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Closantel
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Name

Closantel

 EINECS 260-967-1
CAS No. 57808-65-8 Density 1.943 g/cm3
PSA 73.12000 LogP 7.19738
Solubility N/A Melting Point 210 - 22oC
Formula C22H14Cl2I2N2O2 Boiling Point 590.5 °C at 760 mmHg
Molecular Weight 663.08 Flash Point 310.9 °C
Transport Information UN 2811 Appearance white to yellowish powder
Safety Risk Codes 22
Molecular Structure Molecular Structure of 57808-65-8 (Closantel) Hazard Symbols HarmfulXn
Synonyms

NSC 335306;Zycloz;

Article Data 2

Closantel Synthetic route

61437-85-2

2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile

2-hydroxy-3,5-diiodobenzoyl derivative

2-hydroxy-3,5-diiodobenzoyl derivative

57808-65-8

closantel

Conditions
ConditionsYield
In toluene at 50℃; for 6h; Solvent; Reflux; Sealed tube;89.1%
123-91-1

1,4-dioxane

42016-91-1

2-hydroxy-3,5-diiodobenzoyl chloride

61437-85-2

2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile

57808-65-8

closantel

140-53-4

p-chlorobenzyl cyanide

57808-65-8

closantel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate; methanol / 3 h / 50 °C / Sealed tube
2: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube
3: toluene / 6 h / 50 °C / Reflux; Sealed tube
View Scheme
89-59-8

4-chloro-2-nitrotoluene

57808-65-8

closantel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate; methanol / 3 h / 50 °C / Sealed tube
2: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube
3: toluene / 6 h / 50 °C / Reflux; Sealed tube
View Scheme
844-24-6

4-chloro-α-(2-chloro-4-hydroxyimino-5-methyl-2,5-cyclohexadien-1-ylidene)phenylacetonitrile

57808-65-8

closantel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube
2: toluene / 6 h / 50 °C / Reflux; Sealed tube
View Scheme
57808-65-8

closantel

closantel sodium salt

Conditions
ConditionsYield
With sodium hydroxide In water at 70℃; for 6h; Sealed tube;99.3%
78-96-6, 1674-56-2

3-amino-2-propanol

57808-65-8

closantel

isopropanolamine closantel salt

Conditions
ConditionsYield
In tetrahydrofuran; acetonitrile
6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

57808-65-8

closantel

N-methylglucamine salt of closantel

Conditions
ConditionsYield
In propylene glycol; ethanol; benzyl alcohol
111-42-2

2,2'-iminobis[ethanol]

57808-65-8

closantel

diethanolamine closantel salt

Conditions
ConditionsYield
In propylene glycol; ethanol; benzyl alcohol
141-43-5

ethanolamine

57808-65-8

closantel

closantel ethanolamine salt

Conditions
ConditionsYield
In ethoxyethoxyethanol
In 2-pyrrolidinon; polypropylene glycol 400; benzyl alcohol

Closantel Chemical Properties

The Molecular formula of  N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（57808-65-8）：C22H14Cl2I2N2O2 
The Molecular Weight of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（ 57808-65-8）：663.07
The Molecular Structure of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（ 57808-65-8）is :
Density:1.943 g/cm3
melting point:210 - 220°C
Boiling point: 590.5 °C at 760 mmHg
Flash point: 310.9 °C
Solubility in water:Insoluble
Index of Refraction: 1.736
Molar Refractivity: 137 cm3
Polarizability:  54.31 10-24cm3
Surface Tension: 68.2 dyne/cm
Enthalpy of Vaporization:  91.36 kJ/mol
Vapour Pressure:1.53E-14 mmHg at 25°C
Appearance:Off white crystalline powder
IUPAC Name: N-[5-chloro-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-2-hydroxy-3,5-diiodo-benzamide
Synonyms:5-diiodo-y-;benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox;faskoverm;iodobenzamide;5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE;CLOSANTEL;CLOSANTEL BASE;n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di

Closantel Toxicity Data With Reference

1.   

orl-rat LD50:262 mg/kg

   DCTODJ    Drug and Chemical Toxicology. 8 (1985),101.
2.   

ims-rat LD50:28,400 µg/kg

   DCTODJ    Drug and Chemical Toxicology. 8 (1985),101.
3.   

orl-mus LD50:331 mg/kg

   DCTODJ    Drug and Chemical Toxicology. 8 (1985),101.
4.   

ims-mus LD50:56,800 µg/kg

   DCTODJ    Drug and Chemical Toxicology. 8 (1985),101.

Closantel Safety Profile

Poison by ingestion and intramuscular routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, I−, and Cl−.
Hazard Codes:Xn
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
RIDADR :2811
RTECS:CV2444250
HazardClass:6.1(b)
PackingGroup:III

Closantel Specification

Stable under ordinary conditions
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