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Cilnidipine
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Name

Cilnidipine

 EINECS 634-350-6
CAS No. 132203-70-4 Density 1.24 g/cm3
PSA 119.68000 LogP 5.12780
Solubility N/A Melting Point 97-99 °C
Formula C27H28N2O7 Boiling Point 652.6 °C at 760 mmHg
Molecular Weight 492.529 Flash Point 348.5 °C
Transport Information N/A Appearance yellow crystalline solid
Safety 26-39 Risk Codes 41
Molecular Structure Molecular Structure of 132203-70-4 (Cilnidipine) Hazard Symbols Xi
Synonyms

Cinalong;2-methoxyethyl cinnamyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Atelec;Cilnidipine (JAN);3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-;Clinidipine (+-)-;(+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Siscard;Atelec (TN);FRC 8653;Choriogonadotropin [alpha-subunit];

Article Data 4

Cilnidipine Synthetic route

3-amino-2-butenoic acid cinnamyl ester

39562-22-6

(E/Z)-2-methoxyethyl 2-(3-nitrobenzylidene)-acetoacetate

132203-70-4

cilnidipine

Conditions
ConditionsYield
Stage #1: 3-amino-2-butenoic acid cinnamyl ester; (E/Z)-2-methoxyethyl 2-(3-nitrobenzylidene)-acetoacetate In ethanol for 1h; Reflux;
Stage #2: With hydrogenchloride In ethanol; water for 1h; Solvent; Reagent/catalyst; Reflux;		91.5%
In ethanol for 22h; Reflux; Large scale;

3-amino-2-butenoic acid cinnamyl ester

C14H17NO6

132203-70-4

cilnidipine

Conditions
ConditionsYield
In ethanol at 50℃; Solvent; Temperature;91.4%
132203-70-4

cilnidipine

3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 2h;89%
With 1,10-Phenanthroline; cerium(IV) sulphate; sulfuric acid In acetic acid
132203-70-4

cilnidipine

3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] 4-(3-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With iron; acetic acid at 100℃; for 0.25h;78%
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

132203-70-4

cilnidipine

C105H196O56*C27H28N2O7

Conditions
ConditionsYield
In water at 20℃; for 24h;

Cilnidipine Chemical Properties

Molecular Structure of Cilnidipine (CAS NO.132203-70-4):

Molecular Formula: C27H28N2O7
Molecular Weight: 492.5204
IUPAC Name: 3-O-(2-Methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms of Cilnidipine (CAS NO.132203-70-4): Cilnidipine [INN] ; Atelec ; Cinalong ; FRC 8653 ; Siscard ; (+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate ; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-
CAS NO: 132203-70-4
Classification Code: Calcium channel blockers ; Cardiovascular Agents ; Drug / Therapeutic Agent ; Membrane Transport Modulators ; Reproductive Effect
Melting Point: 97-99°C
Index of Refraction: 1.592
Molar Refractivity: 134.37 cm3
Molar Volume: 397 cm3
Surface Tension: 49.2 dyne/cm
Density: 1.24 g/cm3
Flash Point: 348.5 °C
Enthalpy of Vaporization: 96.14 kJ/mol
Boiling Point: 652.6 °C at 760 mmHg
Vapour Pressure: 6.57E-17 mmHg at 25°C

Cilnidipine Uses

 Cilnidipine (CAS NO.132203-70-4) can be used as a dihydropyridine CALCIUM channel blocker

Cilnidipine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 intraperitoneal 1845mg/kg (1845mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 oral > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 intraperitoneal 426mg/kg (426mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 oral 4412mg/kg (4412mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,

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