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| CAS No.: | 57808-65-8 |
|---|---|
| Name: | Closantel |
| Molecular Structure: | |
|
|
|
| Formula: | C22H14Cl2I2N2O2 |
| Molecular Weight: | 663.08 |
| Synonyms: | NSC 335306;Zycloz; |
| EINECS: | 260-967-1 |
| Density: | 1.943 g/cm3 |
| Melting Point: | 210 - 22oC |
| Boiling Point: | 590.5 °C at 760 mmHg |
| Flash Point: | 310.9 °C |
| Appearance: | white to yellowish powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Transport Information: | UN 2811 |
| PSA: | 73.12000 |
| LogP: | 7.19738 |
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2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile
- 57808-65-8
closantel
| Conditions | Yield |
|---|---|
| In toluene at 50℃; for 6h; Solvent; Reflux; Sealed tube; | 89.1% |
- 123-91-1
1,4-dioxane
- 42016-91-1
2-hydroxy-3,5-diiodobenzoyl chloride
- 61437-85-2
2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile
- 57808-65-8
closantel
- 140-53-4
p-chlorobenzyl cyanide
- 57808-65-8
closantel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: sodium methylate; methanol / 3 h / 50 °C / Sealed tube 2: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube 3: toluene / 6 h / 50 °C / Reflux; Sealed tube View Scheme |
- 89-59-8
4-chloro-2-nitrotoluene
- 57808-65-8
closantel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: sodium methylate; methanol / 3 h / 50 °C / Sealed tube 2: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube 3: toluene / 6 h / 50 °C / Reflux; Sealed tube View Scheme |
- 844-24-6
4-chloro-α-(2-chloro-4-hydroxyimino-5-methyl-2,5-cyclohexadien-1-ylidene)phenylacetonitrile
- 57808-65-8
closantel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hydrazine hydrate; sodium hydroxide / diethylene glycol / 6 h / 200 °C / Sealed tube 2: toluene / 6 h / 50 °C / Reflux; Sealed tube View Scheme |
- 57808-65-8
closantel
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water at 70℃; for 6h; Sealed tube; | 99.3% |
| Conditions | Yield |
|---|---|
| In tetrahydrofuran; acetonitrile |
| Conditions | Yield |
|---|---|
| In propylene glycol; ethanol; benzyl alcohol |
| Conditions | Yield |
|---|---|
| In propylene glycol; ethanol; benzyl alcohol |
| Conditions | Yield |
|---|---|
| In ethoxyethoxyethanol | |
| In 2-pyrrolidinon; polypropylene glycol 400; benzyl alcohol |
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Chemistry
The Molecular formula of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（57808-65-8）：C22H14Cl2I2N2O2
The Molecular Weight of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（ 57808-65-8）：663.07
The Molecular Structure of N-(5-CHLORO-4-((4-CHLOROPHENYL) CYANOMETHYL)-2-METHYLPHENYL)-2-HYDROXY-3, 5-DIIODOBENZAMIDE（ 57808-65-8）is :
Density:1.943 g/cm3
melting point:210 - 220°C
Boiling point: 590.5 °C at 760 mmHg
Flash point: 310.9 °C
Solubility in water:Insoluble
Index of Refraction: 1.736
Molar Refractivity: 137 cm3
Polarizability: 54.31 10-24cm3
Surface Tension: 68.2 dyne/cm
Enthalpy of Vaporization: 91.36 kJ/mol
Vapour Pressure:1.53E-14 mmHg at 25°C
Appearance:Off white crystalline powder
IUPAC Name: N-[5-chloro-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-2-hydroxy-3,5-diiodo-benzamide
Synonyms:5-diiodo-y-;benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox;faskoverm;iodobenzamide;5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE;CLOSANTEL;CLOSANTEL BASE;n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di
Toxicity Data With Reference
| 1. | orl-rat LD50:262 mg/kg | DCTODJ Drug and Chemical Toxicology. 8 (1985),101. | ||
| 2. | ims-rat LD50:28,400 µg/kg | DCTODJ Drug and Chemical Toxicology. 8 (1985),101. | ||
| 3. | orl-mus LD50:331 mg/kg | DCTODJ Drug and Chemical Toxicology. 8 (1985),101. | ||
| 4. | ims-mus LD50:56,800 µg/kg | DCTODJ Drug and Chemical Toxicology. 8 (1985),101. |
Safety Profile
Poison by ingestion and intramuscular routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, I−, and Cl−.
Hazard Codes:Xn
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
RIDADR :2811
RTECS:CV2444250
HazardClass:6.1(b)
PackingGroup:III