0)  is C10H7Cl2NO and its formula weight is 228.07.
The density of CHLOROQUINALDOL(72-80-0)  is  and it has a melting point of  108-112 °C (dec.)(lit.).
The chemical synonyms of  CHLOROQUINALDOL(72-80-0) are 5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-dichloro-2-methyl-8-quinolino;8-Quinolinol, 5,7-dichloro-2-methyl-;Afungil;Chloquinan;Chlorchinaldin;Chlorchinaldol;Chlorguinaldon
The molecular structure of CHLOROQUINALDOL(72-80-0) :

Chlorquinaldol Toxicity Data With Reference

1.   

orl-rat LD50:660 mg/kg

   29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.
2.   

orl-dog LD50:2250 mg/kg

   29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.
3.   

orl-rbt LD50:160 mg/kg

   29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.

Chlorquinaldol Safety Profile

Poison by ingestion. When heated to decomposition it emits very toxic fumes of Cl and NOx.
Hazard Codes  Xn,T
Risk Statements  22-36/37/38-23/24/25
Safety Statements  26-36-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  VC5600000
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