CAS No.72-80-0,5,7-Dichloro-8-hydroxyquinaldine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	72-80-0
Name:	5,7-Dichloro-8-hydroxyquinaldine
Article Data:	17

Formula:	C₁₀H₇Cl₂NO
Molecular Weight:	228.078
Synonyms:	5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-Dichloro-2-methyl-8-quinolinol;5,7-Dichloro-2-styrylquinoline;5,7-Dichloro-8-hydroxy-2-methylquinoline;5,7-Dichloro-8-hydroxyquinaldine;5,7-Dichloro-8-quinaldinol;Chloquinan;Chlorchinaldin;Chlorguinaldon;Florabina;Gyno-Sterosan;Gynotherax;Hydroxydichloroquinaldinol;Intensol;Quesil;Saprosan;Siogen;Siogenal;Siogene;Siogeno;Siogenon;Siosept;Siosteran;Sterosan;Steroxin;Sterozan;Vagisteran;
EINECS:	200-789-3
Density:	1.467 g/cm³
Melting Point:	108-112 °C (dec.)(lit.)
Boiling Point:	350.7 °C at 760 mmHg
Flash Point:	165.9 °C
Solubility:	insoluble in water
Appearance:	yellowish to beige-brown powder
Hazard Symbols:	Xn,T
Risk Codes:	22-36/37/38-23/24/25
Safety:	26-36-36/37/39-45
Transport Information:	UN 2811 6.1/PG 3
PSA:	33.12000
LogP:	3.55560

Synthetic route

: 826-81-3
2-methyl-8-quinolinol

: 72-80-0
chloroquinaldol

Conditions

Conditions	Yield
With aluminum (III) chloride; N-chloro-succinimide In dichloromethane at 35℃; for 8h; Temperature; Solvent; Darkness; Green chemistry;	98.8%
With hydrogenchloride; chlorine In water Reagent/catalyst; Inert atmosphere; Darkness;	98.9%
With hydrogenchloride; sodium hypochlorite In water at 20 - 30℃; for 4.5h; Temperature;	97.7%

: 21168-33-2
5,7-dichloro-8-hydroxyquinoline 1-oxide

: 676-58-4
methylmagnesium chloride

: 72-80-0
chloroquinaldol

Conditions

Conditions	Yield
With copper(l) chloride; magnesium chloride In diethyl ether at 23℃; for 12h; Grignard Reaction; Inert atmosphere;	63%

: 826-81-3
2-methyl-8-quinolinol

: 4369-36-2
dichlorohydantoin

: 72-80-0
chloroquinaldol

Conditions

Conditions	Yield
With acetic acid for 3h; Cooling with ice;

: 72-80-0
chloroquinaldol

: 24010-07-9
5,7-dichloro-8-hydroxy-2-quinolinecarboxaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane at 50 - 80℃; for 3h;	100%
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;	80%
With selenium(IV) oxide In 1,4-dioxane at 55 - 80℃;	2.1 g
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;

: 72-80-0
chloroquinaldol

: 5,7-dichloro-2-methyl-quinoline-8-oxysulfonyl fluoride

Conditions

Conditions	Yield
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h;	97%
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h; Inert atmosphere;	97%

: 72-80-0
chloroquinaldol

: 4923-85-7
tert-butylphenylphosphinic acid chloride

: 1227180-25-7
5,7-dichloro-2-methylquinolin-8-yl tert-butyl(phenyl)posphinate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 24h; Reflux; Inert atmosphere;	96%

: {Ir(mppy)2Cl}2

: 72-80-0
chloroquinaldol

: C34H26Cl2IrN3O

Conditions

Conditions	Yield
In ethanol; acetone at 85℃; for 5h; Solvent; Temperature;	95.3%

: diiodo(p-cymene)ruthenium(II) dimer

: 72-80-0
chloroquinaldol

: [(η6-p-cymene)Ru(2-methyl-5,7-dichloro-8-hydroxyquinolinato)I]

Conditions

Conditions	Yield
In methanol; dichloromethane at 65℃; for 6h; Reflux;	95.2%

: 72-80-0
chloroquinaldol

: 75992-73-3, 25794-47-2, 30729-25-0, 15274-33-6, 22840-91-1, 14568-13-9
cis-dichlorobis(dimethylsulfoxide)platinum(II)

: C12H12Cl3NO2PtS

Conditions

Conditions	Yield
In methanol; dimethyl sulfoxide at 80℃; for 12h; Solvent; Temperature;	95%

: 72-80-0
chloroquinaldol

: 74-88-4
methyl iodide

: 1053246-24-4
5,7-dichloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Stage #1: chloroquinaldol With potassium tert-butylate In tetrahydrofuran for 3h; Reflux; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;	94%
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 40℃; for 30h;	83%

Raw Materials

676-58-4

826-81-3

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Chemistry

The molecular formula of CHLOROQUINALDOL(72-80-0) is C₁₀H₇Cl₂NO and its formula weight is 228.07.
The density of CHLOROQUINALDOL(72-80-0) is and it has a melting point of 108-112 °C (dec.)(lit.).
The chemical synonyms of CHLOROQUINALDOL(72-80-0) are 5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-dichloro-2-methyl-8-quinolino;8-Quinolinol, 5,7-dichloro-2-methyl-;Afungil;Chloquinan;Chlorchinaldin;Chlorchinaldol;Chlorguinaldon
The molecular structure of CHLOROQUINALDOL(72-80-0) :

Toxicity Data With Reference

1.	orl-rat LD50:660 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.
2.	orl-dog LD50:2250 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.
3.	orl-rbt LD50:160 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.

Safety Profile

Poison by ingestion. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.
Hazard Codes Xn,T
Risk Statements 22-36/37/38-23/24/25
Safety Statements 26-36-36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS VC5600000