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| CAS No.: | 132203-70-4 |
|---|---|
| Name: | Cilnidipine |
| Molecular Structure: | |
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| Formula: | C27H28N2O7 |
| Molecular Weight: | 492.529 |
| Synonyms: | Cinalong;2-methoxyethyl cinnamyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Atelec;Cilnidipine (JAN);3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-;Clinidipine (+-)-;(+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Siscard;Atelec (TN);FRC 8653;Choriogonadotropin [alpha-subunit]; |
| EINECS: | 634-350-6 |
| Density: | 1.24 g/cm3 |
| Melting Point: | 97-99 °C |
| Boiling Point: | 652.6 °C at 760 mmHg |
| Flash Point: | 348.5 °C |
| Appearance: | yellow crystalline solid |
| Hazard Symbols: | Xi |
| Risk Codes: | 41 |
| Safety: | 26-39 |
| PSA: | 119.68000 |
| LogP: | 5.12780 |
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(E/Z)-2-methoxyethyl 2-(3-nitrobenzylidene)-acetoacetate
- 132203-70-4
cilnidipine
| Conditions | Yield |
|---|---|
| Stage #1: 3-amino-2-butenoic acid cinnamyl ester; (E/Z)-2-methoxyethyl 2-(3-nitrobenzylidene)-acetoacetate In ethanol for 1h; Reflux; Stage #2: With hydrogenchloride In ethanol; water for 1h; Solvent; Reagent/catalyst; Reflux; | 91.5% |
| In ethanol for 22h; Reflux; Large scale; |
| Conditions | Yield |
|---|---|
| In ethanol at 50℃; Solvent; Temperature; | 91.4% |
- 132203-70-4
cilnidipine
| Conditions | Yield |
|---|---|
| With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 2h; | 89% |
| With 1,10-Phenanthroline; cerium(IV) sulphate; sulfuric acid In acetic acid |
- 132203-70-4
cilnidipine
| Conditions | Yield |
|---|---|
| With iron; acetic acid at 100℃; for 0.25h; | 78% |
- 128446-35-5
heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
- 132203-70-4
cilnidipine
| Conditions | Yield |
|---|---|
| In water at 20℃; for 24h; |
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Chemistry
Molecular Structure of Cilnidipine (CAS NO.132203-70-4):
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Molecular Formula: C27H28N2O7
Molecular Weight: 492.5204
IUPAC Name: 3-O-(2-Methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms of Cilnidipine (CAS NO.132203-70-4): Cilnidipine [INN] ; Atelec ; Cinalong ; FRC 8653 ; Siscard ; (+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate ; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-
CAS NO: 132203-70-4
Classification Code: Calcium channel blockers ; Cardiovascular Agents ; Drug / Therapeutic Agent ; Membrane Transport Modulators ; Reproductive Effect
Melting Point: 97-99°C
Index of Refraction: 1.592
Molar Refractivity: 134.37 cm3
Molar Volume: 397 cm3
Surface Tension: 49.2 dyne/cm
Density: 1.24 g/cm3
Flash Point: 348.5 °C
Enthalpy of Vaporization: 96.14 kJ/mol
Boiling Point: 652.6 °C at 760 mmHg
Vapour Pressure: 6.57E-17 mmHg at 25°C
Uses
Cilnidipine (CAS NO.132203-70-4) can be used as a dihydropyridine CALCIUM channel blocker
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 2gm/kg (2000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, | |
| mouse | LD50 | intraperitoneal | 1845mg/kg (1845mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, | |
| mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, | |
| rat | LD50 | intraperitoneal | 426mg/kg (426mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, |
| rat | LD50 | oral | 4412mg/kg (4412mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl, |