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| CAS No.: | 1264-72-8 |
|---|---|
| Name: | Colistin sulfate |
| Molecular Structure: | |
|
|
|
| Formula: | 2(C52H98N16O13).5(H2SO4) |
| Molecular Weight: | 1253.51000 |
| Synonyms: | NSC 248648;N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;Belcomycin;Polymyxin E sulfate;Colomycin; Colomycin syrup; |
| EINECS: | 215-034-3 |
| Density: | == |
| Melting Point: | 200-220 °C |
| Boiling Point: | 1537.3 °C at 760 mmHg |
| Flash Point: | 883.5 °C |
| Solubility: | Soluble in water |
| Appearance: | Powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 25 |
| Safety: | 45 |
| PSA: | 573.64000 |
| LogP: | 1.96320 |
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Standards and Recommendations
Enterprise Standard:
Content≥98.0%
Specification
The Colistin sulfate, with the CAS registry number 408332-79-6, is also known as Belcomycin. It belongs to the product categories of Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Veterinaries. Its EINECS number is 215-034-3. What's more, its systematic name is N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate. Its classification code is Antibacterial. It is a cyclic polypeptide antibiotic from Bacillus colistinus. Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora. Colistin sulfate is also used as topical creams, powders, and otic solutions. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides. It should be ensured that the workshop is well ventilated or equipped with exhaust devices.
When you are using this chemical, please be cautious about it as the following:
This chemical is toxic if swallowed. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
(2)Smiles: N1[C@H](C(NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C1=O)CCN)=O)CCN)CC(C)C)CC(C)C)CCN)NC([C@@H](NC(=O)[C@H]([C@H](O)C)NC([C@@H](NC(=O)CCCC[C@@H](CC)C)CCN)=O)CCN)=O)=O)[C@H](O)C.S(O)(O)(=O)=O
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | subcutaneous | 58mg/kg (58mg/kg) | Chemotherapy Vol. 16, Pg. 105, 1968. | |
| mouse | LD50 | intraperitoneal | 21800ug/kg (21.8mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961. | |
| mouse | LD50 | intravenous | 6mg/kg (6mg/kg) | Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960. | |
| mouse | LD50 | oral | 793mg/kg (793mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961. | |
| mouse | LD50 | subcutaneous | 53500ug/kg (53.5mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961. | |
| rat | LD50 | intraperitoneal | 10572ug/kg (10.572mg/kg) | Antibiotics Annual. Vol. 7, Pg. 61, 1959/1960. | |
| rat | LD50 | oral | 121mg/kg (121mg/kg) | Antibiotics Annual. Vol. 7, Pg. 61, 1959/1960. | |
| rat | LD50 | subcutaneous | 72200ug/kg (72.2mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 7, 1979. |